@article{4de62dd0dd5747c99cbdb3b47c1f3ff8,
title = "Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium",
abstract = "OBJECTIVE: The purpose of this study was to evaluate the pharmacokinetics of a single dose of Selenium (Se) from yeast given to humans with a habitual long-term daily intake at a supra-nutritional level. METHODS: Twelve healthy males with a daily supplemental intake of 300 microg Se as selenised yeast over 10 weeks were supplemented with a single dose of 327 microg as stable (77)Se incorporated into selenised yeast manufactured by the same standardised process (SelenoPrecise(R), Pharma Nord, Denmark). RESULTS: Absorption of Se from (77)Se-enriched yeast was 89+/-4% and the retention was 74+/-6%. The (77)Se excretion from the single-dose was 47+/-15 microg in urine and 37+/-13 microg in faeces. The maximum, enriched (77)Se concentration in plasma was 9.8+/-1.5 microg/l and the time to maximum was 9.2 hours. The plasma halftime of (77)Se was longer with increasing time; 1.7 days for the initial phase ((1/2)-2 days), 3.0 days for the middle phase (2-3 days) and 11.1 days for the later phase (3-14 days). CONCLUSION: The Se from the standardised Se-enriched yeast was well absorbed and retained in the body.",
author = "Susanne B{\"u}gel and Larsen, {Erik H} and Sloth, {Jens J} and Knut Flytlie and Kim Overvad and Steenberg, {Lars C} and Sven Moesgaard",
year = "2008",
doi = "10.3402/fnr.v52i0.1642",
language = "English",
volume = "52",
journal = "Food & Nutrition Research",
issn = "1654-6628",
publisher = "Co-Action Publishing",
}