Abstract
AIM: To determine the splanchnic blood flow and oxygen uptake in healthy-subjects and patients and to relate the findings to body-composition.
METHODS: The total splanchnic blood flow (SBF) and oxygen uptake (SO₂U) were measured in 20 healthy volunteers (10 women) and 29 patients with suspected chronic intestinal ischemia (15 women), age 40-85 years, prior to and after a standard meal. The method is based on the Fick principle using the continuous infusion of an indicator (99mTechnetium-labelled mebrofenin) and catheterization of an artery and the hepatic vein. An angiography of the intestinal arteries was performed during the same investigation. A whole-body dual-energy x-ray absorptiometry scan was performed in healthy volunteers to determine body composition.
RESULTS: Angiography revealed no atherosclerotic lesions in the intestinal arteries. The mean baseline SBF was 1087 mL/min (731-1390), and this value increased significantly to 1787 mL/min after the meal in healthy volunteers (P < 0.001). The baseline SBF in patients was 1080 mL/min, which increased to 1718 mL/min postprandially (P < 0.001). The baseline SBF was independent of age, sex, lean body mass and percentage of body fat. The mean meal-induced increase in SBF was equal to 282 mL/min + 5.4 mL/min × bodyweight, (P = 0.025). The SO₂U in healthy volunteers and patients was 50.7 mL/min and 48.0 mL/min, respectively, and these values increased to 77.5 mL/min and 75 mL/min postprandially, respectively. Both baseline and postprandial SO₂U were directly related to lean body mass. Age and sex exerted no impact on SO₂U.
CONCLUSION: A direct correlation between body weight and the postprandial increase in SBF was observed. The effect of body weight should be considered in the diagnosis of chronic intestinal ischemia.
Originalsprog | Engelsk |
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Tidsskrift | World Journal of Gastroenterology |
Vol/bind | 19 |
Udgave nummer | 6 |
Sider (fra-til) | 882-8 |
Antal sider | 7 |
ISSN | 1007-9327 |
DOI | |
Status | Udgivet - 2013 |
Udgivet eksternt | Ja |
Emneord
- Absorptiometry, Photon
- Adult
- Aged
- Aged, 80 and over
- Body Composition
- Body Weight
- Case-Control Studies
- Female
- Humans
- Imino Acids
- Ischemia
- Linear Models
- Male
- Mesenteric Arteries
- Mesenteric Ischemia
- Mesenteric Vascular Occlusion
- Middle Aged
- Organotechnetium Compounds
- Oxygen Consumption
- Postprandial Period
- Predictive Value of Tests
- Radiopharmaceuticals
- Reference Values
- Regional Blood Flow
- Splanchnic Circulation
- Vascular Diseases