A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

Laure Yatime, Nicolas S Merle, Annette G Hansen, Niels Anton Friis, Jakob A Østergaard, Mette Bjerre, Lubka T Roumenina, Steffen Thiel, Peter Kristensen, Gregers R Andersen

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OriginalsprogEngelsk
Artikelnummer02822
TidsskriftFrontiers in Immunology
Vol/bind9
Udgave nummerNOV
Antal sider11
DOI
StatusUdgivet - 2018

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Single-Domain Antibodies
Complement C5
Staphylococcus aureus
Complement Membrane Attack Complex
Hemolysis
Proteins
Erythrocytes
Paroxysmal Hemoglobinuria
Complement Activation
Bacteriophages
Complement System Proteins
Therapeutics
staphylococcal exotoxin 1
Antibodies
Health
Infection
Pharmaceutical Preparations

Citer dette

Yatime, Laure ; Merle, Nicolas S ; Hansen, Annette G ; Friis, Niels Anton ; Østergaard, Jakob A ; Bjerre, Mette ; Roumenina, Lubka T ; Thiel, Steffen ; Kristensen, Peter ; Andersen, Gregers R. / A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein. I: Frontiers in Immunology. 2018 ; Bind 9, Nr. NOV.
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keywords = "Bacteriolysis, Complement, Hemolysis, Paroxysmal nocturnal hemoglobinuria, Pathogen mimicry, Single-domain antibody, Terminal pathway inhibition",
author = "Laure Yatime and Merle, {Nicolas S} and Hansen, {Annette G} and Friis, {Niels Anton} and {\O}stergaard, {Jakob A} and Mette Bjerre and Roumenina, {Lubka T} and Steffen Thiel and Peter Kristensen and Andersen, {Gregers R}",
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doi = "10.3389/fimmu.2018.02822",
language = "English",
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journal = "Frontiers in Immunology",
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A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein. / Yatime, Laure; Merle, Nicolas S; Hansen, Annette G; Friis, Niels Anton; Østergaard, Jakob A; Bjerre, Mette; Roumenina, Lubka T; Thiel, Steffen; Kristensen, Peter; Andersen, Gregers R.

I: Frontiers in Immunology, Bind 9, Nr. NOV, 02822, 2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

AU - Yatime, Laure

AU - Merle, Nicolas S

AU - Hansen, Annette G

AU - Friis, Niels Anton

AU - Østergaard, Jakob A

AU - Bjerre, Mette

AU - Roumenina, Lubka T

AU - Thiel, Steffen

AU - Kristensen, Peter

AU - Andersen, Gregers R

PY - 2018

Y1 - 2018

KW - Bacteriolysis

KW - Complement

KW - Hemolysis

KW - Paroxysmal nocturnal hemoglobinuria

KW - Pathogen mimicry

KW - Single-domain antibody

KW - Terminal pathway inhibition

UR - http://www.scopus.com/inward/record.url?scp=85057611268&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2018.02822

DO - 10.3389/fimmu.2018.02822

M3 - Journal article

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - NOV

M1 - 02822

ER -