Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Mev Dominguez-Valentin, Julian R Sampson, Toni T Seppälä, Sanne W Ten Broeke, John-Paul Plazzer, Sigve Nakken, Christoph Engel, Stefan Aretz, Mark A Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Huw Thomas, D Gareth Evans, John Burn, Marc Greenblatt, Eivind Hovig, Wouter H de Vos Tot Nederveen Cappel, Rolf H SijmonsLucio Bertario, Maria Grazia Tibiletti, Giulia Martina Cavestro, Annika Lindblom, Adriana Della Valle, Francisco Lopez-Köstner, Nathan Gluck, Lior H Katz, Karl Heinimann, Carlos A Vaccaro, Reinhard Büttner, Heike Görgens, Elke Holinski-Feder, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Hans K Schackert, Verena Steinke-Lange, Wolff Schmiegel, Deepak Vangala, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, John L Hopper, Aung Ko Win, Robert W Haile, Noralane M Lindor, Steven Gallinger, Loïc Le Marchand, Polly A Newcomb, Jane C Figueiredo, Stephen N Thibodeau, Karin Wadt, Christina Therkildsen, Henrik Okkels, Zohreh Ketabi, Leticia Moreira, Ariadna Sánchez, Miquel Serra-Burriel, Marta Pineda, Matilde Navarro, Ignacio Blanco, Kate Green, Fiona Lalloo, Emma J Crosbie, James Hill, Oliver G Denton, Ian M Frayling, Einar Andreas Rødland, Hans Vasen, Miriam Mints, Florencia Neffa, Patricia Esperon, Karin Alvarez, Revital Kariv, Guy Rosner, Tamara Alejandra Pinero, María Laura Gonzalez, Pablo Kalfayan, Douglas Tjandra, Ingrid M Winship, Finlay Macrae, Gabriela Möslein, Jukka-Pekka Mecklin, Maartje Nielsen, Pål Møller

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1 Citation (Scopus)
OriginalsprogEngelsk
TidsskriftGenetics in Medicine
ISSN1098-3600
DOI
StatusE-pub ahead of print - 24 jul. 2019

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Hereditary Nonpolyposis Colorectal Neoplasms
DNA Mismatch Repair
Neoplasm Genes
Databases
Endometrial Neoplasms
Neoplasms
Ovarian Neoplasms
Colorectal Neoplasms
Urologic Neoplasms
Upper Gastrointestinal Tract
Penetrance
Colonic Neoplasms
Genes
Observational Studies
Prostate
Prospective Studies
Guidelines
Brain

