Acute Endovascular Reperfusion Treatment in Patients with Ischemic Stroke and Large Vessel Occlusion, Denmark 2011-2017

Thomas Truelsen, Klaus Hansen, Grethe Andersen, Leif Sørensen, Charlotte Madsen, Anabel Diaz, Trine Stavngaard, Heidi H Hundborg, Joan Højgaard, Niels Hjort, Helle K Iversen, Søren P Johnsen, Claus Z Simonsen

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Resumé

Background and purpose: Acute endovascular reperfusion treatment (aERT) of stroke patients with large-vessel occlusions is efficacious and safe according to several clinical trials. Data on outcome and safety of aERT in daily clinical routine are warranted and, in this study, we present national data from Denmark during 2011–2017. Methods: National data for Denmark from 2011 to 2017 on all aERT procedures in patients with acute ischaemic stroke and computed tomography angiography/magnetic resonance angiography-verified large-vessel occlusion were derived from the Danish Stroke Registry, a national clinical quality registry to which reporting is mandatory for all hospitals treating stroke patients. Outcome (modified Rankin Scale score) after 3 months, including time of death, was assessed prospectively based on clinical examination or the Danish Civil Registration System. Results: During the 7 years of observation, a total of 1720 patients were treated with aERT. The annual number of procedures increased from 128 in 2011 to 409 in 2017. The median age was 70 years, 58% were males and median National Institutes of Health Stroke Scale score at baseline was 16. Median time from symptom onset to groin puncture was 238 min with a decreasing trend during the years. Successful recanalization was reported in 1306 (76%) patients. At 3-month follow-up, an modified Rankin Scale score of 0–2 was reported in 46% of patients, whereas 14% of patients had died. Conclusion: Routine data on aERT in acute ischaemic stroke in Denmark from 2011 to 2017 suggest that the procedure is safe and efficacious.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Neurology
Vol/bind26
Udgave nummer8
Sider (fra-til)1044-1050
Antal sider7
ISSN1351-5101
DOI
StatusUdgivet - aug. 2019

Fingerprint

Denmark
Reperfusion
Stroke
Therapeutics
Registries
Mandatory Reporting
Groin
Magnetic Resonance Angiography
National Institutes of Health (U.S.)
Punctures
Observation
Clinical Trials
Safety

Citer dette

Truelsen, T., Hansen, K., Andersen, G., Sørensen, L., Madsen, C., Diaz, A., ... Simonsen, C. Z. (2019). Acute Endovascular Reperfusion Treatment in Patients with Ischemic Stroke and Large Vessel Occlusion, Denmark 2011-2017. European Journal of Neurology, 26(8), 1044-1050. https://doi.org/10.1111/ene.13931
Truelsen, Thomas ; Hansen, Klaus ; Andersen, Grethe ; Sørensen, Leif ; Madsen, Charlotte ; Diaz, Anabel ; Stavngaard, Trine ; Hundborg, Heidi H ; Højgaard, Joan ; Hjort, Niels ; Iversen, Helle K ; Johnsen, Søren P ; Simonsen, Claus Z. / Acute Endovascular Reperfusion Treatment in Patients with Ischemic Stroke and Large Vessel Occlusion, Denmark 2011-2017. I: European Journal of Neurology. 2019 ; Bind 26, Nr. 8. s. 1044-1050.
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title = "Acute Endovascular Reperfusion Treatment in Patients with Ischemic Stroke and Large Vessel Occlusion, Denmark 2011-2017",
abstract = "Background and purpose: Acute endovascular reperfusion treatment (aERT) of stroke patients with large-vessel occlusions is efficacious and safe according to several clinical trials. Data on outcome and safety of aERT in daily clinical routine are warranted and, in this study, we present national data from Denmark during 2011–2017. Methods: National data for Denmark from 2011 to 2017 on all aERT procedures in patients with acute ischaemic stroke and computed tomography angiography/magnetic resonance angiography-verified large-vessel occlusion were derived from the Danish Stroke Registry, a national clinical quality registry to which reporting is mandatory for all hospitals treating stroke patients. Outcome (modified Rankin Scale score) after 3 months, including time of death, was assessed prospectively based on clinical examination or the Danish Civil Registration System. Results: During the 7 years of observation, a total of 1720 patients were treated with aERT. The annual number of procedures increased from 128 in 2011 to 409 in 2017. The median age was 70 years, 58{\%} were males and median National Institutes of Health Stroke Scale score at baseline was 16. Median time from symptom onset to groin puncture was 238 min with a decreasing trend during the years. Successful recanalization was reported in 1306 (76{\%}) patients. At 3-month follow-up, an modified Rankin Scale score of 0–2 was reported in 46{\%} of patients, whereas 14{\%} of patients had died. Conclusion: Routine data on aERT in acute ischaemic stroke in Denmark from 2011 to 2017 suggest that the procedure is safe and efficacious.",
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author = "Thomas Truelsen and Klaus Hansen and Grethe Andersen and Leif S{\o}rensen and Charlotte Madsen and Anabel Diaz and Trine Stavngaard and Hundborg, {Heidi H} and Joan H{\o}jgaard and Niels Hjort and Iversen, {Helle K} and Johnsen, {S{\o}ren P} and Simonsen, {Claus Z}",
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Truelsen, T, Hansen, K, Andersen, G, Sørensen, L, Madsen, C, Diaz, A, Stavngaard, T, Hundborg, HH, Højgaard, J, Hjort, N, Iversen, HK, Johnsen, SP & Simonsen, CZ 2019, 'Acute Endovascular Reperfusion Treatment in Patients with Ischemic Stroke and Large Vessel Occlusion, Denmark 2011-2017', European Journal of Neurology, bind 26, nr. 8, s. 1044-1050. https://doi.org/10.1111/ene.13931

