Clinical utility of plasma cell-free DNA in patients with pancreatic cancer

I Chen; K L Wind; C Dehlendorff; B S Sørensen; B V Vittrup; A Johansen; P Pfeiffer; J K Bjerregaard; S E Bojesen; S E Nielsen; N H Holländer; M K Yilmaz; L S Rasmussen; N Pallisgaard; J S Johansen; K-L G Spindler

doi:10.1093/annonc/mdy282.098

Clinical utility of plasma cell-free DNA in patients with pancreatic cancer

I Chen, K L Wind, C Dehlendorff, B S Sørensen, B V Vittrup, A Johansen, P Pfeiffer, J K Bjerregaard, S E Bojesen, S E Nielsen, N H Holländer, M K Yilmaz, L S Rasmussen, N Pallisgaard, J S Johansen, K-L G Spindler

Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning › peer review

15 Citationer (Scopus)

Abstract

Background: Reliable biomarkers in patients (pts) with pancreatic cancer (PC) are highly warranted. The aim of this prospective-retrospective biomarker study was to investigate the clinical value of cell-free DNA (cfDNA) in pts with PC.Methods: A total of 377 consecutive pts with histologically confirmed PC and 94 healthy controls were included. Total cfDNA levels were determined by a direct fluorescent assay in EDTA plasma samples obtained before operation (stage I and II) or start of palliative chemotherapy (stage III and IV). Serum CA19-9 (IMMULITE 2000, Siemens), hyaluronic acid (HA) (ELISA, R\amp;D), interleukin-6 (IL-6) (ELISA, R\amp;D) and YKL-40 (ELISA, Quidel) were measured. The main outcome was association of cfDNA with overall survival (OS) for pts with PC. Hazard ratios (HRs) and 95\% confidence intervals (CIs) were estimated by Cox proportional hazards regression.

Originalsprog	Engelsk
Artikelnummer	715P
Tidsskrift	Annals of Oncology
Vol/bind	29
Udgave nummer	suppl_8
Sider (fra-til)	vii241-vii242
Antal sider	2
ISSN	0923-7534
DOI	https://doi.org/10.1093/annonc/mdy282.098
Status	Udgivet - okt. 2018
Begivenhed	ESMO 2018 Congress (European Society for Medical Oncology): Securing access to optimal cancer care - München, Tyskland Varighed: 19 okt. 2018 → 23 okt. 2018 http://www.esmo.org/Conferences/ESMO-2018-Congress

Konference

Konference	ESMO 2018 Congress (European Society for Medical Oncology)
Land/Område	Tyskland
By	München
Periode	19/10/2018 → 23/10/2018
Internetadresse	http://www.esmo.org/Conferences/ESMO-2018-Congress

Adgang til dokumentet

10.1093/annonc/mdy282.098

https://academic.oup.com/annonc/article/29/suppl_8/mdy282.098/5141571

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Citationsformater

Chen, I., Wind, K. L., Dehlendorff, C., Sørensen, B. S., Vittrup, B. V., Johansen, A., Pfeiffer, P., Bjerregaard, J. K., Bojesen, S. E., Nielsen, S. E., Holländer, N. H., Yilmaz, M. K., Rasmussen, L. S., Pallisgaard, N., Johansen, J. S., & Spindler, K-L. G. (2018). Clinical utility of plasma cell-free DNA in patients with pancreatic cancer. Annals of Oncology, 29(suppl_8), vii241-vii242. Artikel 715P. https://doi.org/10.1093/annonc/mdy282.098

@article{223ae55883634d4f9b6d0836044a2717,

title = "Clinical utility of plasma cell-free DNA in patients with pancreatic cancer",

abstract = "Background: Reliable biomarkers in patients (pts) with pancreatic cancer (PC) are highly warranted. The aim of this prospective-retrospective biomarker study was to investigate the clinical value of cell-free DNA (cfDNA) in pts with PC.Methods: A total of 377 consecutive pts with histologically confirmed PC and 94 healthy controls were included. Total cfDNA levels were determined by a direct fluorescent assay in EDTA plasma samples obtained before operation (stage I and II) or start of palliative chemotherapy (stage III and IV). Serum CA19-9 (IMMULITE 2000, Siemens), hyaluronic acid (HA) (ELISA, R\amp;D), interleukin-6 (IL-6) (ELISA, R\amp;D) and YKL-40 (ELISA, Quidel) were measured. The main outcome was association of cfDNA with overall survival (OS) for pts with PC. Hazard ratios (HRs) and 95\% confidence intervals (CIs) were estimated by Cox proportional hazards regression.",