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Dominguez-Valentin, Mev ; Sampson, Julian R ; Seppälä, Toni T ; Ten Broeke, Sanne W ; Plazzer, John-Paul ; Nakken, Sigve ; Engel, Christoph ; Aretz, Stefan ; Jenkins, Mark A ; Sunde, Lone ; Bernstein, Inge ; Capella, Gabriel ; Balaguer, Francesc ; Thomas, Huw ; Evans, D Gareth ; Burn, John ; Greenblatt, Marc ; Hovig, Eivind ; de Vos Tot Nederveen Cappel, Wouter H ; Sijmons, Rolf H ; Bertario, Lucio ; Tibiletti, Maria Grazia ; Cavestro, Giulia Martina ; Lindblom, Annika ; Della Valle, Adriana ; Lopez-Köstner, Francisco ; Gluck, Nathan ; Katz, Lior H ; Heinimann, Karl ; Vaccaro, Carlos A ; Büttner, Reinhard ; Görgens, Heike ; Holinski-Feder, Elke ; Morak, Monika ; Holzapfel, Stefanie ; Hüneburg, Robert ; Knebel Doeberitz, Magnus von ; Loeffler, Markus ; Rahner, Nils ; Schackert, Hans K ; Steinke-Lange, Verena ; Schmiegel, Wolff ; Vangala, Deepak ; Pylvänäinen, Kirsi ; Renkonen-Sinisalo, Laura ; Hopper, John L ; Win, Aung Ko ; Haile, Robert W ; Lindor, Noralane M ; Gallinger, Steven ; Le Marchand, Loïc ; Newcomb, Polly A ; Figueiredo, Jane C ; Thibodeau, Stephen N ; Wadt, Karin ; Therkildsen, Christina ; Okkels, Henrik ; Ketabi, Zohreh ; Moreira, Leticia ; Sánchez, Ariadna ; Serra-Burriel, Miquel ; Pineda, Marta ; Navarro, Matilde ; Blanco, Ignacio ; Green, Kate ; Lalloo, Fiona ; Crosbie, Emma J ; Hill, James ; Denton, Oliver G ; Frayling, Ian M ; Rødland, Einar Andreas ; Vasen, Hans ; Mints, Miriam ; Neffa, Florencia ; Esperon, Patricia ; Alvarez, Karin ; Kariv, Revital ; Rosner, Guy ; Pinero, Tamara Alejandra ; Gonzalez, María Laura ; Kalfayan, Pablo ; Tjandra, Douglas ; Winship, Ingrid M ; Macrae, Finlay ; Möslein, Gabriela ; Mecklin, Jukka-Pekka ; Nielsen, Maartje ; Møller, Pål. / Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants : findings from the Prospective Lynch Syndrome Database. I: Genetics in Medicine. 2019.
@article{a8e9194dded24769be9d0858672d57a1,
title = "Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database",
author = "Mev Dominguez-Valentin and Sampson, {Julian R} and Sepp{\"a}l{\"a}, {Toni T} and {Ten Broeke}, {Sanne W} and John-Paul Plazzer and Sigve Nakken and Christoph Engel and Stefan Aretz and Jenkins, {Mark A} and Lone Sunde and Inge Bernstein and Gabriel Capella and Francesc Balaguer and Huw Thomas and Evans, {D Gareth} and John Burn and Marc Greenblatt and Eivind Hovig and {de Vos Tot Nederveen Cappel}, {Wouter H} and Sijmons, {Rolf H} and Lucio Bertario and Tibiletti, {Maria Grazia} and Cavestro, {Giulia Martina} and Annika Lindblom and {Della Valle}, Adriana and Francisco Lopez-K{\"o}stner and Nathan Gluck and Katz, {Lior H} and Karl Heinimann and Vaccaro, {Carlos A} and Reinhard B{\"u}ttner and Heike G{\"o}rgens and Elke Holinski-Feder and Monika Morak and Stefanie Holzapfel and Robert H{\"u}neburg and {Knebel Doeberitz}, {Magnus von} and Markus Loeffler and Nils Rahner and Schackert, {Hans K} and Verena Steinke-Lange and Wolff Schmiegel and Deepak Vangala and Kirsi Pylv{\"a}n{\"a}inen and Laura Renkonen-Sinisalo and Hopper, {John L} and Win, {Aung Ko} and Haile, {Robert W} and Lindor, {Noralane M} and Steven Gallinger and {Le Marchand}, Lo{\"i}c and Newcomb, {Polly A} and Figueiredo, {Jane C} and Thibodeau, {Stephen N} and Karin Wadt and Christina Therkildsen and Henrik Okkels and Zohreh Ketabi and Leticia Moreira and Ariadna S{\'a}nchez and Miquel Serra-Burriel and Marta Pineda and Matilde Navarro and Ignacio Blanco and Kate Green and Fiona Lalloo and Crosbie, {Emma J} and James Hill and Denton, {Oliver G} and Frayling, {Ian M} and R{\o}dland, {Einar Andreas} and Hans Vasen and Miriam Mints and Florencia Neffa and Patricia Esperon and Karin Alvarez and Revital Kariv and Guy Rosner and Pinero, {Tamara Alejandra} and Gonzalez, {Mar{\'i}a Laura} and Pablo Kalfayan and Douglas Tjandra and Winship, {Ingrid M} and Finlay Macrae and Gabriela M{\"o}slein and Jukka-Pekka Mecklin and Maartje Nielsen and P{\aa}l M{\o}ller",
year = "2019",
month = "7",
day = "24",
doi = "10.1038/s41436-019-0596-9",
language = "English",
journal = "Genetics in Medicine",
issn = "1098-3600",
publisher = "Nature Publishing Group",

