Comparison of fatty acid composition of subcutaneous, pericardial and epicardial adipose tissue and atrial tissue in patients with heart disease

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Resumé

OBJECTIVES The content in adipose tissue of marine n-3 polyunsaturated fatty acids (PUFAs) is a marker of long-term fish consumption and data suggest an antiarrhythmic effect of n-3 PUFAs. We investigated the correlation between adipose tissue content of the major n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), from three different adipose tissue compartments [epicardial (EAT), pericardial (PAT) and subcutaneous (SAT)]. Furthermore, we studied the correlation between the content of EPA and DHA in these compartments and in atrial tissue (AT). METHODS We obtained AT from auricles, EAT above the right ventricle, PAT, and SAT below the sternum from 50 patients undergoing cardiac surgery. Samples were frozen at -80°C and the content of n-3 PUFAs determined by gas chromatography with results given in relative weight%. RESULTS EPA and DHA were significantly correlated in EAT, PAT and SAT with high r-values from 0.70 to 0.87. There was a significant correlation between the content of EPA in adipose tissue and in AT from 0.49 to 0.59, with minor/no correlation between contents of DHA in adipose tissue and in AT. Correlations: DHA / EPA SAT PAT EAT AT SAT 1.00 / 1.00 PAT 0.84* / 0.87* 1.00 / 1.00 EAT 0.85* / 0.76* 0.71* / 0.74* 1.00 / 1.00 AT 0.19 / 0.49* 0.36* / 0.58* 0.28 / 0,59* 1.00 / 1.00 * P< 0.05 CONCLUSIONS: The content of EPA and DHA was very similar in EAT, PAT and SAT. There were significant correlations between the content of EPA, but not of DHA, in adipose tissues and in AT. This might be relevant when studying n-3 PUFAs and atrial arrhythmias.
OriginalsprogEngelsk
Publikationsdato29 maj 2016
StatusUdgivet - 29 maj 2016
BegivenhedEAS Congress - Innsbruck, Østrig
Varighed: 29 maj 20161 jun. 2016
Konferencens nummer: 84

Konference

KonferenceEAS Congress
Nummer84
LandØstrig
ByInnsbruck
Periode29/05/201601/06/2016

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Docosahexaenoic Acids
Adipose Tissue
Eicosapentaenoic Acid
Heart Diseases
Fatty Acids
Omega-3 Fatty Acids
Sternum
Gas Chromatography
Thoracic Surgery
Heart Ventricles
Cardiac Arrhythmias
Fishes
Weights and Measures

Citer dette

@conference{47e59dd3e0e84ac09f033e28d9869ee5,
title = "Comparison of fatty acid composition of subcutaneous, pericardial and epicardial adipose tissue and atrial tissue in patients with heart disease",
abstract = "OBJECTIVES The content in adipose tissue of marine n-3 polyunsaturated fatty acids (PUFAs) is a marker of long-term fish consumption and data suggest an antiarrhythmic effect of n-3 PUFAs. We investigated the correlation between adipose tissue content of the major n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), from three different adipose tissue compartments [epicardial (EAT), pericardial (PAT) and subcutaneous (SAT)]. Furthermore, we studied the correlation between the content of EPA and DHA in these compartments and in atrial tissue (AT). METHODS We obtained AT from auricles, EAT above the right ventricle, PAT, and SAT below the sternum from 50 patients undergoing cardiac surgery. Samples were frozen at -80°C and the content of n-3 PUFAs determined by gas chromatography with results given in relative weight{\%}. RESULTS EPA and DHA were significantly correlated in EAT, PAT and SAT with high r-values from 0.70 to 0.87. There was a significant correlation between the content of EPA in adipose tissue and in AT from 0.49 to 0.59, with minor/no correlation between contents of DHA in adipose tissue and in AT. Correlations: DHA / EPA SAT PAT EAT AT SAT 1.00 / 1.00 PAT 0.84* / 0.87* 1.00 / 1.00 EAT 0.85* / 0.76* 0.71* / 0.74* 1.00 / 1.00 AT 0.19 / 0.49* 0.36* / 0.58* 0.28 / 0,59* 1.00 / 1.00 * P< 0.05 CONCLUSIONS: The content of EPA and DHA was very similar in EAT, PAT and SAT. There were significant correlations between the content of EPA, but not of DHA, in adipose tissues and in AT. This might be relevant when studying n-3 PUFAs and atrial arrhythmias.",
author = "Eschen, {Rikke B{\"u}low} and Jiwei Gu and Andreasen, {Jan Jesper} and Annette Andreasen and S{\o}ren Lundbye-Christensen and Schmidt, {Erik Berg}",
year = "2016",
month = "5",
day = "29",
language = "English",
note = "EAS Congress, EAS ; Conference date: 29-05-2016 Through 01-06-2016",

}

Comparison of fatty acid composition of subcutaneous, pericardial and epicardial adipose tissue and atrial tissue in patients with heart disease. / Eschen, Rikke Bülow; Gu, Jiwei; Andreasen, Jan Jesper; Andreasen, Annette; Lundbye-Christensen, Søren; Schmidt, Erik Berg.

