Associations of plasma CD36 and body fat distribution

Yeli Wang, Manja Koch, Romina di Giuseppe, Kirsten Evans, Jan Borggrefe, Ute Nöthlings, Aase Handberg, Majken K Jensen, Wolfgang Lieb

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

CONTEXT: CD36 is a class B scavenger-receptor involved in the uptake of fatty acids in liver and adipose tissue. It is unknown whether plasma CD36 levels are related to liver fat content or adipose tissue in the general population.

METHODS: We measured plasma CD36 from 575 participants of the community-based PopGen-cohort who underwent magnetic resonance imaging (MRI) to quantify visceral (VAT) and subcutaneous (SAT) adipose tissue and liver signal intensity (LSI), a proxy for liver fat content. Non-alcoholic fatty liver disease (NAFLD) was defined as LSI ≥3.0 in the absence of high alcohol intake. The relations between plasma CD36 and body mass index (BMI), VAT, SAT, LSI, and NAFLD were evaluated using multivariable-adjusted linear and logistic regression analysis.

RESULTS: Plasma CD36 concentrations were correlated with BMI (r=0.11; P=0.01), SAT (r=0.16; P<0.001), and VAT (r=0.15, P<0.001), but not with LSI (P=0.44). In multivariable-adjusted regression models, mean BMI values rose across CD36-quartiles (Q1: 27.8 kg/m2; Q4: 28.9 kg/m2; P-trend=0.013). Similarly, VAT (Q1: 4.13 dm3; Q4: 4.71 dm3; P-trend<0.001) and SAT (Q1: 7.61 dm3; Q4: 8.74 dm3; P-trend<0.001) rose across CD36 quartiles. Plasma CD36 concentrations were unrelated to LSI (P-trend=0.36), and NAFLD (P-trend=0.64). Participants with NAFLD and elevated alanine aminotransferase (ALT), a marker for liver damage, had higher CD36 compared to NAFLD participants with normal ALT.

CONCLUSIONS: Higher plasma concentrations of CD36 were associated with greater general and abdominal adiposity, but not with liver fat content or NAFLD in this community-based sample. However, plasma CD36 may reflect more severe liver damage in NAFLD.

OriginalsprogEngelsk
TidsskriftJournal of Clinical Endocrinology and Metabolism
ISSN0021-972X
DOI
StatusE-pub ahead of print - 29 apr. 2019

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Body Fat Distribution
Liver
Fats
Plasmas
Body Mass Index
Alanine Transaminase
Adipose Tissue
Class B Scavenger Receptors
Tissue
Subcutaneous Fat
Adiposity
Proxy
Non-alcoholic Fatty Liver Disease
Linear Models
Fatty Acids
Logistic Models
Regression Analysis
Alcohols
Magnetic Resonance Imaging

Citer dette

Wang, Y., Koch, M., di Giuseppe, R., Evans, K., Borggrefe, J., Nöthlings, U., ... Lieb, W. (2019). Associations of plasma CD36 and body fat distribution. Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/jc.2019-00368
Wang, Yeli ; Koch, Manja ; di Giuseppe, Romina ; Evans, Kirsten ; Borggrefe, Jan ; Nöthlings, Ute ; Handberg, Aase ; Jensen, Majken K ; Lieb, Wolfgang. / Associations of plasma CD36 and body fat distribution. I: Journal of Clinical Endocrinology and Metabolism. 2019.
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title = "Associations of plasma CD36 and body fat distribution",
abstract = "CONTEXT: CD36 is a class B scavenger-receptor involved in the uptake of fatty acids in liver and adipose tissue. It is unknown whether plasma CD36 levels are related to liver fat content or adipose tissue in the general population.METHODS: We measured plasma CD36 from 575 participants of the community-based PopGen-cohort who underwent magnetic resonance imaging (MRI) to quantify visceral (VAT) and subcutaneous (SAT) adipose tissue and liver signal intensity (LSI), a proxy for liver fat content. Non-alcoholic fatty liver disease (NAFLD) was defined as LSI ≥3.0 in the absence of high alcohol intake. The relations between plasma CD36 and body mass index (BMI), VAT, SAT, LSI, and NAFLD were evaluated using multivariable-adjusted linear and logistic regression analysis.RESULTS: Plasma CD36 concentrations were correlated with BMI (r=0.11; P=0.01), SAT (r=0.16; P<0.001), and VAT (r=0.15, P<0.001), but not with LSI (P=0.44). In multivariable-adjusted regression models, mean BMI values rose across CD36-quartiles (Q1: 27.8 kg/m2; Q4: 28.9 kg/m2; P-trend=0.013). Similarly, VAT (Q1: 4.13 dm3; Q4: 4.71 dm3; P-trend<0.001) and SAT (Q1: 7.61 dm3; Q4: 8.74 dm3; P-trend<0.001) rose across CD36 quartiles. Plasma CD36 concentrations were unrelated to LSI (P-trend=0.36), and NAFLD (P-trend=0.64). Participants with NAFLD and elevated alanine aminotransferase (ALT), a marker for liver damage, had higher CD36 compared to NAFLD participants with normal ALT.CONCLUSIONS: Higher plasma concentrations of CD36 were associated with greater general and abdominal adiposity, but not with liver fat content or NAFLD in this community-based sample. However, plasma CD36 may reflect more severe liver damage in NAFLD.",
author = "Yeli Wang and Manja Koch and {di Giuseppe}, Romina and Kirsten Evans and Jan Borggrefe and Ute N{\"o}thlings and Aase Handberg and Jensen, {Majken K} and Wolfgang Lieb",
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Wang, Y, Koch, M, di Giuseppe, R, Evans, K, Borggrefe, J, Nöthlings, U, Handberg, A, Jensen, MK & Lieb, W 2019, 'Associations of plasma CD36 and body fat distribution', Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/jc.2019-00368

