TY - JOUR
T1 - Multi-Functional Black Bioactive Glasses Prepared via Containerless Melting Process for Tumor Therapy and Tissue Regeneration
AU - Wang, E.D.
AU - Li, X.F.
AU - Zhang, Y.
AU - Ma, L.L.
AU - Xu, Q.
AU - Yue, Yuanzheng
AU - Wang, W.Z.
AU - Li, Q.
AU - Yu, J.D.
AU - Chang, J.
PY - 2021
Y1 - 2021
N2 - Tissue regeneration in complex lesions such as the site of tumors, bacterial infection, and sites lacking blood vessels, has been a huge challenge. Therefore, developing bioactive implantable materials with multi-functional properties such as tumor destruction, bacteria growth inhibition, and angiogenesis promotion is of great significance. In this study, black CaO-SiO2-TiO2 (CST) glasses are prepared through the containerless melting approach, by which heterogeneous nucleation can be avoided and thereby glass formation becomes possible via fast quenching. This approach enables the formation of trivalent titanium (Ti3+) without using a reducing atmosphere or reducing agents. The black CST glasses are found in this study to possess a strong ability to inhibit bacteria and tumors by their excellent photothermal and photocatalytic effects. Strikingly, these glasses also promote the formation of blood vessels and accelerate the healing of chronic wounds by the synergistic effects of the photothermal effect and Si ions. Thus, this glass system can be a promising multi-functional material for tissue regeneration in complex lesions.
AB - Tissue regeneration in complex lesions such as the site of tumors, bacterial infection, and sites lacking blood vessels, has been a huge challenge. Therefore, developing bioactive implantable materials with multi-functional properties such as tumor destruction, bacteria growth inhibition, and angiogenesis promotion is of great significance. In this study, black CaO-SiO2-TiO2 (CST) glasses are prepared through the containerless melting approach, by which heterogeneous nucleation can be avoided and thereby glass formation becomes possible via fast quenching. This approach enables the formation of trivalent titanium (Ti3+) without using a reducing atmosphere or reducing agents. The black CST glasses are found in this study to possess a strong ability to inhibit bacteria and tumors by their excellent photothermal and photocatalytic effects. Strikingly, these glasses also promote the formation of blood vessels and accelerate the healing of chronic wounds by the synergistic effects of the photothermal effect and Si ions. Thus, this glass system can be a promising multi-functional material for tissue regeneration in complex lesions.
KW - black titanium dioxide
KW - containerless melting process
KW - silicate bioglass
KW - tissue regeneration
KW - tumor therapy
UR - http://www.scopus.com/inward/record.url?scp=85104083505&partnerID=8YFLogxK
U2 - 10.1002/adfm.202101505
DO - 10.1002/adfm.202101505
M3 - Journal article
SN - 1616-301X
VL - 31
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 24
M1 - 2101505
ER -