TY - JOUR
T1 - BODIPY-based nanoparticles for highly efficient photothermal/gas synergistic therapy against drug-resistant bacterial infection
AU - Song, Shuang
AU - Yang, Na
AU - Nawaz, Muhammad Azhar Hayat
AU - He, Di
AU - Han, Wenzhao
AU - Sun, Baosheng
AU - Steinmann, Casper
AU - Qi, Hong
AU - Li, Ying
AU - Shen, Xiande
AU - Yu, Cong
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/11
Y1 - 2024/11
N2 - Drug-resistant bacterial wound infections have become a major threat to human health worldwide, and there is an urgent need to develop a new generation of antibacterial agents to replace conventional antibiotics. In this work, we proposed an efficient nanoplatform that combines photothermal therapy (PTT) and light-triggered release of nitric oxide (NO) to combat bacteria. A multifunctional nanoplatform (BBDH NPs) based on a BODIPY probe, NO thermal responsive donor [N, N′-di-sec-butyl-N, N′-diniroso-1,4-phenylenediamine (BNN6)], and a PEGylated polymer was prepared with a nanoprecipitation method. BBDH NPs represent a one-two punch against bacterial infections, combining potent photothermal therapy and the controlled release of NO, enabling rapid and efficient eradication of gram-negative and gram-positive bacteria. Histological analysis on a mouse model demonstrates that wounds treated with BBDH NPs and 685 nm laser irradiation have completed re-epithelialization, significant collagen deposition, and a number of hair follicle formation. BBDH NPs also exhibit a remarkable therapeutic effect on wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). These results highlight that the proposed synergistic antibacterial strategy can be used as a potential therapeutic tool in drug-resistant, bacterial-infected wounds. Graphical Abstract: (Figure presented.)
AB - Drug-resistant bacterial wound infections have become a major threat to human health worldwide, and there is an urgent need to develop a new generation of antibacterial agents to replace conventional antibiotics. In this work, we proposed an efficient nanoplatform that combines photothermal therapy (PTT) and light-triggered release of nitric oxide (NO) to combat bacteria. A multifunctional nanoplatform (BBDH NPs) based on a BODIPY probe, NO thermal responsive donor [N, N′-di-sec-butyl-N, N′-diniroso-1,4-phenylenediamine (BNN6)], and a PEGylated polymer was prepared with a nanoprecipitation method. BBDH NPs represent a one-two punch against bacterial infections, combining potent photothermal therapy and the controlled release of NO, enabling rapid and efficient eradication of gram-negative and gram-positive bacteria. Histological analysis on a mouse model demonstrates that wounds treated with BBDH NPs and 685 nm laser irradiation have completed re-epithelialization, significant collagen deposition, and a number of hair follicle formation. BBDH NPs also exhibit a remarkable therapeutic effect on wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). These results highlight that the proposed synergistic antibacterial strategy can be used as a potential therapeutic tool in drug-resistant, bacterial-infected wounds. Graphical Abstract: (Figure presented.)
UR - http://www.scopus.com/inward/record.url?scp=85207172071&partnerID=8YFLogxK
U2 - 10.1007/s10853-024-10351-x
DO - 10.1007/s10853-024-10351-x
M3 - Journal article
AN - SCOPUS:85207172071
SN - 0022-2461
VL - 59
SP - 19628
EP - 19641
JO - Journal of Materials Science
JF - Journal of Materials Science
IS - 41
ER -