Absence of somatostatin receptor expression in vivo is correlated to di- or tetraploid 1p36-deleted neuroblastomas

Freimut H. Schilling; Peter F. Ambros; Heiner Bihl; Tommy Martinsson; Inge M. Ambros; Per Borgström; Hans Jacobsson; Ursula G. Falkmer; Jörn Treuner; Per Kogner

doi:10.1002/1096-911X(20010101)36:1<56::AID-MPO1015>3.0.CO;2-1

Absence of somatostatin receptor expression in vivo is correlated to di- or tetraploid 1p36-deleted neuroblastomas

Freimut H. Schilling^*, Peter F. Ambros, Heiner Bihl, Tommy Martinsson, Inge M. Ambros, Per Borgström, Hans Jacobsson, Ursula G. Falkmer, Jörn Treuner, Per Kogner

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Abstract

BACKGROUND: Poor prognosis in childhood neuroblastoma is associated with deletions of chromosome region 1p36 and di/tetraploid DNA content.

PROCEDURE: Forty-six patients with histopathologically proven neuroblastoma were investigated for in vivo expression of somatostatin receptors (SR) by 111In-pentetreotide scintigraphy. All tumors were analyzed for cytometric DNA content and chromosome 1p36 integrity.

RESULTS: SR expression was detected in 28 tumors (61%) and correlated with young age, localized clinical stage, and favorable outcome. Fourteen tumors showed deletion at chromosome 1p36, thirteen of which did not show SR expression (P< 0.001). A triploid DNA content was correlated with the presence of SR (23 of 25, P< 0.001). No tumor with deletion of chromosome 1p36 and di/tetra DNA content showed SR expression (chi2 = 29.88, d.o.f. = 2, P < 0.001).

CONCLUSIONS: We conclude that SR expression is related to genetic features of prognostic significance. This may be assessed with a minimally invasive scintigraphic method.

Originalsprog	Engelsk
Tidsskrift	Medical and pediatric oncology
Vol/bind	36
Udgave nummer	1
Sider (fra-til)	56-60
Antal sider	5
ISSN	0098-1532
DOI	https://doi.org/10.1002/1096-911X(20010101)36:1<56::AID-MPO1015>3.0.CO;2-1
Status	Udgivet - 10 jan. 2001
Udgivet eksternt	Ja

Adgang til dokumentet

10.1002/1096-911X(20010101)36:1<56::AID-MPO1015>3.0.CO;2-1

AUB Link

Søg efter materialet i Aalborg Universitetsbiblioteks søgemaskine

Citationsformater

Schilling, F. H., Ambros, P. F., Bihl, H., Martinsson, T., Ambros, I. M., Borgström, P., Jacobsson, H., Falkmer, U. G., Treuner, J., & Kogner, P. (2001). Absence of somatostatin receptor expression in vivo is correlated to di- or tetraploid 1p36-deleted neuroblastomas. Medical and pediatric oncology, 36(1), 56-60. https://doi.org/10.1002/1096-911X(20010101)36:1<56::AID-MPO1015>3.0.CO;2-1

@article{9fe88a9f74184839b313e7e61c65ea17,

title = "Absence of somatostatin receptor expression in vivo is correlated to di- or tetraploid 1p36-deleted neuroblastomas",

abstract = "BACKGROUND: Poor prognosis in childhood neuroblastoma is associated with deletions of chromosome region 1p36 and di/tetraploid DNA content.PROCEDURE: Forty-six patients with histopathologically proven neuroblastoma were investigated for in vivo expression of somatostatin receptors (SR) by 111In-pentetreotide scintigraphy. All tumors were analyzed for cytometric DNA content and chromosome 1p36 integrity.RESULTS: SR expression was detected in 28 tumors (61%) and correlated with young age, localized clinical stage, and favorable outcome. Fourteen tumors showed deletion at chromosome 1p36, thirteen of which did not show SR expression (P< 0.001). A triploid DNA content was correlated with the presence of SR (23 of 25, P< 0.001). No tumor with deletion of chromosome 1p36 and di/tetra DNA content showed SR expression (chi2 = 29.88, d.o.f. = 2, P < 0.001).CONCLUSIONS: We conclude that SR expression is related to genetic features of prognostic significance. This may be assessed with a minimally invasive scintigraphic method.",

keywords = "Adolescent, Age Factors, Aneuploidy, Child, Child, Preschool, Chromosome Deletion, Chromosomes, Human, Pair 1/genetics, DNA, Neoplasm/genetics, Female, Gene Expression Regulation, Neoplastic, Humans, In Situ Hybridization, Fluorescence, Indium Radioisotopes, Infant, Loss of Heterozygosity, Male, Neoplasm Proteins/analysis, Neoplasm Staging, Neuroblastoma/diagnostic imaging, Prognosis, Radionuclide Imaging, Receptors, Somatostatin/analysis, Somatostatin/analogs & derivatives",

