A serosurvey examining exposure to Borrelia burgdorferi sensu lato and tick-borne encephalitis virus in Danish blood donors, August 2022

Mette Frimodt Hansen, Rosa Maja Møhring Gynthersen, Lukas Frans Ocias, Camilla Adler Sørensen, Bitten Aagaard Jensen, Christian Erikstrup, Dorte Kinggaard Holm, Susanne Gjørup Sækmose, Lene Holm Harritshøj, Linda Kolstad, Tove Hoffman, Åke Lundkvist, Helene Mens, Anne-Mette Lebech, Karen Angeliki Krogfelt*

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Abstract

OBJECTIVES: Borrelia burgdorferi sensu lato (Bbsl) and tick-borne encephalitis virus (TBEV) are tick-borne pathogens. This study aimed to investigate the seroprevalence of these pathogens in Danish blood donors.

METHODS: A total of 1000 plasma samples equally distributed (n = 200) from all five Danish regions were analyzed. Commercially available enzyme-linked immunosorbent assays were used to screen the samples for immunoglobulin G antibodies against Bbsl and TBEV. The samples positive for antibodies against TBEV were further examined with a commercially available enzyme-linked immunosorbent assay and a Luminex-based TBEV suspension multiplex immunoassay for specific antibodies against non-structural protein 1 (NS1) antigen suggestive of previous infection.

RESULTS: A total of 62 samples tested positive for immunoglobulin G antibodies against Bbsl. A total of 40 samples were positive or borderline for antibodies against TBEV, indicating potential infection or vaccination. Of these, one had antibodies against NS1, indicating past infection. The seroprevalence of Bbsl was 6.2% (95% confidence interval 4.8-7.8), with equal seroprevalence in all five regions. The seroprevalence of TBEV was 0.1% (95% confidence interval 0.01-0.62%).

CONCLUSIONS: The seroprevalence of Bbsl was similar throughout the country and corresponds well with previous studies. The seroprevalence of TBEV NS1 was low, which is in line with a low number of reported tick-borne encephalitis cases in Denmark. The NS1 positive sample was from the Capital Region, an endemic TBEV area.

OriginalsprogEngelsk
Artikelnummer100414
TidsskriftIJID regions
Vol/bind12
Antal sider5
ISSN2772-7076
DOI
StatusUdgivet - sep. 2024

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© 2024 The Author(s).

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