Abstract The aim was to investigate the association between building-related
symptoms (BRS) in office buildings and the inflammatory potency of dust (PD).
Furthermore, the association between dust potency and various building characteristics
was investigated. Occupants of 22 office buildings received a retrospective
questionnaire about BRS (2301 respondents). Dust was collected from
groups of offices and building characteristics were recorded. The potency of a
dust sample to induce interleukin-8 (IL-8) secretion from the lung epithelial cell
line A549 was measured as the slope of the initial linear part of the concentration-
response curve. Symptoms of the central nervous system (CNS) were
associated with the potency of surface dust (OR ¼ 1.4). This association may be
due to an association between an index of CNS symptoms and dust potency in
offices of 1-6 occupants (OR ¼ 1.5). No single symptoms correlated with the
potency of surface dust. The PD was not related to single building factors. The
inflammatory PD may be used as an integrated proxy measure of biologically
active compounds in dust, reflecting health relevant properties of the dust.
|Status||Udgivet - 2007|