Acute pancreatitis as an early marker of pancreatic cancer and cancer stage, treatment, and prognosis

Jakob Kirkegård, Charles Gaber, Jennifer L Lund, Sharon P Hinton, Morten Ladekarl, Uffe Heide-Jørgensen, Deirdre Cronin-Fenton, Frank V Mortensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: We aimed to examine the association between acute pancreatitis, a potential early symptom of pancreatic cancer, and pancreatic cancer stage, treatment, and prognosis.

METHODS: We conducted a cohort study of patients diagnosed with pancreatic cancer during 2004-2017 using population-based registry data from Denmark and Surveillance, Epidemiology, and End Results (SEER) data linked with Medicare claims from the United States (US), which include individuals aged 65 + . We ascertained information on acute pancreatitis diagnoses up to 90 days before pancreatic cancer and followed them for a maximum of five years. We assessed overall survival difference at 30 days, six months, and one, three and five years, comparing patients with and without coexistence of acute pancreatitis. Secondary outcomes were cancer stage and treatment.

RESULTS: We identified 12,522 Danish and 37,552 US patients with pancreatic cancer (median age 71 and 78 years, respectively). In the Danish cohort, 1.4 % had acute pancreatitis before pancreatic cancer vs. 5.9 % in the US cohort. After five years of follow-up, the survival difference was 6.1 % (95 % CI: [-0.4 %, 12.6 %]) in Danish and 1.7 % (95 % CI: [0.8 %, 2.7 %]) in US patients, comparing patients with and without acute pancreatitis. Patients with acute pancreatitis had lower prevalence of metastatic tumors at diagnosis (Denmark: 42.5 % vs. 48.7 %; US: 34.4 % vs. 45.9 %) and higher resection frequencies (Denmark: 20.1 % vs. 12.1 %; US: 16.1 % vs.11.3 %) than patients without acute pancreatitis.

CONCLUSIONS: Pancreatic cancer patients with acute pancreatitis diagnosed up to 90 days before cancer diagnosis had earlier stage at diagnosis and better survival than patients without acute pancreatitis.

OriginalsprogEngelsk
Artikelnummer101647
TidsskriftCancer epidemiology
Vol/bind64
Antal sider9
ISSN1877-7821
DOI
StatusUdgivet - 2020

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Pancreatic Neoplasms
Pancreatitis
Neoplasms
Denmark
Therapeutics
Survival
Medicare
Early Detection of Cancer
Registries
Epidemiology
Cohort Studies
Population

Citer dette

Kirkegård, J., Gaber, C., Lund, J. L., Hinton, S. P., Ladekarl, M., Heide-Jørgensen, U., ... Mortensen, F. V. (2020). Acute pancreatitis as an early marker of pancreatic cancer and cancer stage, treatment, and prognosis. Cancer epidemiology, 64, [101647]. https://doi.org/10.1016/j.canep.2019.101647
Kirkegård, Jakob ; Gaber, Charles ; Lund, Jennifer L ; Hinton, Sharon P ; Ladekarl, Morten ; Heide-Jørgensen, Uffe ; Cronin-Fenton, Deirdre ; Mortensen, Frank V. / Acute pancreatitis as an early marker of pancreatic cancer and cancer stage, treatment, and prognosis. I: Cancer epidemiology. 2020 ; Bind 64.
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title = "Acute pancreatitis as an early marker of pancreatic cancer and cancer stage, treatment, and prognosis",
abstract = "BACKGROUND: We aimed to examine the association between acute pancreatitis, a potential early symptom of pancreatic cancer, and pancreatic cancer stage, treatment, and prognosis.METHODS: We conducted a cohort study of patients diagnosed with pancreatic cancer during 2004-2017 using population-based registry data from Denmark and Surveillance, Epidemiology, and End Results (SEER) data linked with Medicare claims from the United States (US), which include individuals aged 65 + . We ascertained information on acute pancreatitis diagnoses up to 90 days before pancreatic cancer and followed them for a maximum of five years. We assessed overall survival difference at 30 days, six months, and one, three and five years, comparing patients with and without coexistence of acute pancreatitis. Secondary outcomes were cancer stage and treatment.RESULTS: We identified 12,522 Danish and 37,552 US patients with pancreatic cancer (median age 71 and 78 years, respectively). In the Danish cohort, 1.4 {\%} had acute pancreatitis before pancreatic cancer vs. 5.9 {\%} in the US cohort. After five years of follow-up, the survival difference was 6.1 {\%} (95 {\%} CI: [-0.4 {\%}, 12.6 {\%}]) in Danish and 1.7 {\%} (95 {\%} CI: [0.8 {\%}, 2.7 {\%}]) in US patients, comparing patients with and without acute pancreatitis. Patients with acute pancreatitis had lower prevalence of metastatic tumors at diagnosis (Denmark: 42.5 {\%} vs. 48.7 {\%}; US: 34.4 {\%} vs. 45.9 {\%}) and higher resection frequencies (Denmark: 20.1 {\%} vs. 12.1 {\%}; US: 16.1 {\%} vs.11.3 {\%}) than patients without acute pancreatitis.CONCLUSIONS: Pancreatic cancer patients with acute pancreatitis diagnosed up to 90 days before cancer diagnosis had earlier stage at diagnosis and better survival than patients without acute pancreatitis.",
author = "Jakob Kirkeg{\aa}rd and Charles Gaber and Lund, {Jennifer L} and Hinton, {Sharon P} and Morten Ladekarl and Uffe Heide-J{\o}rgensen and Deirdre Cronin-Fenton and Mortensen, {Frank V}",
year = "2020",
doi = "10.1016/j.canep.2019.101647",
language = "English",
volume = "64",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier",

