Approximate Reductions of Rational Dynamical Systems in CLUE

Antonio Jiménez-Pastor; Alexander Leguizamon-Robayo; Max Tschaikowski; Andrea Vandin

doi:10.1007/978-3-031-71671-3_9

Approximate Reductions of Rational Dynamical Systems in CLUE

Antonio Jiménez-Pastor, Alexander Leguizamon-Robayo^*, Max Tschaikowski, Andrea Vandin

^*Kontaktforfatter

Publikation: Bidrag til bog/antologi/rapport/konference proceeding › Konferenceartikel i proceeding › Forskning › peer review

Abstract

In life sciences, deriving insights from dynamical systems can be challenging due to the large number of state variables involved. To address this, model reduction techniques can be used to project the system onto a lower-dimensional state space. CLUE is a tool that computes exact reductions for rational systems of ordinary differential equations. In this paper, we present an extension of CLUE to include approximate reductions which allow for larger aggregating power at the expense of a bounded error. Additionally, our extension includes new functionalities such as an interface to the model database ODEBase repository and simulation techniques for exploratory analyses.

Originalsprog	Engelsk
Titel	Computational Methods in Systems Biology : 22nd International Conference, CMSB 2024, Pisa, Italy, September 16–18, 2024, Proceedings
Redaktører	Roberta Gori, Paolo Milazzo, Mirco Tribastone
Antal sider	9
Forlag	Springer
Publikationsdato	2024
Sider	108-116
ISBN (Trykt)	978-3-031-71670-6
ISBN (Elektronisk)	978-3-031-71671-3
DOI	https://doi.org/10.1007/978-3-031-71671-3_9
Status	Udgivet - 2024
Begivenhed	22nd International Conference on Computational Methods in Systems Biology, CMSB 2024 - Pisa, Italien Varighed: 16 sep. 2024 → 18 sep. 2024

Konference

Konference	22nd International Conference on Computational Methods in Systems Biology, CMSB 2024
Land/Område	Italien
By	Pisa
Periode	16/09/2024 → 18/09/2024

Navn	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Vol/bind	14971 LNCS
ISSN	0302-9743

Bibliografisk note

Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

Adgang til dokumentet

10.1007/978-3-031-71671-3_9

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Citationsformater

Jiménez-Pastor, A., Leguizamon-Robayo, A., Tschaikowski, M., & Vandin, A. (2024). Approximate Reductions of Rational Dynamical Systems in CLUE. I R. Gori, P. Milazzo, & M. Tribastone (red.), Computational Methods in Systems Biology: 22nd International Conference, CMSB 2024, Pisa, Italy, September 16–18, 2024, Proceedings (s. 108-116). Springer. https://doi.org/10.1007/978-3-031-71671-3_9

Jiménez-Pastor, Antonio ; Leguizamon-Robayo, Alexander ; Tschaikowski, Max et al. / Approximate Reductions of Rational Dynamical Systems in CLUE. Computational Methods in Systems Biology: 22nd International Conference, CMSB 2024, Pisa, Italy, September 16–18, 2024, Proceedings. red. / Roberta Gori ; Paolo Milazzo ; Mirco Tribastone. Springer, 2024. s. 108-116 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Bind 14971 LNCS).

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Jiménez-Pastor, A, Leguizamon-Robayo, A, Tschaikowski, M & Vandin, A 2024, Approximate Reductions of Rational Dynamical Systems in CLUE. i R Gori, P Milazzo & M Tribastone (red), Computational Methods in Systems Biology: 22nd International Conference, CMSB 2024, Pisa, Italy, September 16–18, 2024, Proceedings. Springer, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), bind 14971 LNCS, s. 108-116, 22nd International Conference on Computational Methods in Systems Biology, CMSB 2024, Pisa, Italien, 16/09/2024. https://doi.org/10.1007/978-3-031-71671-3_9

Approximate Reductions of Rational Dynamical Systems in CLUE. / Jiménez-Pastor, Antonio; Leguizamon-Robayo, Alexander; Tschaikowski, Max et al.
Computational Methods in Systems Biology: 22nd International Conference, CMSB 2024, Pisa, Italy, September 16–18, 2024, Proceedings. red. / Roberta Gori; Paolo Milazzo; Mirco Tribastone. Springer, 2024. s. 108-116 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Bind 14971 LNCS).

Publikation: Bidrag til bog/antologi/rapport/konference proceeding › Konferenceartikel i proceeding › Forskning › peer review

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Jiménez-Pastor A, Leguizamon-Robayo A, Tschaikowski M, Vandin A. Approximate Reductions of Rational Dynamical Systems in CLUE. I Gori R, Milazzo P, Tribastone M, red., Computational Methods in Systems Biology: 22nd International Conference, CMSB 2024, Pisa, Italy, September 16–18, 2024, Proceedings. Springer. 2024. s. 108-116. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Bind 14971 LNCS). doi: 10.1007/978-3-031-71671-3_9