A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa

Anders B Sorensen; Per Jr Greisen; Jesper J Madsen; Jacob Lund; Gorm Andersen; Pernille G Wulff-Larsen; Anette A Pedersen; Prafull S Gandhi; Michael T Overgaard; Henrik Østergaard; Ole H Olsen

doi:10.1038/s41598-022-07620-7

A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa

Anders B Sorensen, Per Jr Greisen, Jesper J Madsen, Jacob Lund, Gorm Andersen, Pernille G Wulff-Larsen, Anette A Pedersen, Prafull S Gandhi, Michael T Overgaard, Henrik Østergaard, Ole H Olsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Originalsprog	Engelsk
Artikelnummer	3747
Tidsskrift	Scientific Reports
Vol/bind	12
Udgave nummer	1
Sider (fra-til)	3747
ISSN	2045-2322
DOI	https://doi.org/10.1038/s41598-022-07620-7
Status	Udgivet - 8 mar. 2022

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10.1038/s41598-022-07620-7Licens: CC BY 4.0

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Sorensen, A. B., Greisen, P. J., Madsen, J. J., Lund, J., Andersen, G., Wulff-Larsen, P. G., Pedersen, A. A., Gandhi, P. S., Overgaard, M. T., Østergaard, H., & Olsen, O. H. (2022). A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa. Scientific Reports, 12(1), 3747. [3747]. https://doi.org/10.1038/s41598-022-07620-7

Sorensen, Anders B ; Greisen, Per Jr ; Madsen, Jesper J ; Lund, Jacob ; Andersen, Gorm ; Wulff-Larsen, Pernille G ; Pedersen, Anette A ; Gandhi, Prafull S ; Overgaard, Michael T ; Østergaard, Henrik ; Olsen, Ole H. / A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa. I: Scientific Reports. 2022 ; Bind 12, Nr. 1. s. 3747.

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title = "A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa",

keywords = "Factor VIIa, Serine Endopeptidases/metabolism, Substrate Specificity, Trypsin/metabolism",

author = "Sorensen, {Anders B} and Greisen, {Per Jr} and Madsen, {Jesper J} and Jacob Lund and Gorm Andersen and Wulff-Larsen, {Pernille G} and Pedersen, {Anette A} and Gandhi, {Prafull S} and Overgaard, {Michael T} and Henrik {\O}stergaard and Olsen, {Ole H}",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

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doi = "10.1038/s41598-022-07620-7",

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journal = "Scientific Reports",

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Sorensen, AB, Greisen, PJ, Madsen, JJ, Lund, J, Andersen, G, Wulff-Larsen, PG, Pedersen, AA, Gandhi, PS, Overgaard, MT, Østergaard, H & Olsen, OH 2022, 'A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa', Scientific Reports, bind 12, nr. 1, 3747, s. 3747. https://doi.org/10.1038/s41598-022-07620-7

A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa. / Sorensen, Anders B; Greisen, Per Jr; Madsen, Jesper J; Lund, Jacob; Andersen, Gorm; Wulff-Larsen, Pernille G; Pedersen, Anette A; Gandhi, Prafull S; Overgaard, Michael T; Østergaard, Henrik; Olsen, Ole H.

I: Scientific Reports, Bind 12, Nr. 1, 3747, 08.03.2022, s. 3747.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa

AU - Sorensen, Anders B

AU - Greisen, Per Jr

AU - Madsen, Jesper J

AU - Lund, Jacob

AU - Andersen, Gorm

AU - Wulff-Larsen, Pernille G

AU - Pedersen, Anette A

AU - Gandhi, Prafull S

AU - Overgaard, Michael T

AU - Østergaard, Henrik

AU - Olsen, Ole H

PY - 2022/3/8

Y1 - 2022/3/8

KW - Factor VIIa

KW - Serine Endopeptidases/metabolism

KW - Substrate Specificity

KW - Trypsin/metabolism

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U2 - 10.1038/s41598-022-07620-7

DO - 10.1038/s41598-022-07620-7

M3 - Journal article

C2 - 35260627

VL - 12

SP - 3747

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 3747

ER -

A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa

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