Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Hakan Erdem; Derya Ozturk-Engin; Yasemin Cag; Seniha Senbayrak; Asuman Inan; Esra Kazak; Nazif Elaldi; Umit Savasci; Haluk Vahaboglu; Rodrigo Hasbun; ID-IRI study group; Signe Maj Sørensen

doi:10.1016/j.ijid.2017.10.011

Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Hakan Erdem, Derya Ozturk-Engin, Yasemin Cag, Seniha Senbayrak, Asuman Inan, Esra Kazak, Nazif Elaldi, Umit Savasci, Haluk Vahaboglu, Rodrigo Hasbun^*, ID-IRI study group, Signe Maj Sørensen (Medlem af forfattergruppering)

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Publikation: Bidrag til tidsskrift › Letter › peer review

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Abstract

Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.

Originalsprog	Engelsk
Tidsskrift	International Journal of Infectious Diseases
Vol/bind	65
Sider (fra-til)	107-109
Antal sider	3
ISSN	1201-9712
DOI	https://doi.org/10.1016/j.ijid.2017.10.011
Status	Udgivet - 1 dec. 2017

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10.1016/j.ijid.2017.10.011Licens: CC BY-NC-ND 4.0

Open Access articleForlagets udgivne version, 276 KBLicens: CC BY-NC-ND 4.0

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title = "Central nervous system infections in the absence of cerebrospinal fluid pleocytosis",

abstract = "Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.",

keywords = "CSF, Encephalitis, Leukocyte, Meningitis, Pleocytosis",

author = "Hakan Erdem and Derya Ozturk-Engin and Yasemin Cag and Seniha Senbayrak and Asuman Inan and Esra Kazak and Nazif Elaldi and Umit Savasci and Haluk Vahaboglu and Rodrigo Hasbun and {ID-IRI study group} and Mihai Nechifor and Hulya Tireli and Gamze Kilicoglu and Sylviane Defres and Serda Gulsun and Nurgul Ceran and Alexandru Crisan and Johansen, {Isik Somuncu} and Mustafa Namiduru and Saim Dayan and Uner Kayabas and Emine Parlak and Ahmad Khalifa and Ebru Kursun and Sipahi, {Oguz Resat} and Mucahit Yemisen and Ayhan Akbulut and Mehmet Bitirgen and Natasa Popovic and Bahar Kandemir and Catalina Luca and Mehmet Parlak and Stahl, {Jean Paul} and Filiz Pehlivanoglu and Soline Simeon and Aysegul Ulu-Kilic and Kadriye Yasar and Gulden Yilmaz and Emel Yilmaz and Bojana Beovic and Melanie Catroux and Botond Lakatos and Mustafa Sunbul and Oral Oncul and Selma Alabay and Elif Sahin-Horasan and Sukran Kose and Ghaydaa Shehata and Lykke Larsen and S{\o}rensen, {Signe Maj}",

year = "2017",

month = dec,

day = "1",

doi = "10.1016/j.ijid.2017.10.011",

language = "English",

volume = "65",

pages = "107--109",

journal = "International Journal of Infectious Diseases",

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T1 - Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

AU - Erdem, Hakan

AU - Ozturk-Engin, Derya

AU - Cag, Yasemin

AU - Senbayrak, Seniha

AU - Inan, Asuman

AU - Kazak, Esra

AU - Elaldi, Nazif

AU - Savasci, Umit

AU - Vahaboglu, Haluk

AU - Hasbun, Rodrigo

AU - ID-IRI study group

A2 - Nechifor, Mihai

A2 - Tireli, Hulya

A2 - Kilicoglu, Gamze

A2 - Defres, Sylviane

A2 - Gulsun, Serda

A2 - Ceran, Nurgul

A2 - Crisan, Alexandru

A2 - Johansen, Isik Somuncu

A2 - Namiduru, Mustafa

A2 - Dayan, Saim

A2 - Kayabas, Uner

A2 - Parlak, Emine

A2 - Khalifa, Ahmad

A2 - Kursun, Ebru

A2 - Sipahi, Oguz Resat

A2 - Yemisen, Mucahit

A2 - Akbulut, Ayhan

A2 - Bitirgen, Mehmet

A2 - Popovic, Natasa

A2 - Kandemir, Bahar

A2 - Luca, Catalina

A2 - Parlak, Mehmet

A2 - Stahl, Jean Paul

A2 - Pehlivanoglu, Filiz

A2 - Simeon, Soline

A2 - Ulu-Kilic, Aysegul

A2 - Yasar, Kadriye

A2 - Yilmaz, Gulden

A2 - Yilmaz, Emel

A2 - Beovic, Bojana

A2 - Catroux, Melanie

A2 - Lakatos, Botond

A2 - Sunbul, Mustafa

A2 - Oncul, Oral

A2 - Alabay, Selma

A2 - Sahin-Horasan, Elif

A2 - Kose, Sukran

A2 - Shehata, Ghaydaa

A2 - Larsen, Lykke

A2 - Sørensen, Signe Maj

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.

AB - Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.

KW - CSF

KW - Encephalitis

KW - Leukocyte

KW - Meningitis

KW - Pleocytosis

UR - http://www.scopus.com/inward/record.url?scp=85033370896&partnerID=8YFLogxK

U2 - 10.1016/j.ijid.2017.10.011

DO - 10.1016/j.ijid.2017.10.011

M3 - Letter

C2 - 29081366

AN - SCOPUS:85033370896

SN - 1201-9712

VL - 65

SP - 107

EP - 109

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Abstract

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