Associations of plasma CD36 and body fat distribution. / Wang, Yeli; Koch, Manja; di Giuseppe, Romina; Evans, Kirsten; Borggrefe, Jan; Nöthlings, Ute; Handberg, Aase; Jensen, Majken K; Lieb, Wolfgang.

I: Journal of Clinical Endocrinology and Metabolism, 29.04.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Associations of plasma CD36 and body fat distribution

AU - Wang, Yeli

AU - Koch, Manja

AU - di Giuseppe, Romina

AU - Evans, Kirsten

AU - Borggrefe, Jan

AU - Nöthlings, Ute

AU - Handberg, Aase

AU - Jensen, Majken K

AU - Lieb, Wolfgang

PY - 2019/4/29

Y1 - 2019/4/29

N2 - CONTEXT: CD36 is a class B scavenger-receptor involved in the uptake of fatty acids in liver and adipose tissue. It is unknown whether plasma CD36 levels are related to liver fat content or adipose tissue in the general population.METHODS: We measured plasma CD36 from 575 participants of the community-based PopGen-cohort who underwent magnetic resonance imaging (MRI) to quantify visceral (VAT) and subcutaneous (SAT) adipose tissue and liver signal intensity (LSI), a proxy for liver fat content. Non-alcoholic fatty liver disease (NAFLD) was defined as LSI ≥3.0 in the absence of high alcohol intake. The relations between plasma CD36 and body mass index (BMI), VAT, SAT, LSI, and NAFLD were evaluated using multivariable-adjusted linear and logistic regression analysis.RESULTS: Plasma CD36 concentrations were correlated with BMI (r=0.11; P=0.01), SAT (r=0.16; P<0.001), and VAT (r=0.15, P<0.001), but not with LSI (P=0.44). In multivariable-adjusted regression models, mean BMI values rose across CD36-quartiles (Q1: 27.8 kg/m2; Q4: 28.9 kg/m2; P-trend=0.013). Similarly, VAT (Q1: 4.13 dm3; Q4: 4.71 dm3; P-trend<0.001) and SAT (Q1: 7.61 dm3; Q4: 8.74 dm3; P-trend<0.001) rose across CD36 quartiles. Plasma CD36 concentrations were unrelated to LSI (P-trend=0.36), and NAFLD (P-trend=0.64). Participants with NAFLD and elevated alanine aminotransferase (ALT), a marker for liver damage, had higher CD36 compared to NAFLD participants with normal ALT.CONCLUSIONS: Higher plasma concentrations of CD36 were associated with greater general and abdominal adiposity, but not with liver fat content or NAFLD in this community-based sample. However, plasma CD36 may reflect more severe liver damage in NAFLD.

AB - CONTEXT: CD36 is a class B scavenger-receptor involved in the uptake of fatty acids in liver and adipose tissue. It is unknown whether plasma CD36 levels are related to liver fat content or adipose tissue in the general population.METHODS: We measured plasma CD36 from 575 participants of the community-based PopGen-cohort who underwent magnetic resonance imaging (MRI) to quantify visceral (VAT) and subcutaneous (SAT) adipose tissue and liver signal intensity (LSI), a proxy for liver fat content. Non-alcoholic fatty liver disease (NAFLD) was defined as LSI ≥3.0 in the absence of high alcohol intake. The relations between plasma CD36 and body mass index (BMI), VAT, SAT, LSI, and NAFLD were evaluated using multivariable-adjusted linear and logistic regression analysis.RESULTS: Plasma CD36 concentrations were correlated with BMI (r=0.11; P=0.01), SAT (r=0.16; P<0.001), and VAT (r=0.15, P<0.001), but not with LSI (P=0.44). In multivariable-adjusted regression models, mean BMI values rose across CD36-quartiles (Q1: 27.8 kg/m2; Q4: 28.9 kg/m2; P-trend=0.013). Similarly, VAT (Q1: 4.13 dm3; Q4: 4.71 dm3; P-trend<0.001) and SAT (Q1: 7.61 dm3; Q4: 8.74 dm3; P-trend<0.001) rose across CD36 quartiles. Plasma CD36 concentrations were unrelated to LSI (P-trend=0.36), and NAFLD (P-trend=0.64). Participants with NAFLD and elevated alanine aminotransferase (ALT), a marker for liver damage, had higher CD36 compared to NAFLD participants with normal ALT.CONCLUSIONS: Higher plasma concentrations of CD36 were associated with greater general and abdominal adiposity, but not with liver fat content or NAFLD in this community-based sample. However, plasma CD36 may reflect more severe liver damage in NAFLD.

U2 - 10.1210/jc.2019-00368

DO - 10.1210/jc.2019-00368

M3 - Journal article

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

ER -