TY - JOUR
T1 - Central hypersensitivity in chronic musculoskeletal pain
AU - Curatolo, Michele
AU - Arendt-Nielsen, Lars
PY - 2015
Y1 - 2015
N2 - Clinical research has consistently detected alteration in central pain processing leading to hypersensitivity. Most methods used in humans are reliable and have face validity to detect widespread central hypersensitivity. However, construct validity is difficult to investigate due to lack of gold standards. Reference values in the pain-free population have been generated, but need replication. Research on pain biomarkers that reflect specific central hypersensitivity processes is warranted. Few studies have analyzed the prognostic value of central hypersensitivity. Most medications acting at central level and some non-pharmacological approaches, including psychological interventions, are likely to attenuate central hypersensitivity.
AB - Clinical research has consistently detected alteration in central pain processing leading to hypersensitivity. Most methods used in humans are reliable and have face validity to detect widespread central hypersensitivity. However, construct validity is difficult to investigate due to lack of gold standards. Reference values in the pain-free population have been generated, but need replication. Research on pain biomarkers that reflect specific central hypersensitivity processes is warranted. Few studies have analyzed the prognostic value of central hypersensitivity. Most medications acting at central level and some non-pharmacological approaches, including psychological interventions, are likely to attenuate central hypersensitivity.
KW - Central sensitization
KW - Chronic pain
KW - Hyperalgesia
KW - Quantitative sensory tests
KW - Central sensitization
KW - Chronic pain
KW - Hyperalgesia
KW - Quantitative sensory tests
U2 - 10.1016/j.pmr.2014.12.002
DO - 10.1016/j.pmr.2014.12.002
M3 - Journal article
SN - 1047-9651
VL - 26
SP - 175
EP - 184
JO - Physical Medicine and Rehabilitation Clinics of North America
JF - Physical Medicine and Rehabilitation Clinics of North America
IS - 2
ER -