Clinical implications of electrocardiographic bundle branch block in primary care

Peter Vibe Rasmussen, Morten Wagner Skov, Jonas Ghouse, Adrian Pietersen, Steen Møller Hansen, Christian Torp-Pedersen, Lars Køber, Stig Haunsø, Morten Salling Olesen, Jesper Hastrup Svendsen, Jacob Melgaard, Claus Graff, Anders Gaardsdal Holst, Jonas Bille Nielsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objectives Electrocardiographic bundle branch block (BBB) is common but the prognostic implications in primary care are unclear. We sought to investigate the relationship between electrocardiographic BBB subtypes and the risk of cardiovascular (CV) outcomes in a primary care population free of major CV disease.Methods Retrospective cohort study of primary care patients referred for electrocardiogram (ECG) recording between 2001 and 2011. Cox regression models were used to estimate hazard ratios (HR) as well as absolute risks of CV outcomes based on various BBB subtypes.Results We included 202 268 individuals with a median follow-up period of 7.8 years (Inter-quartile range [IQR] 4.9textendash10.6). Left bundle branch block (LBBB) was associated with heart failure (HF) in both men (HR 3.96, 95% CI 3.30 to 4.76) and women (HR 2.51, 95% CI 2.15 to 2.94) and with CV death in men (HR 1.80, 95% CI 1.38 to 2.35). Right bundle branch block (RBBB) was associated with pacemaker implantation in both men (HR 3.26, 95% CI 2.74 to 3.89) and women (HR 3.69, 95% CI 2.91 to 4.67), HF in both sexes and weakly associated with CV death in men. Regarding LBBB, we found an increasing hazard of HF with increasing QRS-interval duration (HR 1.25, 95% CI 1.11 to 1.42 per 10 ms increase in men and HR 1.23, 95% CI 1.08 to 1.40 per 10 ms increase in women). Absolute 10-year risk predictions across age-specific and sex-specific subgroups revealed clinically relevant differences between having various BBB subtypes.Conclusions Opportunistic findings of BBB subtypes in primary care patients without major CV disease should be considered warnings of future HF and pacemaker implantation.
OriginalsprogEngelsk
TidsskriftHeart
ISSN1355-6037
DOI
StatusE-pub ahead of print - 25 maj 2019

Citer dette

Rasmussen, Peter Vibe ; Skov, Morten Wagner ; Ghouse, Jonas ; Pietersen, Adrian ; Hansen, Steen Møller ; Torp-Pedersen, Christian ; Køber, Lars ; Haunsø, Stig ; Olesen, Morten Salling ; Svendsen, Jesper Hastrup ; Melgaard, Jacob ; Graff, Claus ; Holst, Anders Gaardsdal ; Nielsen, Jonas Bille. / Clinical implications of electrocardiographic bundle branch block in primary care. I: Heart. 2019.
@article{6de4704abf3f4f4e9c5a46bf7ccce75c,
title = "Clinical implications of electrocardiographic bundle branch block in primary care",
abstract = "Objectives Electrocardiographic bundle branch block (BBB) is common but the prognostic implications in primary care are unclear. We sought to investigate the relationship between electrocardiographic BBB subtypes and the risk of cardiovascular (CV) outcomes in a primary care population free of major CV disease.Methods Retrospective cohort study of primary care patients referred for electrocardiogram (ECG) recording between 2001 and 2011. Cox regression models were used to estimate hazard ratios (HR) as well as absolute risks of CV outcomes based on various BBB subtypes.Results We included 202 268 individuals with a median follow-up period of 7.8 years (Inter-quartile range [IQR] 4.9textendash10.6). Left bundle branch block (LBBB) was associated with heart failure (HF) in both men (HR 3.96, 95{\%} CI 3.30 to 4.76) and women (HR 2.51, 95{\%} CI 2.15 to 2.94) and with CV death in men (HR 1.80, 95{\%} CI 1.38 to 2.35). Right bundle branch block (RBBB) was associated with pacemaker implantation in both men (HR 3.26, 95{\%} CI 2.74 to 3.89) and women (HR 3.69, 95{\%} CI 2.91 to 4.67), HF in both sexes and weakly associated with CV death in men. Regarding LBBB, we found an increasing hazard of HF with increasing QRS-interval duration (HR 1.25, 95{\%} CI 1.11 to 1.42 per 10 ms increase in men and HR 1.23, 95{\%} CI 1.08 to 1.40 per 10 ms increase in women). Absolute 10-year risk predictions across age-specific and sex-specific subgroups revealed clinically relevant differences between having various BBB subtypes.Conclusions Opportunistic findings of BBB subtypes in primary care patients without major CV disease should be considered warnings of future HF and pacemaker implantation.",
author = "Rasmussen, {Peter Vibe} and Skov, {Morten Wagner} and Jonas Ghouse and Adrian Pietersen and Hansen, {Steen M{\o}ller} and Christian Torp-Pedersen and Lars K{\o}ber and Stig Hauns{\o} and Olesen, {Morten Salling} and Svendsen, {Jesper Hastrup} and Jacob Melgaard and Claus Graff and Holst, {Anders Gaardsdal} and Nielsen, {Jonas Bille}",
year = "2019",
month = "5",
day = "25",
doi = "10.1136/heartjnl-2018-314295",
language = "English",
journal = "Heart",
issn = "1355-6037",
publisher = "B M J Group",

