Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Clinical Microbiology and Infection |
| Vol/bind | 17 |
| Sider (fra-til) | 627-32 |
| Antal sider | 6 |
| ISSN | 1198-743X |
| DOI | |
| Status | Udgivet - 2011 |
| Udgivet eksternt | Ja |
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I: Clinical Microbiology and Infection, Bind 17, 2011, s. 627-32.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Baseline C-reactive protein level as a predictor of mortality in bacteraemia patients: a population-based cohort study
AU - Gradel, Kim O
AU - Thomsen, Reimar W
AU - Lundbye-Christensen, Søren
AU - Nielsen, Henrik
AU - Schønheyder, Henrik C
PY - 2011
Y1 - 2011
N2 - ABSTRACT We examined the association between CRP level at time of blood culture (BC) draw and mortality following bacteraemia. Our population-based cohort study comprised all first-time mono-microbial bacteraemia episodes in adults in a Danish county during 1996-2004 (n = 5,267). CRP was measured 24 h within the first positive BC draw. Cox's regression was used to compute mortality rate ratios (MRR) associated with CRP level quartiles (10-64 [reference], 65-143, 144-240, and 241-688 mg/L), controlling for age, gender, comorbidity, specialty, acquisition of infection, and infection focus. We also investigated for a biological interaction between CRP level and high magnitude of bacteraemia (3 of 3 culture bottles positive). 30-day mortality increased with higher CRP level: adjusted 0-30 day MRR for patients in the 2nd, 3rd, and 4th CRP quartile were 1.38 (95% confidence intervals, 1.13-1.69), 1.70 (1.40-2.06), and 2.38 (1.96-2.87), respectively (P for trend <10(-4)). In contrast, mortality associations with CRP during 31-365 days' follow-up were weak (adjusted MRR for 2nd-4th quartile ranged from 1.18 to 1.28). A high magnitude of bacteraemia strengthened the association between high CRP level and 30-day mortality. We conclude that the CRP level, measured concurrently with the first positive BC, independently predicted 30-day mortality in adult bacteraemia patients.
AB - ABSTRACT We examined the association between CRP level at time of blood culture (BC) draw and mortality following bacteraemia. Our population-based cohort study comprised all first-time mono-microbial bacteraemia episodes in adults in a Danish county during 1996-2004 (n = 5,267). CRP was measured 24 h within the first positive BC draw. Cox's regression was used to compute mortality rate ratios (MRR) associated with CRP level quartiles (10-64 [reference], 65-143, 144-240, and 241-688 mg/L), controlling for age, gender, comorbidity, specialty, acquisition of infection, and infection focus. We also investigated for a biological interaction between CRP level and high magnitude of bacteraemia (3 of 3 culture bottles positive). 30-day mortality increased with higher CRP level: adjusted 0-30 day MRR for patients in the 2nd, 3rd, and 4th CRP quartile were 1.38 (95% confidence intervals, 1.13-1.69), 1.70 (1.40-2.06), and 2.38 (1.96-2.87), respectively (P for trend <10(-4)). In contrast, mortality associations with CRP during 31-365 days' follow-up were weak (adjusted MRR for 2nd-4th quartile ranged from 1.18 to 1.28). A high magnitude of bacteraemia strengthened the association between high CRP level and 30-day mortality. We conclude that the CRP level, measured concurrently with the first positive BC, independently predicted 30-day mortality in adult bacteraemia patients.
U2 - 10.1111/j.1469-0691.2010.03284.x
DO - 10.1111/j.1469-0691.2010.03284.x
M3 - Journal article
SN - 1198-743X
VL - 17
SP - 627
EP - 632
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
ER -