TY - JOUR
T1 - Behandlingsniveau og behandlingsstop ved benign lungesygdom
AU - Rath Sørensen, Anita
AU - Brendstrup, Elisabeth
AU - Titlestad, Ingrid Louise
AU - Stæhr Jensen, Jens Ulrik
AU - Hohwu Thomsen, Laura
AU - Roberts, Nassim Bazeghi
AU - Gjørup, Pia Holland
AU - Shaker, Saher
AU - Gundestrup, Svend
AU - Wilcke, Torgny Rostrup
AU - Weinreich, Ulla Møller
AU - Marså, Kristoffer
N1 - Publiceret i Ugeskrift for Læger 2019, Årgang 181, nummer 13, side 1236-1239
PY - 2018
Y1 - 2018
N2 - Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.
AB - Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.
M3 - Tidsskriftartikel
SN - 0041-5782
VL - 180
SP - 2
EP - 6
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
M1 - V04180270
ER -