}

Dominguez-Valentin, M, Sampson, JR, Seppälä, TT, Ten Broeke, SW, Plazzer, J-P, Nakken, S, Engel, C, Aretz, S, Jenkins, MA, Sunde, L, Bernstein, I, Capella, G, Balaguer, F, Thomas, H, Evans, DG, Burn, J, Greenblatt, M, Hovig, E, de Vos Tot Nederveen Cappel, WH, Sijmons, RH, Bertario, L, Tibiletti, MG, Cavestro, GM, Lindblom, A, Della Valle, A, Lopez-Köstner, F, Gluck, N, Katz, LH, Heinimann, K, Vaccaro, CA, Büttner, R, Görgens, H, Holinski-Feder, E, Morak, M, Holzapfel, S, Hüneburg, R, Knebel Doeberitz, MV, Loeffler, M, Rahner, N, Schackert, HK, Steinke-Lange, V, Schmiegel, W, Vangala, D, Pylvänäinen, K, Renkonen-Sinisalo, L, Hopper, JL, Win, AK, Haile, RW, Lindor, NM, Gallinger, S, Le Marchand, L, Newcomb, PA, Figueiredo, JC, Thibodeau, SN, Wadt, K, Therkildsen, C, Okkels, H, Ketabi, Z, Moreira, L, Sánchez, A, Serra-Burriel, M, Pineda, M, Navarro, M, Blanco, I, Green, K, Lalloo, F, Crosbie, EJ, Hill, J, Denton, OG, Frayling, IM, Rødland, EA, Vasen, H, Mints, M, Neffa, F, Esperon, P, Alvarez, K, Kariv, R, Rosner, G, Pinero, TA, Gonzalez, ML, Kalfayan, P, Tjandra, D, Winship, IM, Macrae, F, Möslein, G, Mecklin, J-P, Nielsen, M & Møller, P 2019, 'Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database', Genetics in Medicine. https://doi.org/10.1038/s41436-019-0596-9

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants : findings from the Prospective Lynch Syndrome Database. / Dominguez-Valentin, Mev; Sampson, Julian R; Seppälä, Toni T; Ten Broeke, Sanne W; Plazzer, John-Paul; Nakken, Sigve; Engel, Christoph; Aretz, Stefan; Jenkins, Mark A; Sunde, Lone; Bernstein, Inge; Capella, Gabriel; Balaguer, Francesc; Thomas, Huw; Evans, D Gareth; Burn, John; Greenblatt, Marc; Hovig, Eivind; de Vos Tot Nederveen Cappel, Wouter H; Sijmons, Rolf H; Bertario, Lucio; Tibiletti, Maria Grazia; Cavestro, Giulia Martina; Lindblom, Annika; Della Valle, Adriana; Lopez-Köstner, Francisco; Gluck, Nathan; Katz, Lior H; Heinimann, Karl; Vaccaro, Carlos A; Büttner, Reinhard; Görgens, Heike; Holinski-Feder, Elke; Morak, Monika; Holzapfel, Stefanie; Hüneburg, Robert; Knebel Doeberitz, Magnus von; Loeffler, Markus; Rahner, Nils; Schackert, Hans K; Steinke-Lange, Verena; Schmiegel, Wolff; Vangala, Deepak; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Hopper, John L; Win, Aung Ko; Haile, Robert W; Lindor, Noralane M; Gallinger, Steven; Le Marchand, Loïc; Newcomb, Polly A; Figueiredo, Jane C; Thibodeau, Stephen N; Wadt, Karin; Therkildsen, Christina; Okkels, Henrik; Ketabi, Zohreh; Moreira, Leticia; Sánchez, Ariadna; Serra-Burriel, Miquel; Pineda, Marta; Navarro, Matilde; Blanco, Ignacio; Green, Kate; Lalloo, Fiona; Crosbie, Emma J; Hill, James; Denton, Oliver G; Frayling, Ian M; Rødland, Einar Andreas; Vasen, Hans; Mints, Miriam; Neffa, Florencia; Esperon, Patricia; Alvarez, Karin; Kariv, Revital; Rosner, Guy; Pinero, Tamara Alejandra; Gonzalez, María Laura; Kalfayan, Pablo; Tjandra, Douglas; Winship, Ingrid M; Macrae, Finlay; Möslein, Gabriela; Mecklin, Jukka-Pekka; Nielsen, Maartje; Møller, Pål.