Acute Endovascular Reperfusion Treatment in Patients with Ischemic Stroke and Large Vessel Occlusion, Denmark 2011-2017. / Truelsen, Thomas; Hansen, Klaus; Andersen, Grethe; Sørensen, Leif; Madsen, Charlotte; Diaz, Anabel; Stavngaard, Trine; Hundborg, Heidi H; Højgaard, Joan; Hjort, Niels; Iversen, Helle K; Johnsen, Søren P; Simonsen, Claus Z.

I: European Journal of Neurology, Bind 26, Nr. 8, 08.2019, s. 1044-1050.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Acute Endovascular Reperfusion Treatment in Patients with Ischemic Stroke and Large Vessel Occlusion, Denmark 2011-2017

AU - Truelsen, Thomas

AU - Hansen, Klaus

AU - Andersen, Grethe

AU - Sørensen, Leif

AU - Madsen, Charlotte

AU - Diaz, Anabel

AU - Stavngaard, Trine

AU - Hundborg, Heidi H

AU - Højgaard, Joan

AU - Hjort, Niels

AU - Iversen, Helle K

AU - Johnsen, Søren P

AU - Simonsen, Claus Z

N1 - © 2019 EAN.

PY - 2019/8

Y1 - 2019/8

N2 - Background and purpose: Acute endovascular reperfusion treatment (aERT) of stroke patients with large-vessel occlusions is efficacious and safe according to several clinical trials. Data on outcome and safety of aERT in daily clinical routine are warranted and, in this study, we present national data from Denmark during 2011–2017. Methods: National data for Denmark from 2011 to 2017 on all aERT procedures in patients with acute ischaemic stroke and computed tomography angiography/magnetic resonance angiography-verified large-vessel occlusion were derived from the Danish Stroke Registry, a national clinical quality registry to which reporting is mandatory for all hospitals treating stroke patients. Outcome (modified Rankin Scale score) after 3 months, including time of death, was assessed prospectively based on clinical examination or the Danish Civil Registration System. Results: During the 7 years of observation, a total of 1720 patients were treated with aERT. The annual number of procedures increased from 128 in 2011 to 409 in 2017. The median age was 70 years, 58% were males and median National Institutes of Health Stroke Scale score at baseline was 16. Median time from symptom onset to groin puncture was 238 min with a decreasing trend during the years. Successful recanalization was reported in 1306 (76%) patients. At 3-month follow-up, an modified Rankin Scale score of 0–2 was reported in 46% of patients, whereas 14% of patients had died. Conclusion: Routine data on aERT in acute ischaemic stroke in Denmark from 2011 to 2017 suggest that the procedure is safe and efficacious.

AB - Background and purpose: Acute endovascular reperfusion treatment (aERT) of stroke patients with large-vessel occlusions is efficacious and safe according to several clinical trials. Data on outcome and safety of aERT in daily clinical routine are warranted and, in this study, we present national data from Denmark during 2011–2017. Methods: National data for Denmark from 2011 to 2017 on all aERT procedures in patients with acute ischaemic stroke and computed tomography angiography/magnetic resonance angiography-verified large-vessel occlusion were derived from the Danish Stroke Registry, a national clinical quality registry to which reporting is mandatory for all hospitals treating stroke patients. Outcome (modified Rankin Scale score) after 3 months, including time of death, was assessed prospectively based on clinical examination or the Danish Civil Registration System. Results: During the 7 years of observation, a total of 1720 patients were treated with aERT. The annual number of procedures increased from 128 in 2011 to 409 in 2017. The median age was 70 years, 58% were males and median National Institutes of Health Stroke Scale score at baseline was 16. Median time from symptom onset to groin puncture was 238 min with a decreasing trend during the years. Successful recanalization was reported in 1306 (76%) patients. At 3-month follow-up, an modified Rankin Scale score of 0–2 was reported in 46% of patients, whereas 14% of patients had died. Conclusion: Routine data on aERT in acute ischaemic stroke in Denmark from 2011 to 2017 suggest that the procedure is safe and efficacious.

KW - cerebral circulation

KW - cerebrovascular disease

KW - endovascular procedures

KW - epidemiology

KW - management

KW - neurologic disorders

KW - research methods

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85063103857&partnerID=8YFLogxK

U2 - 10.1111/ene.13931

DO - 10.1111/ene.13931

M3 - Journal article

VL - 26

SP - 1044

EP - 1050

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 8

ER -