author = "Schilling, {Freimut H.} and Ambros, {Peter F.} and Heiner Bihl and Tommy Martinsson and Ambros, {Inge M.} and Per Borgstr{\"o}m and Hans Jacobsson and Falkmer, {Ursula G.} and J{\"o}rn Treuner and Per Kogner",

year = "2001",

month = jan,

day = "10",

doi = "10.1002/1096-911X(20010101)36:1<56::AID-MPO1015>3.0.CO;2-1",

language = "English",

volume = "36",

pages = "56--60",

journal = "Medical and pediatric oncology",

issn = "0098-1532",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

Schilling, FH, Ambros, PF, Bihl, H, Martinsson, T, Ambros, IM, Borgström, P, Jacobsson, H, Falkmer, UG, Treuner, J & Kogner, P 2001, 'Absence of somatostatin receptor expression in vivo is correlated to di- or tetraploid 1p36-deleted neuroblastomas', Medical and pediatric oncology, bind 36, nr. 1, s. 56-60. https://doi.org/10.1002/1096-911X(20010101)36:1<56::AID-MPO1015>3.0.CO;2-1

TY - JOUR

T1 - Absence of somatostatin receptor expression in vivo is correlated to di- or tetraploid 1p36-deleted neuroblastomas

AU - Schilling, Freimut H.

AU - Ambros, Peter F.

AU - Bihl, Heiner

AU - Martinsson, Tommy

AU - Ambros, Inge M.

AU - Borgström, Per

AU - Jacobsson, Hans

AU - Falkmer, Ursula G.

AU - Treuner, Jörn

AU - Kogner, Per

PY - 2001/1/10

Y1 - 2001/1/10

N2 - BACKGROUND: Poor prognosis in childhood neuroblastoma is associated with deletions of chromosome region 1p36 and di/tetraploid DNA content.PROCEDURE: Forty-six patients with histopathologically proven neuroblastoma were investigated for in vivo expression of somatostatin receptors (SR) by 111In-pentetreotide scintigraphy. All tumors were analyzed for cytometric DNA content and chromosome 1p36 integrity.RESULTS: SR expression was detected in 28 tumors (61%) and correlated with young age, localized clinical stage, and favorable outcome. Fourteen tumors showed deletion at chromosome 1p36, thirteen of which did not show SR expression (P< 0.001). A triploid DNA content was correlated with the presence of SR (23 of 25, P< 0.001). No tumor with deletion of chromosome 1p36 and di/tetra DNA content showed SR expression (chi2 = 29.88, d.o.f. = 2, P < 0.001).CONCLUSIONS: We conclude that SR expression is related to genetic features of prognostic significance. This may be assessed with a minimally invasive scintigraphic method.

AB - BACKGROUND: Poor prognosis in childhood neuroblastoma is associated with deletions of chromosome region 1p36 and di/tetraploid DNA content.PROCEDURE: Forty-six patients with histopathologically proven neuroblastoma were investigated for in vivo expression of somatostatin receptors (SR) by 111In-pentetreotide scintigraphy. All tumors were analyzed for cytometric DNA content and chromosome 1p36 integrity.RESULTS: SR expression was detected in 28 tumors (61%) and correlated with young age, localized clinical stage, and favorable outcome. Fourteen tumors showed deletion at chromosome 1p36, thirteen of which did not show SR expression (P< 0.001). A triploid DNA content was correlated with the presence of SR (23 of 25, P< 0.001). No tumor with deletion of chromosome 1p36 and di/tetra DNA content showed SR expression (chi2 = 29.88, d.o.f. = 2, P < 0.001).CONCLUSIONS: We conclude that SR expression is related to genetic features of prognostic significance. This may be assessed with a minimally invasive scintigraphic method.

KW - Adolescent

KW - Age Factors

KW - Aneuploidy

KW - Child

KW - Child, Preschool

KW - Chromosome Deletion

KW - Chromosomes, Human, Pair 1/genetics

KW - DNA, Neoplasm/genetics

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Indium Radioisotopes

KW - Infant

KW - Loss of Heterozygosity

KW - Male

KW - Neoplasm Proteins/analysis

KW - Neoplasm Staging

KW - Neuroblastoma/diagnostic imaging

KW - Prognosis

KW - Radionuclide Imaging

KW - Receptors, Somatostatin/analysis

KW - Somatostatin/analogs & derivatives

U2 - 10.1002/1096-911X(20010101)36:1<56::AID-MPO1015>3.0.CO;2-1

DO - 10.1002/1096-911X(20010101)36:1<56::AID-MPO1015>3.0.CO;2-1

M3 - Journal article

C2 - 11464907

SN - 0098-1532

VL - 36

SP - 56

EP - 60

JO - Medical and pediatric oncology

JF - Medical and pediatric oncology

IS - 1

ER -

Absence of somatostatin receptor expression in vivo is correlated to di- or tetraploid 1p36-deleted neuroblastomas

Abstract

Adgang til dokumentet

AUB Link

Fingeraftryk

Citationsformater