Adipose tissue content of alpha-linolenic acid and development of peripheral artery disease: a Danish case-cohort study

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Resumé

PURPOSE: The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD).

METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes.

RESULTS: During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84% (interquartile range 0.73-0.94%) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women.

CONCLUSIONS: We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Nutrition
ISSN1436-6207
DOI
StatusE-pub ahead of print - 12 dec. 2019

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alpha-Linolenic Acid
Peripheral Arterial Disease
Adipose Tissue
Cohort Studies
Fatty Acids
Buttocks
Omega-3 Fatty Acids
Gas Chromatography
Multivariate Analysis
Diet
Health
Neoplasms

Citer dette

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title = "Adipose tissue content of alpha-linolenic acid and development of peripheral artery disease: a Danish case-cohort study",
abstract = "PURPOSE: The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD).METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes.RESULTS: During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84{\%} (interquartile range 0.73-0.94{\%}) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women.CONCLUSIONS: We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.",
author = "Bork, {Christian S} and Lasota, {Anne N} and S{\o}ren Lundbye-Christensen and Jakobsen, {Marianne U} and Anne Tj{\o}nneland and Kim Overvad and Schmidt, {Erik B}",
year = "2019",
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day = "12",
doi = "10.1007/s00394-019-02159-2",
language = "English",
journal = "European Journal of Nutrition",
issn = "1436-6207",
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T1 - Adipose tissue content of alpha-linolenic acid and development of peripheral artery disease

T2 - a Danish case-cohort study

AU - Bork, Christian S

AU - Lasota, Anne N

AU - Lundbye-Christensen, Søren

AU - Jakobsen, Marianne U

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Schmidt, Erik B

PY - 2019/12/12

Y1 - 2019/12/12

N2 - PURPOSE: The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD).METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes.RESULTS: During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84% (interquartile range 0.73-0.94%) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women.CONCLUSIONS: We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.

AB - PURPOSE: The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD).METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes.RESULTS: During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84% (interquartile range 0.73-0.94%) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women.CONCLUSIONS: We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.

U2 - 10.1007/s00394-019-02159-2

DO - 10.1007/s00394-019-02159-2

M3 - Journal article

C2 - 31832750

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

ER -