Aquaporins in the spinal cord

Michael Krystian Oklinski, Mariusz T. Skowronski, Agnieszka Skowronska, Michael Rützler, Kirsten Nørgaard Jensen, John D. Nieland, Tae-Hwan Kwon, Søren Nielsen

Publikation: Bidrag til tidsskriftReview (oversigtsartikel)peer review

38 Citationer (Scopus)
256 Downloads (Pure)

Abstract

Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer's disease and Parkinson's disease. The objective of this review is to highlight the current knowledge about AQPs in the spinal cord and their proposed roles in pathophysiology and pathogenesis related to spinal cord lesions and injury.

OriginalsprogEngelsk
Artikelnummer2050
TidsskriftInternational Journal of Molecular Sciences
Vol/bind17
Udgave nummer12
Antal sider18
ISSN1661-6596
DOI
StatusUdgivet - 2016

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