Abstract
Originalsprog | Engelsk |
---|---|
Tidsskrift | Scandinavian Journal of Urology |
Vol/bind | 43 |
Sider (fra-til) | 442-4 |
Antal sider | 3 |
ISSN | 0036-5599 |
DOI | |
Status | Udgivet - 2009 |
Udgivet eksternt | Ja |
Adgang til dokumentet
Citationsformater
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
I: Scandinavian Journal of Urology, Bind 43, 2009, s. 442-4.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Bisphosphonate (zoledronic acid)-induced osteonecrosis of the jaw
AU - Haidar, Ali
AU - Jønler, Morten
AU - Folkmar, Troels B
AU - Lund, Lars
PY - 2009
Y1 - 2009
N2 - OBJECTIVE: The use of bisphosphonates (zoledronic acid) in the treatment of metastatic bone disease has been raised during recent years. The purpose of this treatment is mainly to reduce skeletal-related events, e.g. pain and pathological fractures. The aim of this study was to report the incidence of bisphosphonate-related osteonecrosis of the jaw (ONJ). MATERIAL AND METHODS: All patients treated with bisphosphonates during a 5-year period (2003-2007) were reviewed. RESULTS: Fifty-three patients, median age 69 years (range 56-81 years) were treated with bisphosphonates during the period. Fifty-one patients had hormone-refractory metastatic prostate cancer and two women had metastatic renal cell carcinoma. During this 5-year period, 686 treatments with bisphosphonates were administrated. The average treatment duration was 14 months (range 1-40 months) with administration of 4 mg of bisphosphonates every 4 weeks. Two cases of ONJ were registered. In the first case, the patient developed spontaneous osteonecrosis, whereas the second patient developed symptoms after a dental procedure. Since the initiation of a routine maxillofacial examination before treatment with bisphosphonates, no ONJ has been seen. CONCLUSION: ONJ is a rare but a very serious complication in relation to treatment with bisphosphonates. To decrease the incidence of ONJ, a maxillofacial examination could be performed in all patients before treatment with bisphosphonates.
AB - OBJECTIVE: The use of bisphosphonates (zoledronic acid) in the treatment of metastatic bone disease has been raised during recent years. The purpose of this treatment is mainly to reduce skeletal-related events, e.g. pain and pathological fractures. The aim of this study was to report the incidence of bisphosphonate-related osteonecrosis of the jaw (ONJ). MATERIAL AND METHODS: All patients treated with bisphosphonates during a 5-year period (2003-2007) were reviewed. RESULTS: Fifty-three patients, median age 69 years (range 56-81 years) were treated with bisphosphonates during the period. Fifty-one patients had hormone-refractory metastatic prostate cancer and two women had metastatic renal cell carcinoma. During this 5-year period, 686 treatments with bisphosphonates were administrated. The average treatment duration was 14 months (range 1-40 months) with administration of 4 mg of bisphosphonates every 4 weeks. Two cases of ONJ were registered. In the first case, the patient developed spontaneous osteonecrosis, whereas the second patient developed symptoms after a dental procedure. Since the initiation of a routine maxillofacial examination before treatment with bisphosphonates, no ONJ has been seen. CONCLUSION: ONJ is a rare but a very serious complication in relation to treatment with bisphosphonates. To decrease the incidence of ONJ, a maxillofacial examination could be performed in all patients before treatment with bisphosphonates.
KW - Aged
KW - Aged, 80 and over
KW - Bone Density Conservation Agents
KW - Bone Neoplasms
KW - Carcinoma, Renal Cell
KW - Diphosphonates
KW - Facial Bones
KW - Female
KW - Humans
KW - Incidence
KW - Jaw Diseases
KW - Kidney Neoplasms
KW - Male
KW - Maxilla
KW - Middle Aged
KW - Osteonecrosis
KW - Prostatic Neoplasms
KW - Retrospective Studies
U2 - 10.3109/00365590903295193
DO - 10.3109/00365590903295193
M3 - Journal article
SN - 0036-5599
VL - 43
SP - 442
EP - 444
JO - Scandinavian Journal of Urology
JF - Scandinavian Journal of Urology
ER -