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Kirkegård, J, Gaber, C, Lund, JL, Hinton, SP, Ladekarl, M, Heide-Jørgensen, U, Cronin-Fenton, D & Mortensen, FV 2020, 'Acute pancreatitis as an early marker of pancreatic cancer and cancer stage, treatment, and prognosis', Cancer epidemiology, bind 64, 101647. https://doi.org/10.1016/j.canep.2019.101647

Acute pancreatitis as an early marker of pancreatic cancer and cancer stage, treatment, and prognosis. / Kirkegård, Jakob; Gaber, Charles; Lund, Jennifer L; Hinton, Sharon P; Ladekarl, Morten; Heide-Jørgensen, Uffe; Cronin-Fenton, Deirdre; Mortensen, Frank V.

I: Cancer epidemiology, Bind 64, 101647, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Acute pancreatitis as an early marker of pancreatic cancer and cancer stage, treatment, and prognosis

AU - Kirkegård, Jakob

AU - Gaber, Charles

AU - Lund, Jennifer L

AU - Hinton, Sharon P

AU - Ladekarl, Morten

AU - Heide-Jørgensen, Uffe

AU - Cronin-Fenton, Deirdre

AU - Mortensen, Frank V

PY - 2020

Y1 - 2020

N2 - BACKGROUND: We aimed to examine the association between acute pancreatitis, a potential early symptom of pancreatic cancer, and pancreatic cancer stage, treatment, and prognosis.METHODS: We conducted a cohort study of patients diagnosed with pancreatic cancer during 2004-2017 using population-based registry data from Denmark and Surveillance, Epidemiology, and End Results (SEER) data linked with Medicare claims from the United States (US), which include individuals aged 65 + . We ascertained information on acute pancreatitis diagnoses up to 90 days before pancreatic cancer and followed them for a maximum of five years. We assessed overall survival difference at 30 days, six months, and one, three and five years, comparing patients with and without coexistence of acute pancreatitis. Secondary outcomes were cancer stage and treatment.RESULTS: We identified 12,522 Danish and 37,552 US patients with pancreatic cancer (median age 71 and 78 years, respectively). In the Danish cohort, 1.4 % had acute pancreatitis before pancreatic cancer vs. 5.9 % in the US cohort. After five years of follow-up, the survival difference was 6.1 % (95 % CI: [-0.4 %, 12.6 %]) in Danish and 1.7 % (95 % CI: [0.8 %, 2.7 %]) in US patients, comparing patients with and without acute pancreatitis. Patients with acute pancreatitis had lower prevalence of metastatic tumors at diagnosis (Denmark: 42.5 % vs. 48.7 %; US: 34.4 % vs. 45.9 %) and higher resection frequencies (Denmark: 20.1 % vs. 12.1 %; US: 16.1 % vs.11.3 %) than patients without acute pancreatitis.CONCLUSIONS: Pancreatic cancer patients with acute pancreatitis diagnosed up to 90 days before cancer diagnosis had earlier stage at diagnosis and better survival than patients without acute pancreatitis.

AB - BACKGROUND: We aimed to examine the association between acute pancreatitis, a potential early symptom of pancreatic cancer, and pancreatic cancer stage, treatment, and prognosis.METHODS: We conducted a cohort study of patients diagnosed with pancreatic cancer during 2004-2017 using population-based registry data from Denmark and Surveillance, Epidemiology, and End Results (SEER) data linked with Medicare claims from the United States (US), which include individuals aged 65 + . We ascertained information on acute pancreatitis diagnoses up to 90 days before pancreatic cancer and followed them for a maximum of five years. We assessed overall survival difference at 30 days, six months, and one, three and five years, comparing patients with and without coexistence of acute pancreatitis. Secondary outcomes were cancer stage and treatment.RESULTS: We identified 12,522 Danish and 37,552 US patients with pancreatic cancer (median age 71 and 78 years, respectively). In the Danish cohort, 1.4 % had acute pancreatitis before pancreatic cancer vs. 5.9 % in the US cohort. After five years of follow-up, the survival difference was 6.1 % (95 % CI: [-0.4 %, 12.6 %]) in Danish and 1.7 % (95 % CI: [0.8 %, 2.7 %]) in US patients, comparing patients with and without acute pancreatitis. Patients with acute pancreatitis had lower prevalence of metastatic tumors at diagnosis (Denmark: 42.5 % vs. 48.7 %; US: 34.4 % vs. 45.9 %) and higher resection frequencies (Denmark: 20.1 % vs. 12.1 %; US: 16.1 % vs.11.3 %) than patients without acute pancreatitis.CONCLUSIONS: Pancreatic cancer patients with acute pancreatitis diagnosed up to 90 days before cancer diagnosis had earlier stage at diagnosis and better survival than patients without acute pancreatitis.

U2 - 10.1016/j.canep.2019.101647

DO - 10.1016/j.canep.2019.101647

M3 - Journal article

C2 - 31811984

VL - 64

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

M1 - 101647

ER -