BODIPY-based nanoparticles for highly efficient photothermal/gas synergistic therapy against drug-resistant bacterial infection

Shuang Song, Na Yang, Muhammad Azhar Hayat Nawaz, Di He, Wenzhao Han, Baosheng Sun, Casper Steinmann, Hong Qi*, Ying Li*, Xiande Shen*, Cong Yu*

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1 Citationer (Scopus)

Abstract

Drug-resistant bacterial wound infections have become a major threat to human health worldwide, and there is an urgent need to develop a new generation of antibacterial agents to replace conventional antibiotics. In this work, we proposed an efficient nanoplatform that combines photothermal therapy (PTT) and light-triggered release of nitric oxide (NO) to combat bacteria. A multifunctional nanoplatform (BBDH NPs) based on a BODIPY probe, NO thermal responsive donor [N, N′-di-sec-butyl-N, N′-diniroso-1,4-phenylenediamine (BNN6)], and a PEGylated polymer was prepared with a nanoprecipitation method. BBDH NPs represent a one-two punch against bacterial infections, combining potent photothermal therapy and the controlled release of NO, enabling rapid and efficient eradication of gram-negative and gram-positive bacteria. Histological analysis on a mouse model demonstrates that wounds treated with BBDH NPs and 685 nm laser irradiation have completed re-epithelialization, significant collagen deposition, and a number of hair follicle formation. BBDH NPs also exhibit a remarkable therapeutic effect on wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). These results highlight that the proposed synergistic antibacterial strategy can be used as a potential therapeutic tool in drug-resistant, bacterial-infected wounds. Graphical Abstract: (Figure presented.)

OriginalsprogEngelsk
TidsskriftJournal of Materials Science
Vol/bind59
Udgave nummer41
Sider (fra-til)19628-19641
Antal sider14
ISSN0022-2461
DOI
StatusUdgivet - nov. 2024

Bibliografisk note

Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

Fingeraftryk

Dyk ned i forskningsemnerne om 'BODIPY-based nanoparticles for highly efficient photothermal/gas synergistic therapy against drug-resistant bacterial infection'. Sammen danner de et unikt fingeraftryk.

Citationsformater