Behavioral Responses and Starvation Survival of Daphnia magna exposed to Fluoxetine and Propranolol

Majken Elley Nielsen, Peter Roslev

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

3 Citationer (Scopus)

Resumé

Fluoxetine and propranolol are neuroactive human pharmaceuticals that occur frequently as pollutants in surface waters. The potential effects of these pharmaceuticals on aquatic organisms have raised concern but many adverse effects are not well characterized for a broad range of concentrations and endpoints. In this study, 6 biological parameters in the freshwater Cladoceran Daphnia magna were compared for their responses to fluoxetine or propranolol exposure: mobility (dichotomous response), active swimming time, swimming distance, swimming velocity, swimming acceleration speed, and survival in the absence of food (starvation-survival). Changes in swimming behavior was quantified by video tracking followed by image analyses at six exposure concentrations between 100 ng/L and 10 mg/L. Active swimming time and swimming distance were the most responsive parameters among the behavioral traits. Sublethal exposure concentrations resulted in nonmonotonic responses and behavior profiling suggested that fluoxetine and propranolol stimulated swimming activity at 1–10 μg/L whereas lower (0.1–1 μg/L) and higher exposure concentrations (>100 μg/L) inhibited swimming activity. The ability to survive in the absence of food when exposed to fluoxetine or propranolol resulted in EC50 and EC10 values that were lower than for swimming behavior (EC50 of 0.79–0.99 mg/L; EC10 of 1.4–2.9 μg/L). Starvation-survival appeared to be a potentially simple and sensitive endpoint for adverse effects in D. magna at intermediate exposure concentrations. Nonmonotonic behavioral responses at low exposure concentrations and decreased ability to survive starvation should be considered in assessment of adverse effects of pharmaceuticals to freshwater invertebrates.

OriginalsprogEngelsk
TidsskriftChemosphere
Vol/bind211
Sider (fra-til)978-985
Antal sider8
ISSN0045-6535
DOI
StatusUdgivet - nov. 2018

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behavioral response
starvation
swimming behavior
drug
food
aquatic organism
exposure
invertebrate
surface water
effect
pollutant

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title = "Behavioral Responses and Starvation Survival of Daphnia magna exposed to Fluoxetine and Propranolol",
abstract = "Fluoxetine and propranolol are neuroactive human pharmaceuticals that occur frequently as pollutants in surface waters. The potential effects of these pharmaceuticals on aquatic organisms have raised concern but many adverse effects are not well characterized for a broad range of concentrations and endpoints. In this study, 6 biological parameters in the freshwater Cladoceran Daphnia magna were compared for their responses to fluoxetine or propranolol exposure: mobility (dichotomous response), active swimming time, swimming distance, swimming velocity, swimming acceleration speed, and survival in the absence of food (starvation-survival). Changes in swimming behavior was quantified by video tracking followed by image analyses at six exposure concentrations between 100 ng/L and 10 mg/L. Active swimming time and swimming distance were the most responsive parameters among the behavioral traits. Sublethal exposure concentrations resulted in nonmonotonic responses and behavior profiling suggested that fluoxetine and propranolol stimulated swimming activity at 1–10 μg/L whereas lower (0.1–1 μg/L) and higher exposure concentrations (>100 μg/L) inhibited swimming activity. The ability to survive in the absence of food when exposed to fluoxetine or propranolol resulted in EC50 and EC10 values that were lower than for swimming behavior (EC50 of 0.79–0.99 mg/L; EC10 of 1.4–2.9 μg/L). Starvation-survival appeared to be a potentially simple and sensitive endpoint for adverse effects in D. magna at intermediate exposure concentrations. Nonmonotonic behavioral responses at low exposure concentrations and decreased ability to survive starvation should be considered in assessment of adverse effects of pharmaceuticals to freshwater invertebrates.",
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Behavioral Responses and Starvation Survival of Daphnia magna exposed to Fluoxetine and Propranolol. / Nielsen, Majken Elley; Roslev, Peter.

