Abstract
Objectives: Research evidence suggests that chronic pouchitis is associated with intestinal dysbiosis. Faecal microbiota transplantation (FMT) has been proposed as a possible treatment. We performed a 6-month prospective, open-label, single-centre cohort pilot-study (NCT03538366) to investigate if FMT could improve clinical outcome and alter gut microbiota in patients with chronic pouchitis.Materials and methods: Nine adult patients with chronic pouchitis were included and allocated to 14 days FMT by enemas from five faecal donors, with a 6-month follow-up. Pouchitis severity was assessed using pouchitis disease activity index (PDAI) before and after FMT. Changes in gut microbiota, and engraftment of donor's microbiota were assessed in faecal samples.Results: All patients were treated with FMT for 14 continuous days. Overall, four of nine patients receiving FMT were in clinical remission at 30-day follow-up, and three patients remained in remission until 6-month follow-up. Clinical symptoms of pouchitis improved significantly between inclusion and 14-day follow-up (p = .02), but there was no improvement in PDAI between inclusion (mean 8.6) and 30-day follow-up (mean 5.2). Treatment with FMT caused a substantial shift in microbiota and increased microbial diversity in six patients, resembling that of the donors, with a high engraftment of specific donor microbiota.Conclusions: Symptomatic benefit in FMT treatment was found for four of nine patients with chronic pouchitis with increased microbial diversity and high engraftment of donor's microbiota. A larger, randomised controlled study is required to fully evaluate the potential role of FMT in treating chronic pouchitis.
Originalsprog | Engelsk |
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Tidsskrift | Scandinavian Journal of Gastroenterology |
Vol/bind | 55 |
Udgave nummer | 4 |
Sider (fra-til) | 421-429 |
Antal sider | 9 |
ISSN | 0036-5521 |
DOI | |
Status | Udgivet - apr. 2020 |
Fingeraftryk
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Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis: a pilot study
Kousgaard, S. J. (Ophavsperson), Michaelsen, T. Y. (Ophavsperson), Nielsen, H. L. (Ophavsperson), Kirk, K. F. (Ophavsperson), Brandt, J. (Ophavsperson), Albertsen, M. (Ophavsperson) & Thorlacius-Ussing, O. (Ophavsperson), Taylor & Francis, 2020
DOI: 10.6084/m9.figshare.12123111, https://tandf.figshare.com/articles/Clinical_results_and_microbiota_changes_after_faecal_microbiota_transplantation_for_chronic_pouchitis_a_pilot_study/12123111
Datasæt
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Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis: a pilot study
Kousgaard, S. J. (Ophavsperson), Michaelsen, T. Y. (Ophavsperson), Nielsen, H. L. (Ophavsperson), Kirk, K. F. (Ophavsperson), Brandt, J. (Ophavsperson), Albertsen, M. (Ophavsperson) & Thorlacius-Ussing, O. (Ophavsperson), Taylor & Francis, 2020
DOI: 10.6084/m9.figshare.12123111.v1, https://tandf.figshare.com/articles/Clinical_results_and_microbiota_changes_after_faecal_microbiota_transplantation_for_chronic_pouchitis_a_pilot_study/12123111/1
Datasæt