Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans

Anders Olsen; Maithili C Vantipalli; Gordon J Lithgow

doi:10.1126/science.1124981

Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans

Anders Olsen, Maithili C Vantipalli, Gordon J Lithgow

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

58 Citationer (Scopus)

Abstract

Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.

Originalsprog	Engelsk
Tidsskrift	Science
Vol/bind	312
Udgave nummer	5778
Sider (fra-til)	1381-5
Antal sider	5
ISSN	0036-8075
DOI	https://doi.org/10.1126/science.1124981
Status	Udgivet - 2 jun. 2006
Udgivet eksternt	Ja

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10.1126/science.1124981

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abstract = "Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.",

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author = "Anders Olsen and Vantipalli, {Maithili C} and Lithgow, {Gordon J}",

year = "2006",

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AU - Olsen, Anders

AU - Vantipalli, Maithili C

AU - Lithgow, Gordon J

PY - 2006/6/2

Y1 - 2006/6/2

N2 - Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.

AB - Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.

KW - Adaptation, Physiological/genetics

KW - Animals

KW - Caenorhabditis elegans/cytology

KW - Caenorhabditis elegans Proteins/genetics

KW - Cell Cycle Proteins/genetics

KW - Cell Survival

KW - Checkpoint Kinase 1

KW - Heat-Shock Proteins/biosynthesis

KW - Mitosis/genetics

KW - Mutation

KW - Protein Kinases/metabolism

KW - Schizosaccharomyces pombe Proteins

KW - Signal Transduction

KW - Stem Cells/cytology

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DO - 10.1126/science.1124981

M3 - Journal article

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SN - 0036-8075

VL - 312

SP - 1381

EP - 1385

JO - Science

JF - Science

IS - 5778

ER -

Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans

Abstract

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