An in-vitro system for closed loop neuromodulation of peripheral nerves

Mafalda Ribeiro, Leen Jabban, Felipe Rettore Andris, Thomas Gomes Norgaard Dos Santos Nielsen, Paulo R F Rocha, Benjamin Metcalfe

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Abstrakt

Current neuromodulation research relies heavily on in-vivo animal experiments for developing novel devices and paradigms, which can be costly, time-consuming, and ethically contentious. As an alternative to this, in-vitro systems are being developed for examining explanted tissue in a controlled environment. However, these systems are typically tailored for cellular studies. Thus, this paper describes the development of an in-vitro system for electrically recording and stimulating large animal nerves. This is demonstrated experimentally using explanted pig ulnar nerves, which show evoked compound action potentials (eCAPs) when stimulated. These eCAPs were examined both in the time and velocity domain at a baseline temperature of 20° C, and at temperatures increasing up to those seen in-vivo (37°C). The results highlight that as the temperature is increased within the in-vitro system, faster conduction velocities (CVs) similar to those present in-vivo can be observed. To our knowledge, this is the first time an in-vitro peripheral nerve system has been validated against in-vivo data, which is crucial for promoting more widespread adoption of such systems for the optimisation of neural interfaces.

OriginalsprogEngelsk
Titel2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Antal sider4
Vol/bind2022
ForlagIEEE
Publikationsdatojul. 2022
Sider2361-2364
ISBN (Trykt)978-1-7281-2783-5
ISBN (Elektronisk)978-1-7281-2782-8
DOI
StatusUdgivet - jul. 2022
Begivenhed44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) - Glasgow, Storbritannien
Varighed: 11 jul. 202215 jul. 2022
https://embc.embs.org/2022/

Konference

Konference44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Land/OmrådeStorbritannien
ByGlasgow
Periode11/07/202215/07/2022
Internetadresse
NavnI E E E Engineering in Medicine and Biology Society. Conference Proceedings
ISSN2375-7477

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