Abstract
There is a lack of data regarding treatment and prognosis for the growing group of oldest old patients with lymphoma. Therefore, we studied 2347 patients aged ≥85 years from the Danish and Swedish lymphoma registers 2000–2016 (Denmark) and 2007–2013 (Sweden). Outcome was assessed using relative survival (RS). The 2-year RS overall for patients with aggressive lymphomas was 38% [95% confidence interval (CI) 35–42%], of whom 845 (66%) patients received active treatment (chemotherapy, radiotherapy, immunotherapy, other). For aggressive lymphomas, not receiving active treatment was associated with an inferior 2-year RS of 12% (95% CI 9–17%) compared to 49% (95% CI 45–53%) for patients who received active treatment (excess mortality rate ratio 2·84, 95% CI 2·3–3·5; P < 0·0001). For patients with indolent lymphoma, the 2-year RS was 77% (95% CI 72–82%). Here, 383 (46%) patients received active treatment at diagnosis, but did not have better 2-year RS (75%, 95% CI 67–81%) compared to those who did not receive active treatment (83%, 95% CI 74–89%). We conclude that outcomes for the oldest old patients with lymphoma are encouraging for several subtypes and that active treatment is associated with improved outcome amongst the oldest old patients with aggressive lymphomas, indicating that age itself should not be a contraindication to treatment.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Haematology |
Vol/bind | 192 |
Udgave nummer | 3 |
Sider (fra-til) | 551-559 |
Antal sider | 9 |
ISSN | 0007-1048 |
DOI | |
Status | Udgivet - feb. 2021 |
Bibliografisk note
Funding Information:Tove Wästerlid, Karin E. Smedby and Henrik Frederiksen initiated and designed the study. Tove Wästerlid and Kim Oren Gradel acquired data. Tove Wästerlid, Kim Oren Gradel and Sandra Eloranta did the statistical analysis. All authors interpreted the data, drafted and reviewed the manuscript, and approved the final manuscript. Tove Wästerlid was supported by Region Stockholm (clinical postdoctoral appointment).
Publisher Copyright:
© 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.