Resumé

BACKGROUND AND PURPOSE: Defining margins around the Gross Tumour Volume (GTV) to create a Clinical Target Volume (CTV) for head and neck cancer radiotherapy has traditionally been based on presumed knowledge of anatomical routes of spread. However, using a concentric geometric expansion around the GTV may be more reproducible. The purpose of this study was to analyse the inter-observer consistency of geometric CTV delineation with adaptation for anatomical boundaries versus anatomically defined CTVs.

MATERIAL AND METHODS: Radiation oncologists at four Danish cancer centres delineated high, intermediate and elective dose CTVs (CTV1, CTV2 and CTV3, respectively) in a patient-case template (stage IV squamous cell carcinoma of the oropharynx), first using mainly anatomical margins (original standard) and then using concentric geometric expansion (new standard). Each centre made a dummy-run radiotherapy plan based on the delineated CTVs. The difference between the CTV contours and the radiotherapy plans was evaluated across the centres.

RESULTS: Anatomy-based contours were significantly more heterogenous and showed larger volume differences between centres than geometric margins. Dice similarity coefficient increased by 0.29 and mean surface distance decreased by 4mm for CTV1. Use of consistent CTV volumes resulted in more consistent irradiated volumes between centres.

CONCLUSION: Introduction of geometric margins resulted in more uniform CTV1 and CTV2 delineation. Geometric CTV expansion was easier, left less room for misinterpretation, and resulted in more uniform treatment plans with similar irradiated high and intermediate dose volumes across all centres.

OriginalsprogEngelsk
TitelDanske Kræftforskningsdage : Abstract Book
Publikationsdato2018
Sider98
Artikelnummer#90
StatusUdgivet - 2018
BegivenhedDanske Kræftforskningsdage 2018 - Odeon Konferencecenter, Odense, Danmark
Varighed: 30 aug. 201831 aug. 2018
http://www.dccc.dk/danske-kraeftforskningsdage/danske-kraftforskningsdage-2018/

Konference

KonferenceDanske Kræftforskningsdage 2018
LokationOdeon Konferencecenter
LandDanmark
ByOdense
Periode30/08/201831/08/2018
Internetadresse

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Adenocarcinoma
Radiotherapy
Biomarkers
Tumor Burden
DNA
Oropharynx
Head and Neck Neoplasms
Squamous Cell Carcinoma
Anatomy
Neoplasms
Therapeutics
Radiation Oncologists

Citer dette

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abstract = "BACKGROUND AND PURPOSE: Defining margins around the Gross Tumour Volume (GTV) to create a Clinical Target Volume (CTV) for head and neck cancer radiotherapy has traditionally been based on presumed knowledge of anatomical routes of spread. However, using a concentric geometric expansion around the GTV may be more reproducible. The purpose of this study was to analyse the inter-observer consistency of geometric CTV delineation with adaptation for anatomical boundaries versus anatomically defined CTVs.MATERIAL AND METHODS: Radiation oncologists at four Danish cancer centres delineated high, intermediate and elective dose CTVs (CTV1, CTV2 and CTV3, respectively) in a patient-case template (stage IV squamous cell carcinoma of the oropharynx), first using mainly anatomical margins (original standard) and then using concentric geometric expansion (new standard). Each centre made a dummy-run radiotherapy plan based on the delineated CTVs. The difference between the CTV contours and the radiotherapy plans was evaluated across the centres.RESULTS: Anatomy-based contours were significantly more heterogenous and showed larger volume differences between centres than geometric margins. Dice similarity coefficient increased by 0.29 and mean surface distance decreased by 4mm for CTV1. Use of consistent CTV volumes resulted in more consistent irradiated volumes between centres.CONCLUSION: Introduction of geometric margins resulted in more uniform CTV1 and CTV2 delineation. Geometric CTV expansion was easier, left less room for misinterpretation, and resulted in more uniform treatment plans with similar irradiated high and intermediate dose volumes across all centres.",
keywords = "Journal Article",
author = "Henriksen, {Stine Dam} and Madsen, {Poul Henning} and Larsen, {Anders Christian} and {Berg Johansen}, Martin and Asbj{\o}rn Drewes and Pedersen, {Inge S{\o}kilde} and Henrik Krarup and Ole Thorlacius-Ussing",
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Henriksen, SD, Madsen, PH, Larsen, AC, Berg Johansen, M, Drewes, A, Pedersen, IS, Krarup, H & Thorlacius-Ussing, O 2018, Cell-free DNA promoter hypermethylation in plasma as biomarkers for pancreatic adenocarcinoma. i Danske Kræftforskningsdage: Abstract Book., #90, s. 98, Danske Kræftforskningsdage 2018, Odense, Danmark, 30/08/2018.