I: Genetics in Medicine, 24.07.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants

T2 - findings from the Prospective Lynch Syndrome Database

AU - Dominguez-Valentin, Mev

AU - Sampson, Julian R

AU - Seppälä, Toni T

AU - Ten Broeke, Sanne W

AU - Plazzer, John-Paul

AU - Nakken, Sigve

AU - Engel, Christoph

AU - Aretz, Stefan

AU - Jenkins, Mark A

AU - Sunde, Lone

AU - Bernstein, Inge

AU - Capella, Gabriel

AU - Balaguer, Francesc

AU - Thomas, Huw

AU - Evans, D Gareth

AU - Burn, John

AU - Greenblatt, Marc

AU - Hovig, Eivind

AU - de Vos Tot Nederveen Cappel, Wouter H

AU - Sijmons, Rolf H

AU - Bertario, Lucio

AU - Tibiletti, Maria Grazia

AU - Cavestro, Giulia Martina

AU - Lindblom, Annika

AU - Della Valle, Adriana

AU - Lopez-Köstner, Francisco

AU - Gluck, Nathan

AU - Katz, Lior H

AU - Heinimann, Karl

AU - Vaccaro, Carlos A

AU - Büttner, Reinhard

AU - Görgens, Heike

AU - Holinski-Feder, Elke

AU - Morak, Monika

AU - Holzapfel, Stefanie

AU - Hüneburg, Robert

AU - Knebel Doeberitz, Magnus von

AU - Loeffler, Markus

AU - Rahner, Nils

AU - Schackert, Hans K

AU - Steinke-Lange, Verena

AU - Schmiegel, Wolff

AU - Vangala, Deepak

AU - Pylvänäinen, Kirsi

AU - Renkonen-Sinisalo, Laura

AU - Hopper, John L

AU - Win, Aung Ko

AU - Haile, Robert W

AU - Lindor, Noralane M

AU - Gallinger, Steven

AU - Le Marchand, Loïc

AU - Newcomb, Polly A

AU - Figueiredo, Jane C

AU - Thibodeau, Stephen N

AU - Wadt, Karin

AU - Therkildsen, Christina

AU - Okkels, Henrik

AU - Ketabi, Zohreh

AU - Moreira, Leticia

AU - Sánchez, Ariadna

AU - Serra-Burriel, Miquel

AU - Pineda, Marta

AU - Navarro, Matilde

AU - Blanco, Ignacio

AU - Green, Kate

AU - Lalloo, Fiona

AU - Crosbie, Emma J

AU - Hill, James

AU - Denton, Oliver G

AU - Frayling, Ian M

AU - Rødland, Einar Andreas

AU - Vasen, Hans

AU - Mints, Miriam

AU - Neffa, Florencia

AU - Esperon, Patricia

AU - Alvarez, Karin

AU - Kariv, Revital

AU - Rosner, Guy

AU - Pinero, Tamara Alejandra

AU - Gonzalez, María Laura

AU - Kalfayan, Pablo

AU - Tjandra, Douglas

AU - Winship, Ingrid M

AU - Macrae, Finlay

AU - Möslein, Gabriela

AU - Mecklin, Jukka-Pekka

AU - Nielsen, Maartje

AU - Møller, Pål

PY - 2019/7/24

Y1 - 2019/7/24

U2 - 10.1038/s41436-019-0596-9

DO - 10.1038/s41436-019-0596-9

M3 - Journal article

JO - Genetics in Medicine

JF - Genetics in Medicine

SN - 1098-3600

ER -