Publikationer pr. år
Publikationer pr. år
Munsoor A Hanifa, Raluca G Maltesen, Bodil S Rasmussen, Katrine B Buggeskov, Hanne B Ravn, Martin Skott, Søren Nielsen, Jørgen Frøkiær, Troels Ring, Reinhard Wimmer
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
BACKGROUND: In our metabolomics studies we have noticed that repeated NMR acquisition on the same sample can result in altered metabolite signal intensities.
AIMS: To investigate the reproducibility of repeated NMR acquisition on selected metabolites in serum and plasma from two large human metabolomics studies.
METHODS: Two peak regions for each metabolite were integrated and changes occurring after reacquisition were correlated.
RESULTS: Integral changes were generally small, but serum citrate signals decreased significantly in some samples.
CONCLUSIONS: Several metabolite integrals were not reproducible in some of the repeated spectra. Following established protocols, randomising analysis order and biomarker validation are important.
Originalsprog | Engelsk |
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Artikelnummer | 7 |
Tidsskrift | Metabolomics |
Vol/bind | 16 |
Udgave nummer | 1 |
Antal sider | 7 |
ISSN | 1573-3882 |
DOI | |
Status | Udgivet - 1 jan. 2020 |
Publikation: Ph.d.-afhandling