A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma

Annette Juul Vangsted; Kaspar Renÿ Nielsen; Tobias Wirenfeldt Klausen; Einar Haukaas; Anne Tjønneland; Ulla Vogel

doi:10.1111/j.1365-2141.2012.09141.x

A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma

Annette Juul Vangsted, Kaspar Renÿ Nielsen, Tobias Wirenfeldt Klausen, Einar Haukaas, Anne Tjønneland, Ulla Vogel

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

23 Citationer (Scopus)

Abstract

The cytokine interleukin-1β (IL1B) is important for anti-tumour immune response. Genetic variation may modify the expression of IL1B and thereby influence the risk of disease. We investigated genetic variations with functional importance in the IL1B and NFKB1 genes in 348 population-based samples of multiple myeloma (MM) and a random sample of 1700 individuals. Carriers of the variant T-allele IL1B C-3737T and carriers of the TGT haplotype were at lower risk of MM [relative risk (RR) 0·58 (95% confidence interval (CI) = 0·41-0·84) and RR 0·59 (95%CI 0·40-0·85), respectively]. No association with risk of MM was found for the NFKB1- 94 ins/del polymorphism.

Originalsprog	Engelsk
Tidsskrift	British Journal of Haematology. Supplement
Vol/bind	158
Sider (fra-til)	515-8
Antal sider	4
ISSN	0963-1860
DOI	https://doi.org/10.1111/j.1365-2141.2012.09141.x
Status	Udgivet - aug. 2012
Udgivet eksternt	Ja

Adgang til dokumentet

10.1111/j.1365-2141.2012.09141.x

AUB Link

Søg efter materialet i Aalborg Universitetsbiblioteks søgemaskine

Citationsformater

@article{b527817dd3b446798a49710503f1cc8b,

title = "A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma",

abstract = "The cytokine interleukin-1β (IL1B) is important for anti-tumour immune response. Genetic variation may modify the expression of IL1B and thereby influence the risk of disease. We investigated genetic variations with functional importance in the IL1B and NFKB1 genes in 348 population-based samples of multiple myeloma (MM) and a random sample of 1700 individuals. Carriers of the variant T-allele IL1B C-3737T and carriers of the TGT haplotype were at lower risk of MM [relative risk (RR) 0·58 (95% confidence interval (CI) = 0·41-0·84) and RR 0·59 (95%CI 0·40-0·85), respectively]. No association with risk of MM was found for the NFKB1- 94 ins/del polymorphism.",

keywords = "Case-Control Studies, Female, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Interleukin-1beta, Male, Multiple Myeloma, NF-kappa B p50 Subunit, Polymorphism, Single Nucleotide, Promoter Regions, Genetic",

author = "Vangsted, {Annette Juul} and Nielsen, {Kaspar Ren{\"y}} and Klausen, {Tobias Wirenfeldt} and Einar Haukaas and Anne Tj{\o}nneland and Ulla Vogel",

note = "{\textcopyright} 2012 Blackwell Publishing Ltd.",

year = "2012",

month = aug,

doi = "10.1111/j.1365-2141.2012.09141.x",

language = "English",

volume = "158",

pages = "515--8",

journal = "British Journal of Haematology. Supplement",

issn = "0963-1860",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma

AU - Vangsted, Annette Juul

AU - Nielsen, Kaspar Renÿ

AU - Klausen, Tobias Wirenfeldt

AU - Haukaas, Einar

AU - Tjønneland, Anne

AU - Vogel, Ulla

PY - 2012/8

Y1 - 2012/8

N2 - The cytokine interleukin-1β (IL1B) is important for anti-tumour immune response. Genetic variation may modify the expression of IL1B and thereby influence the risk of disease. We investigated genetic variations with functional importance in the IL1B and NFKB1 genes in 348 population-based samples of multiple myeloma (MM) and a random sample of 1700 individuals. Carriers of the variant T-allele IL1B C-3737T and carriers of the TGT haplotype were at lower risk of MM [relative risk (RR) 0·58 (95% confidence interval (CI) = 0·41-0·84) and RR 0·59 (95%CI 0·40-0·85), respectively]. No association with risk of MM was found for the NFKB1- 94 ins/del polymorphism.

AB - The cytokine interleukin-1β (IL1B) is important for anti-tumour immune response. Genetic variation may modify the expression of IL1B and thereby influence the risk of disease. We investigated genetic variations with functional importance in the IL1B and NFKB1 genes in 348 population-based samples of multiple myeloma (MM) and a random sample of 1700 individuals. Carriers of the variant T-allele IL1B C-3737T and carriers of the TGT haplotype were at lower risk of MM [relative risk (RR) 0·58 (95% confidence interval (CI) = 0·41-0·84) and RR 0·59 (95%CI 0·40-0·85), respectively]. No association with risk of MM was found for the NFKB1- 94 ins/del polymorphism.

KW - Case-Control Studies

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Interleukin-1beta

KW - Male

KW - Multiple Myeloma

KW - NF-kappa B p50 Subunit

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

U2 - 10.1111/j.1365-2141.2012.09141.x

DO - 10.1111/j.1365-2141.2012.09141.x

M3 - Journal article

SN - 0963-1860

VL - 158

SP - 515

EP - 518

JO - British Journal of Haematology. Supplement

JF - British Journal of Haematology. Supplement

ER -

A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma

Abstract

Adgang til dokumentet

AUB Link

Fingeraftryk

Citationsformater