Abstract
Background: Collagen is highly expressed in pancreatic cancer (PC) stroma. Collagen accumulation compromises penetration of macromolecules into tumor tissues and is associated with poorer outcome and increased tumor invasion. The aim of this biomarker study was to investigate the clinical utility of serum pro-peptide of type III collagen (PRO-C3) in patients (pts) with PC.Methods: A cohort from the Danish BIOPAC study (ClinicalTrials.gov ID: NCT03311776) including 851 consecutive subjects with histologically confirmed PC, ampullary carcinoma (n = 45), distal biliary tract cancer (n = 32) and benign lesions (n = 88) were enrolled. Serum PRO-C3 was determined by ELISA (Nordic Bioscience, PRO-C3 protocol). The main outcome was survival among pts with PC (male/female: 458/393; age \lt;50 vs. 50-69 vs. ≥70: 41/477/333; ECOG Performance Status (PS) of 0/1/2+: 315/340/110; stage 1 + 2/3/4: 234/142/456; diabetes yes/no: 207/629; smoking yes/no: 508/265; alcohol yes/no: 183/588; body mass index: low/normal/overweight: 62/426/254; Charlson Age-Comorbidity index (CACI) 0/1-2/3+: 34/296/504) in relation to PRO-C3 levels. Serum CA19-9, hyaluronic acid (HA), C-reactive protein (CRP), interleukin-6 (IL-6) and YKL-40 were measured. Hazard ratios (HRs) and 95\% confidence intervals (CIs) were estimated by Cox proportional hazards regression.
Originalsprog | Engelsk |
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Artikelnummer | 752P |
Tidsskrift | Annals of Oncology |
Vol/bind | 29 |
Udgave nummer | Suppl. 8 |
Sider (fra-til) | viii257 |
Antal sider | 1 |
ISSN | 0923-7534 |
DOI | |
Status | Udgivet - okt. 2018 |
Begivenhed | ESMO 2018 Congress (European Society for Medical Oncology): Securing access to optimal cancer care - München, Tyskland Varighed: 19 okt. 2018 → 23 okt. 2018 http://www.esmo.org/Conferences/ESMO-2018-Congress |
Konference
Konference | ESMO 2018 Congress (European Society for Medical Oncology) |
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Land/Område | Tyskland |
By | München |
Periode | 19/10/2018 → 23/10/2018 |
Internetadresse |