Cell-free DNA promoter hypermethylation in plasma as biomarkers for pancreatic adenocarcinoma. / Henriksen, Stine Dam; Madsen, Poul Henning; Larsen, Anders Christian; Berg Johansen, Martin; Drewes, Asbjørn; Pedersen, Inge Søkilde; Krarup, Henrik; Thorlacius-Ussing, Ole.

Danske Kræftforskningsdage: Abstract Book. 2018. s. 98 #90.

Publikation: Bidrag til bog/antologi/rapport/konference proceedingKonferenceabstrakt i proceedingForskningpeer review

TY - ABST

T1 - Cell-free DNA promoter hypermethylation in plasma as biomarkers for pancreatic adenocarcinoma

AU - Henriksen, Stine Dam

AU - Madsen, Poul Henning

AU - Larsen, Anders Christian

AU - Berg Johansen, Martin

AU - Drewes, Asbjørn

AU - Pedersen, Inge Søkilde

AU - Krarup, Henrik

AU - Thorlacius-Ussing, Ole

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2018

Y1 - 2018

N2 - BACKGROUND AND PURPOSE: Defining margins around the Gross Tumour Volume (GTV) to create a Clinical Target Volume (CTV) for head and neck cancer radiotherapy has traditionally been based on presumed knowledge of anatomical routes of spread. However, using a concentric geometric expansion around the GTV may be more reproducible. The purpose of this study was to analyse the inter-observer consistency of geometric CTV delineation with adaptation for anatomical boundaries versus anatomically defined CTVs.MATERIAL AND METHODS: Radiation oncologists at four Danish cancer centres delineated high, intermediate and elective dose CTVs (CTV1, CTV2 and CTV3, respectively) in a patient-case template (stage IV squamous cell carcinoma of the oropharynx), first using mainly anatomical margins (original standard) and then using concentric geometric expansion (new standard). Each centre made a dummy-run radiotherapy plan based on the delineated CTVs. The difference between the CTV contours and the radiotherapy plans was evaluated across the centres.RESULTS: Anatomy-based contours were significantly more heterogenous and showed larger volume differences between centres than geometric margins. Dice similarity coefficient increased by 0.29 and mean surface distance decreased by 4mm for CTV1. Use of consistent CTV volumes resulted in more consistent irradiated volumes between centres.CONCLUSION: Introduction of geometric margins resulted in more uniform CTV1 and CTV2 delineation. Geometric CTV expansion was easier, left less room for misinterpretation, and resulted in more uniform treatment plans with similar irradiated high and intermediate dose volumes across all centres.

AB - BACKGROUND AND PURPOSE: Defining margins around the Gross Tumour Volume (GTV) to create a Clinical Target Volume (CTV) for head and neck cancer radiotherapy has traditionally been based on presumed knowledge of anatomical routes of spread. However, using a concentric geometric expansion around the GTV may be more reproducible. The purpose of this study was to analyse the inter-observer consistency of geometric CTV delineation with adaptation for anatomical boundaries versus anatomically defined CTVs.MATERIAL AND METHODS: Radiation oncologists at four Danish cancer centres delineated high, intermediate and elective dose CTVs (CTV1, CTV2 and CTV3, respectively) in a patient-case template (stage IV squamous cell carcinoma of the oropharynx), first using mainly anatomical margins (original standard) and then using concentric geometric expansion (new standard). Each centre made a dummy-run radiotherapy plan based on the delineated CTVs. The difference between the CTV contours and the radiotherapy plans was evaluated across the centres.RESULTS: Anatomy-based contours were significantly more heterogenous and showed larger volume differences between centres than geometric margins. Dice similarity coefficient increased by 0.29 and mean surface distance decreased by 4mm for CTV1. Use of consistent CTV volumes resulted in more consistent irradiated volumes between centres.CONCLUSION: Introduction of geometric margins resulted in more uniform CTV1 and CTV2 delineation. Geometric CTV expansion was easier, left less room for misinterpretation, and resulted in more uniform treatment plans with similar irradiated high and intermediate dose volumes across all centres.

KW - Journal Article

M3 - Conference abstract in proceeding

SP - 98

BT - Danske Kræftforskningsdage

ER -