An Extension of ERODE to Reduce Boolean Networks By Backward Boolean Equivalence

Georgios Argyris, Alberto Lluch Lafuente, Mirco Tribastone, Max Tschaikowski, Andrea Vandin

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Abstract

Boolean Networks (BN) are established tools for modelling biological systems. However, their analysis is hindered by the state space explosion: the exponentially many states on the variables of a BN. We present an extension of the tool for model reduction ERODE with support for BNs and their reduction with a recent method called Backward Boolean Equivalence (BBE). BBE identifies maximal sets of variables that retain the same value whenever initialized equally. ERODE has been also extended to support importing and exporting between different formats and model repositories, enhancing interoperability with other tools
OriginalsprogEngelsk
TitelComputational Methods in Systems Biology (CMSB'2022)
ForlagSpringer
Publikationsdato2022
Sider294-301
ISBN (Trykt)978-3-031-15033-3
ISBN (Elektronisk)978-3-031-15034-0
DOI
StatusUdgivet - 2022
NavnLecture Notes in Computer Science
Vol/bindLNBI, volume 13447
ISSN0302-9743

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