A cautious iodization program bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population

Inge Bülow Pedersen, Nils Jakob Knudsen, Allan Carlé, Pernille Vejbjerg, Torben Jørgensen, Hans Perrild, Lars Ovesen, Lone Banke Rasmussen, Peter Laurberg

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124 Citationer (Scopus)

Abstract

Autoantibodies against the thyroid gland with thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) as the most common can often be demonstrated in serum. The effect of public iodization programs on antibody prevalence is uncertain. Aim:  To measure concentrations of thyroid autoantibodies in the Danish population before and after mandatory iodization of salt. Methods:  Two identical cross-sectional population studies were performed before (Cohort 1 (C1), year 1997-1998, n = 4649, median urinary iodine 61 μg/l) and 4-5 years after (Cohort 2 (C2), year 2004-2005, n = 3570, median urinary iodine 101 μg/l) mandatory iodine fortification of salt was implemented in Denmark. Blood tests were analysed for TPO-Ab and Tg-Ab using sensitive assays. Results:  Antibodies were more frequent in C2 than in C1: TPO-Ab > 30 U/ml, C1 vs. C2: 14.3 vs. 23.8% (p <0.001); Tg-Ab > 20 U/ml, C1 vs. C2: 13.7 vs. 19.9% (p <0.001). The C2 vs. C1 effect was confirmed in multivariate regression models (C1 reference): TPO-Ab: OR (95% CI): 1.80 (1.59-2.04); Tg-Ab: 1.49 (1.31-1.69). The increase in frequency of thyroid antibodies was most pronounced in young females and especially observed at low concentrations of antibodies. Conclusion:  The prevalence of both TPO-Ab and Tg-Ab was higher 4-5 years after a cautious iodine fortification of salt was introduced in Denmark. The increase was most pronounced in young females and in the low concentrations of antibody. Further studies are needed to evaluate the long-term effects of increased iodine intake on thyroid autoimmunity in the population.
OriginalsprogEngelsk
TidsskriftClinical Endocrinology
Vol/bind75
Udgave nummer1
Sider (fra-til)120-126
ISSN0300-0664
DOI
StatusUdgivet - 2011
Udgivet eksterntJa

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