author = "I Chen and Wind, {K L} and C Dehlendorff and S{\o}rensen, {B S} and Vittrup, {B V} and A Johansen and P Pfeiffer and Bjerregaard, {J K} and Bojesen, {S E} and Nielsen, {S E} and Holl{\"a}nder, {N H} and Yilmaz, {M K} and Rasmussen, {L S} and N Pallisgaard and Johansen, {J S} and Spindler, {K-L G}",

year = "2018",

month = oct,

doi = "10.1093/annonc/mdy282.098",

language = "English",

volume = "29",

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journal = "Annals of Oncology",

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Chen, I, Wind, KL, Dehlendorff, C, Sørensen, BS, Vittrup, BV, Johansen, A, Pfeiffer, P, Bjerregaard, JK, Bojesen, SE, Nielsen, SE, Holländer, NH, Yilmaz, MK, Rasmussen, LS, Pallisgaard, N, Johansen, JS & Spindler, K-LG 2018, 'Clinical utility of plasma cell-free DNA in patients with pancreatic cancer', Annals of Oncology, bind 29, nr. suppl_8, 715P, s. vii241-vii242. https://doi.org/10.1093/annonc/mdy282.098

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T1 - Clinical utility of plasma cell-free DNA in patients with pancreatic cancer

AU - Chen, I

AU - Wind, K L

AU - Dehlendorff, C

AU - Sørensen, B S

AU - Vittrup, B V

AU - Johansen, A

AU - Pfeiffer, P

AU - Bjerregaard, J K

AU - Bojesen, S E

AU - Nielsen, S E

AU - Holländer, N H

AU - Yilmaz, M K

AU - Rasmussen, L S

AU - Pallisgaard, N

AU - Johansen, J S

AU - Spindler, K-L G

PY - 2018/10

Y1 - 2018/10

N2 - Background: Reliable biomarkers in patients (pts) with pancreatic cancer (PC) are highly warranted. The aim of this prospective-retrospective biomarker study was to investigate the clinical value of cell-free DNA (cfDNA) in pts with PC.Methods: A total of 377 consecutive pts with histologically confirmed PC and 94 healthy controls were included. Total cfDNA levels were determined by a direct fluorescent assay in EDTA plasma samples obtained before operation (stage I and II) or start of palliative chemotherapy (stage III and IV). Serum CA19-9 (IMMULITE 2000, Siemens), hyaluronic acid (HA) (ELISA, R\amp;D), interleukin-6 (IL-6) (ELISA, R\amp;D) and YKL-40 (ELISA, Quidel) were measured. The main outcome was association of cfDNA with overall survival (OS) for pts with PC. Hazard ratios (HRs) and 95\% confidence intervals (CIs) were estimated by Cox proportional hazards regression.

AB - Background: Reliable biomarkers in patients (pts) with pancreatic cancer (PC) are highly warranted. The aim of this prospective-retrospective biomarker study was to investigate the clinical value of cell-free DNA (cfDNA) in pts with PC.Methods: A total of 377 consecutive pts with histologically confirmed PC and 94 healthy controls were included. Total cfDNA levels were determined by a direct fluorescent assay in EDTA plasma samples obtained before operation (stage I and II) or start of palliative chemotherapy (stage III and IV). Serum CA19-9 (IMMULITE 2000, Siemens), hyaluronic acid (HA) (ELISA, R\amp;D), interleukin-6 (IL-6) (ELISA, R\amp;D) and YKL-40 (ELISA, Quidel) were measured. The main outcome was association of cfDNA with overall survival (OS) for pts with PC. Hazard ratios (HRs) and 95\% confidence intervals (CIs) were estimated by Cox proportional hazards regression.

U2 - 10.1093/annonc/mdy282.098

DO - 10.1093/annonc/mdy282.098

M3 - Conference abstract in journal

SN - 0923-7534

VL - 29

SP - vii241-vii242

JO - Annals of Oncology

JF - Annals of Oncology

IS - suppl_8

M1 - 715P

T2 - ESMO 2018 Congress (European Society for Medical Oncology)

Y2 - 19 October 2018 through 23 October 2018

ER -