Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity

A Comparison Between Schizophrenia and Obsessive-compulsive Disorder

Yongming Wang, Lai-quan Zou, Wen-lan Xie, Zhuo-ya Yang, Xiong-zhao Zhu, Eric F. C. Cheung, Thomas Alrik Sørensen, Arne Møller, Raymond C. K. Chan

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4 Citationer (Scopus)

Resumé

Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders.
OriginalsprogEngelsk
TidsskriftSchizophrenia Bulletin
Vol/bind45
Udgave nummer1
Sider (fra-til)199-210
Antal sider12
ISSN0586-7614
DOI
StatusUdgivet - 1 jan. 2019

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Obsessive-Compulsive Disorder
Comorbidity
Schizophrenia
Executive Function
Brain
Brain Diseases
Temporal Lobe
Mental Disorders
Neuroimaging

Citer dette

Wang, Yongming ; Zou, Lai-quan ; Xie, Wen-lan ; Yang, Zhuo-ya ; Zhu, Xiong-zhao ; Cheung, Eric F. C. ; Sørensen, Thomas Alrik ; Møller, Arne ; Chan, Raymond C. K. / Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity : A Comparison Between Schizophrenia and Obsessive-compulsive Disorder. I: Schizophrenia Bulletin. 2019 ; Bind 45, Nr. 1. s. 199-210.
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abstract = "Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders.",
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Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity : A Comparison Between Schizophrenia and Obsessive-compulsive Disorder. / Wang, Yongming; Zou, Lai-quan; Xie, Wen-lan ; Yang, Zhuo-ya ; Zhu, Xiong-zhao ; Cheung, Eric F. C. ; Sørensen, Thomas Alrik; Møller, Arne; Chan, Raymond C. K.

I: Schizophrenia Bulletin, Bind 45, Nr. 1, 01.01.2019, s. 199-210.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Altered Functional Connectivity of the Default Mode Network in Patients With Schizo-obsessive Comorbidity

T2 - A Comparison Between Schizophrenia and Obsessive-compulsive Disorder

AU - Wang, Yongming

AU - Zou, Lai-quan

AU - Xie, Wen-lan

AU - Yang, Zhuo-ya

AU - Zhu, Xiong-zhao

AU - Cheung, Eric F. C.

AU - Sørensen, Thomas Alrik

AU - Møller, Arne

AU - Chan, Raymond C. K.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders.

AB - Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups. In addition, compared with HCs, all 3 patient groups exhibited increased rsFC between subregions of the DMN and the executive control network (ECN). The SOC and SCZ group both exhibited increased rsFC between subregions of the DMN and the middle temporal gyrus, but the OCD group exhibited decreased rsFC between them. These findings highlight a specific alteration in functional connectivity in the DMN in patients with SOC, and provide new insights into the dysfunctional brain organization of different mental disorders.

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KW - schizophrenia

KW - obsessive-compulsive disorder

KW - functional connectivity

KW - default mode network

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