}

Rasmussen, PV, Skov, MW, Ghouse, J, Pietersen, A, Hansen, SM, Torp-Pedersen, C, Køber, L, Haunsø, S, Olesen, MS, Svendsen, JH, Melgaard, J, Graff, C, Holst, AG & Nielsen, JB 2019, 'Clinical implications of electrocardiographic bundle branch block in primary care' Heart. https://doi.org/10.1136/heartjnl-2018-314295

Clinical implications of electrocardiographic bundle branch block in primary care. / Rasmussen, Peter Vibe; Skov, Morten Wagner; Ghouse, Jonas; Pietersen, Adrian; Hansen, Steen Møller; Torp-Pedersen, Christian; Køber, Lars; Haunsø, Stig; Olesen, Morten Salling; Svendsen, Jesper Hastrup; Melgaard, Jacob; Graff, Claus; Holst, Anders Gaardsdal; Nielsen, Jonas Bille.

I: Heart, 25.05.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Clinical implications of electrocardiographic bundle branch block in primary care

AU - Rasmussen, Peter Vibe

AU - Skov, Morten Wagner

AU - Ghouse, Jonas

AU - Pietersen, Adrian

AU - Hansen, Steen Møller

AU - Torp-Pedersen, Christian

AU - Køber, Lars

AU - Haunsø, Stig

AU - Olesen, Morten Salling

AU - Svendsen, Jesper Hastrup

AU - Melgaard, Jacob

AU - Graff, Claus

AU - Holst, Anders Gaardsdal

AU - Nielsen, Jonas Bille

PY - 2019/5/25

Y1 - 2019/5/25

N2 - Objectives Electrocardiographic bundle branch block (BBB) is common but the prognostic implications in primary care are unclear. We sought to investigate the relationship between electrocardiographic BBB subtypes and the risk of cardiovascular (CV) outcomes in a primary care population free of major CV disease.Methods Retrospective cohort study of primary care patients referred for electrocardiogram (ECG) recording between 2001 and 2011. Cox regression models were used to estimate hazard ratios (HR) as well as absolute risks of CV outcomes based on various BBB subtypes.Results We included 202 268 individuals with a median follow-up period of 7.8 years (Inter-quartile range [IQR] 4.9textendash10.6). Left bundle branch block (LBBB) was associated with heart failure (HF) in both men (HR 3.96, 95% CI 3.30 to 4.76) and women (HR 2.51, 95% CI 2.15 to 2.94) and with CV death in men (HR 1.80, 95% CI 1.38 to 2.35). Right bundle branch block (RBBB) was associated with pacemaker implantation in both men (HR 3.26, 95% CI 2.74 to 3.89) and women (HR 3.69, 95% CI 2.91 to 4.67), HF in both sexes and weakly associated with CV death in men. Regarding LBBB, we found an increasing hazard of HF with increasing QRS-interval duration (HR 1.25, 95% CI 1.11 to 1.42 per 10 ms increase in men and HR 1.23, 95% CI 1.08 to 1.40 per 10 ms increase in women). Absolute 10-year risk predictions across age-specific and sex-specific subgroups revealed clinically relevant differences between having various BBB subtypes.Conclusions Opportunistic findings of BBB subtypes in primary care patients without major CV disease should be considered warnings of future HF and pacemaker implantation.

AB - Objectives Electrocardiographic bundle branch block (BBB) is common but the prognostic implications in primary care are unclear. We sought to investigate the relationship between electrocardiographic BBB subtypes and the risk of cardiovascular (CV) outcomes in a primary care population free of major CV disease.Methods Retrospective cohort study of primary care patients referred for electrocardiogram (ECG) recording between 2001 and 2011. Cox regression models were used to estimate hazard ratios (HR) as well as absolute risks of CV outcomes based on various BBB subtypes.Results We included 202 268 individuals with a median follow-up period of 7.8 years (Inter-quartile range [IQR] 4.9textendash10.6). Left bundle branch block (LBBB) was associated with heart failure (HF) in both men (HR 3.96, 95% CI 3.30 to 4.76) and women (HR 2.51, 95% CI 2.15 to 2.94) and with CV death in men (HR 1.80, 95% CI 1.38 to 2.35). Right bundle branch block (RBBB) was associated with pacemaker implantation in both men (HR 3.26, 95% CI 2.74 to 3.89) and women (HR 3.69, 95% CI 2.91 to 4.67), HF in both sexes and weakly associated with CV death in men. Regarding LBBB, we found an increasing hazard of HF with increasing QRS-interval duration (HR 1.25, 95% CI 1.11 to 1.42 per 10 ms increase in men and HR 1.23, 95% CI 1.08 to 1.40 per 10 ms increase in women). Absolute 10-year risk predictions across age-specific and sex-specific subgroups revealed clinically relevant differences between having various BBB subtypes.Conclusions Opportunistic findings of BBB subtypes in primary care patients without major CV disease should be considered warnings of future HF and pacemaker implantation.

U2 - 10.1136/heartjnl-2018-314295

DO - 10.1136/heartjnl-2018-314295

M3 - Journal article

JO - Heart

JF - Heart

SN - 1355-6037

ER -