Aktiviteter pr. år
Projektdetaljer
Beskrivelse
Infection is the most common cause of death in early life, especially for newborns and can be reduced by immunization but insufficient knowledge of how vaccines protect the very young limits their optimal use. To gain insight into how vaccines induce protection of the most vulnerable, this National Institutes of Health (NIH)/National Institute of Allergy & Infectious Diseases (NIAID)-funded Human Immunology Project Consortium (HIPC) study, based at Boston Children's Hospital and conducted by the Expanded Program on Immunization Consortium (EPIC), employs two novel approaches studying newborn responses to hepatitis B vaccine (HBV): (a) systems biology that uses technologies which comprehensively measure global changes in molecules such as transcriptomics (RNA) and proteomics (proteins), as well as cell composition of the blood and (b) use of human newborn blood components, collected prior to immunization, to model vaccine responses in vitro (outside the body). Characterizing vaccine-induced molecular patterns ("signatures") that correspond to vaccine-mediated protection will accelerate development and optimization of vaccines against early life infections of major global health importance
(https://clinicaltrials.gov/ct2/show/NCT03246230).
(https://clinicaltrials.gov/ct2/show/NCT03246230).
Lægmandssprog
Improve our understanding of our immune system and vaccinations, with a focus on the developing immune system in newborns.
Akronym | EPIC-HIPC |
---|---|
Status | Igangværende |
Effektiv start/slut dato | 01/01/2016 → 01/12/2026 |
Samarbejdspartnere
- Boston Children's Hospital
Finansiering
- Lundbeckfonden: 18.580,00 kr.
Fingerprint
Udforsk forskningsemnerne, som dette projekt berører. Disse etiketter er oprettet på grundlag af de underliggende bevillinger/legater. Sammen danner de et unikt fingerprint.
Aktiviteter
-
EPIC-HIPC manuscript committee (Ekstern organisation)
Bennike, T. B. (Forperson)
1 apr. 2020 → …Aktivitet: Medlemskab › Medlemskab af udvalg, kommission, råd, nævn, forening, organisation eller lignende
-
Preparing for life: Plasma proteome changes and immune system development during the first week of human life
Bennike, T. B. (Foredragsholder)
3 dec. 2019Aktivitet: Foredrag og mundtlige bidrag › Konferenceoplæg
-
Ontogeny of the plasma proteome across the first week of human life
Bennike, T. B. (Foredragsholder)
18 okt. 2019Aktivitet: Foredrag og mundtlige bidrag › Konferenceoplæg
Publikation
- 1 Poster
-
Ontogeny of the plasma proteome during the first week of life
Bennike, T. B., Fatou, B., Wurie, Z., Idoko, O. T., Kampmann, B., Levy, O. & Steen, H., 27 mar. 2019.Publikation: Konferencebidrag uden forlag/tidsskrift › Poster › Forskning › peer review
Presse/medier
-
How Do Our Immune Systems Develop in the First Days of Life?
22/10/2020
6 elementer af Mediedækning
Presse/medie
-