I: Chemosphere, Bind 211, 11.2018, s. 978-985.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Behavioral Responses and Starvation Survival of Daphnia magna exposed to Fluoxetine and Propranolol

AU - Nielsen, Majken Elley

AU - Roslev, Peter

PY - 2018/11

Y1 - 2018/11

N2 - Fluoxetine and propranolol are neuroactive human pharmaceuticals that occur frequently as pollutants in surface waters. The potential effects of these pharmaceuticals on aquatic organisms have raised concern but many adverse effects are not well characterized for a broad range of concentrations and endpoints. In this study, 6 biological parameters in the freshwater Cladoceran Daphnia magna were compared for their responses to fluoxetine or propranolol exposure: mobility (dichotomous response), active swimming time, swimming distance, swimming velocity, swimming acceleration speed, and survival in the absence of food (starvation-survival). Changes in swimming behavior was quantified by video tracking followed by image analyses at six exposure concentrations between 100 ng/L and 10 mg/L. Active swimming time and swimming distance were the most responsive parameters among the behavioral traits. Sublethal exposure concentrations resulted in nonmonotonic responses and behavior profiling suggested that fluoxetine and propranolol stimulated swimming activity at 1–10 μg/L whereas lower (0.1–1 μg/L) and higher exposure concentrations (>100 μg/L) inhibited swimming activity. The ability to survive in the absence of food when exposed to fluoxetine or propranolol resulted in EC50 and EC10 values that were lower than for swimming behavior (EC50 of 0.79–0.99 mg/L; EC10 of 1.4–2.9 μg/L). Starvation-survival appeared to be a potentially simple and sensitive endpoint for adverse effects in D. magna at intermediate exposure concentrations. Nonmonotonic behavioral responses at low exposure concentrations and decreased ability to survive starvation should be considered in assessment of adverse effects of pharmaceuticals to freshwater invertebrates.

AB - Fluoxetine and propranolol are neuroactive human pharmaceuticals that occur frequently as pollutants in surface waters. The potential effects of these pharmaceuticals on aquatic organisms have raised concern but many adverse effects are not well characterized for a broad range of concentrations and endpoints. In this study, 6 biological parameters in the freshwater Cladoceran Daphnia magna were compared for their responses to fluoxetine or propranolol exposure: mobility (dichotomous response), active swimming time, swimming distance, swimming velocity, swimming acceleration speed, and survival in the absence of food (starvation-survival). Changes in swimming behavior was quantified by video tracking followed by image analyses at six exposure concentrations between 100 ng/L and 10 mg/L. Active swimming time and swimming distance were the most responsive parameters among the behavioral traits. Sublethal exposure concentrations resulted in nonmonotonic responses and behavior profiling suggested that fluoxetine and propranolol stimulated swimming activity at 1–10 μg/L whereas lower (0.1–1 μg/L) and higher exposure concentrations (>100 μg/L) inhibited swimming activity. The ability to survive in the absence of food when exposed to fluoxetine or propranolol resulted in EC50 and EC10 values that were lower than for swimming behavior (EC50 of 0.79–0.99 mg/L; EC10 of 1.4–2.9 μg/L). Starvation-survival appeared to be a potentially simple and sensitive endpoint for adverse effects in D. magna at intermediate exposure concentrations. Nonmonotonic behavioral responses at low exposure concentrations and decreased ability to survive starvation should be considered in assessment of adverse effects of pharmaceuticals to freshwater invertebrates.

KW - Behavior

KW - Daphnia magna

KW - Fluoxetine

KW - Hormesis

KW - Propranolol

KW - Starvation-survival

UR - http://www.scopus.com/inward/record.url?scp=85053188064&partnerID=8YFLogxK

U2 - 10.1016/j.chemosphere.2018.08.027

DO - 10.1016/j.chemosphere.2018.08.027

M3 - Journal article

VL - 211

SP - 978

EP - 985

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

ER -