2016. Poster session præsenteret på EAS Congress, Innsbruck, Østrig.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

TY - CONF

T1 - Comparison of fatty acid composition of subcutaneous, pericardial and epicardial adipose tissue and atrial tissue in patients with heart disease

AU - Eschen, Rikke Bülow

AU - Gu, Jiwei

AU - Andreasen, Jan Jesper

AU - Andreasen, Annette

AU - Lundbye-Christensen, Søren

AU - Schmidt, Erik Berg

PY - 2016/5/29

Y1 - 2016/5/29

N2 - OBJECTIVES The content in adipose tissue of marine n-3 polyunsaturated fatty acids (PUFAs) is a marker of long-term fish consumption and data suggest an antiarrhythmic effect of n-3 PUFAs. We investigated the correlation between adipose tissue content of the major n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), from three different adipose tissue compartments [epicardial (EAT), pericardial (PAT) and subcutaneous (SAT)]. Furthermore, we studied the correlation between the content of EPA and DHA in these compartments and in atrial tissue (AT). METHODS We obtained AT from auricles, EAT above the right ventricle, PAT, and SAT below the sternum from 50 patients undergoing cardiac surgery. Samples were frozen at -80°C and the content of n-3 PUFAs determined by gas chromatography with results given in relative weight%. RESULTS EPA and DHA were significantly correlated in EAT, PAT and SAT with high r-values from 0.70 to 0.87. There was a significant correlation between the content of EPA in adipose tissue and in AT from 0.49 to 0.59, with minor/no correlation between contents of DHA in adipose tissue and in AT. Correlations: DHA / EPA SAT PAT EAT AT SAT 1.00 / 1.00 PAT 0.84* / 0.87* 1.00 / 1.00 EAT 0.85* / 0.76* 0.71* / 0.74* 1.00 / 1.00 AT 0.19 / 0.49* 0.36* / 0.58* 0.28 / 0,59* 1.00 / 1.00 * P< 0.05 CONCLUSIONS: The content of EPA and DHA was very similar in EAT, PAT and SAT. There were significant correlations between the content of EPA, but not of DHA, in adipose tissues and in AT. This might be relevant when studying n-3 PUFAs and atrial arrhythmias.

AB - OBJECTIVES The content in adipose tissue of marine n-3 polyunsaturated fatty acids (PUFAs) is a marker of long-term fish consumption and data suggest an antiarrhythmic effect of n-3 PUFAs. We investigated the correlation between adipose tissue content of the major n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), from three different adipose tissue compartments [epicardial (EAT), pericardial (PAT) and subcutaneous (SAT)]. Furthermore, we studied the correlation between the content of EPA and DHA in these compartments and in atrial tissue (AT). METHODS We obtained AT from auricles, EAT above the right ventricle, PAT, and SAT below the sternum from 50 patients undergoing cardiac surgery. Samples were frozen at -80°C and the content of n-3 PUFAs determined by gas chromatography with results given in relative weight%. RESULTS EPA and DHA were significantly correlated in EAT, PAT and SAT with high r-values from 0.70 to 0.87. There was a significant correlation between the content of EPA in adipose tissue and in AT from 0.49 to 0.59, with minor/no correlation between contents of DHA in adipose tissue and in AT. Correlations: DHA / EPA SAT PAT EAT AT SAT 1.00 / 1.00 PAT 0.84* / 0.87* 1.00 / 1.00 EAT 0.85* / 0.76* 0.71* / 0.74* 1.00 / 1.00 AT 0.19 / 0.49* 0.36* / 0.58* 0.28 / 0,59* 1.00 / 1.00 * P< 0.05 CONCLUSIONS: The content of EPA and DHA was very similar in EAT, PAT and SAT. There were significant correlations between the content of EPA, but not of DHA, in adipose tissues and in AT. This might be relevant when studying n-3 PUFAs and atrial arrhythmias.

M3 - Poster

ER -