The team’s initial hypothesis states that the Mereon Matrix’s First Principles constitute a unitive template generally applicable as an information model. For verification of this premise, the knowledge domain of human molecular genetics was used in a study called ATCG. The Matrix’s seven functions and its fractal principle were applied using the latest (at the point of writing, i.e. up to the beginning of the year 2013) original scientific literature as the source of domain information. ATCG was elaborated through all seven functions with each further explored through its level of micro-functions. The Mereon Matrix was extremely useful in modelling as it constantly forced authors to pose specific questions with respect to the topics inherent at different micro-functions. This allowed searching for answers in the literature using an iterative and incremental modelling process. Upon completing the project it was concluded that the Mereon Matrix as a template for modelling human molecular genetics met and exceeded what was anticipated.