Antifungal resistance in isolates of aspergillus from a pig farm

John Kerr White, Jeppe Lund Nielsen, Jan Struckmann Poulsen, Anne Mette Madsen*

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Abstrakt

Antibiotic resistance in fungal isolates is increasing on a global scale. Despite knowledge that pig farmers are occupationally exposed to infectious species of fungi, such as Aspergillus spp., little is known regarding their potential exposure to antifungal-resistant Aspergillus spp. The aim of this study is to obtain knowledge regarding the antifungal resistance profiles of isolates of Aspergillus species taken from different source materials—including airborne dust, surface dust, faeces, and straw—within a pig farm. The EUCAST broth microdilution method was used for testing antifungal resistance from 43 isolates of Aspergillus sampled in 3 periods inside a Danish pig farm. Seven species of Aspergillus were obtained, including A. candidus (n = 5), A. fumigatus (n = 5), A. glaucus (n = 13), A. nidulans (n = 2), A. niger (n = 15), A. terreus (n = 1), and A. versicolor (n = 2). Overall, 27.9% of the Aspergillus isolates displayed resistance against at least one antifungal, and 11.6% of Aspergillus isolates displayed resistance against multiple antifungals. The most abundant group exhibiting antifungal resistance was affiliated with the species A. niger, with isolates exhibiting resistance to itraconazole, voriconazole, and caspofungin. One isolate of A. glaucus and two isolates of A. versicolor were resistant to amphotericin B (MIC ≥ 2 mg/L amphotericin B). Antibiotic-resistant fungi were found on all three sampling days.

OriginalsprogEngelsk
Artikelnummer826
TidsskriftAtmosphere
Vol/bind12
Udgave nummer7
Antal sider12
DOI
StatusUdgivet - jul. 2021

Bibliografisk note

Funding Information:
Acknowledgments: The authors would like to thank Carla Viegas for providing the antifungal-resistant strains of A. fumigatus that were used in this study. In addition, the authors would like to thank the farmers for opening their doors to us. This study was supported by the National Research Centre for the Working Environment, the Danish Working Authority, and Aalborg University.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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