PCB in serum and hand wipes from exposed residents living in contaminated high-rise apartment buildings and a reference group

Exposure to polychlorinated biphenyls (PCB) in buildings constructed with PCB-containing materials can lead toincreased body burden of PCB for building users. Exposure to PCB from building related sources was assessed bymeasuring PCB in serum and hand wipes in two groups of tenants living in the same building estate in apart-ments constructed with and without PCB. The median serum levels of the sum of 19 PCB congeners was 777 ng/glw (5–95th percentile: 219–2576 ng/g lw) for the exposed group and 282 ng/g lw (5–95th percentile:49.8–797 ng/g lw) for the reference group. The congener pattern in serum of the exposed was shifted towardslower chlorinated congeners and was dominated by tri- and tetrachlorinated congeners. The largest difference inserum levels between the groups was observed for PCB-28, with median levels of the exposed being 70 timeshigher than in the reference group. For very persistent lower chlorinated congeners, like PCB-28, 66 and 74, anincrease with residence times was observed as a result of accumulation over time. Less persistent congeners suchas PCB-44 and 70 were also elevated in the exposed group -but independent of residence time. The less persistentcongeners can therefore be used as markers of recent exposure to original PCB sources. The hand wipes alsoshowed a large exposure contrast, e.g. PCB-28 being more than 60 times higher in the exposed group comparedto the reference group (medians 14.4 and 0.23 ng/wipe, respectively) and no overlap between the groups. Allmeasured di- to pentaPCB congeners were significantly higher in hand wipes from the exposed group comparedwith the reference group. Thus hand wipes seem to be a good, non-invasive screening tool for ongoing indoorexposure to PCB. Furthermore, the measured level of PCB on hand wipes was significantly correlated to PCB inblood for almost all congeners. In conclusion, PCB exposure in contaminated buildings can contribute sig-nificantly to the exposure and total body burden of PCB and the lower chlorinated congeners can make up themajority of the total PCB body burden.