TY - JOUR
T1 - Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition
AU - Lahmann, Petra H
AU - Cust, Anne E
AU - Friedenreich, Christine M
AU - Schulz, Mandy
AU - Lukanova, Annekatrin
AU - Kaaks, Rudolf
AU - Lundin, Eva
AU - Tjønneland, Anne
AU - Halkjær, Jytte
AU - Severinsen, Marianne Tang
AU - Overvad, Kim
AU - Fournier, Agnès
AU - Chabbert-Buffet, Nathalie
AU - Clavel-Chapelon, Françoise
AU - Dossus, Laure
AU - Pischon, Tobias
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Naska, Androniki
AU - Palli, Domenico
AU - Grioni, Sara
AU - Mattiello, Amalia
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Redondo, María-Luisa
AU - Jakszyn, Paula
AU - Sánchez, María-José
AU - Tormo, María-José
AU - Ardanaz, Eva
AU - Arriola, Larraitz
AU - Manjer, Jonas
AU - Jirström, Karin
AU - Bueno-de-Mesquita, H Bas
AU - May, Anne M
AU - Peeters, Petra H M
AU - Onland-Moret, N Charlotte
AU - Bingham, Sheila
AU - Khaw, Kay-Tee
AU - Allen, Naomi E
AU - Spencer, Elizabeth
AU - Rinaldi, Sabina
AU - Slimani, Nadia
AU - Chajes, Véronique
AU - Michaud, Dominique
AU - Norat, Teresa
AU - Riboli, Elio
PY - 2010
Y1 - 2010
N2 - We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m(2), obesity (BMI >/= 30 kg/m(2)) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.
AB - We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m(2), obesity (BMI >/= 30 kg/m(2)) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.
U2 - 10.1002/ijc.24952
DO - 10.1002/ijc.24952
M3 - Journal article
SN - 0020-7136
VL - 126
SP - 2404
EP - 2415
JO - International Journal of Cancer
JF - International Journal of Cancer
ER -