Comparison of simultaneous plasma clearance of 99mTc-DTPA and 51Cr-EDTA: can one tracer replace the other?

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Resumé

Both Tc-99m-DTPA and Cr-51-EDTA are widely used to determine glomerular filtration rate (GFR), but few direct comparative studies exist. The shortage of Cr-51-EDTA makes a direct comparison highly relevant. The aim of the study was to investigate if there is any clinically relevant difference between plasma clearance of Tc-99m-DTPA and Cr-51-EDTA. Patients textgreater= 18 years of age referred for routine GFR measurement by Cr-51-EDTA were prospectively enrolled. The two tracers (10 MBq Tc-99m-DTPA (CaNa3-DTPA) and 2.5 MBq Cr-51-EDTA) were intravenously injected at time zero. A standard 4-sample technique was applied with samples collected at 180, 200, 220 and 240 min, if the estimated GFR (eGFR) was textgreater= 30 mL/min. A comparison of single-sample GFR based on the 200 min sample was also conducted. Fifty-six patients were enrolled in the study. All patients had an estimated GFR textgreater30 mL/min/1.73 m(2). No patients suffered from ascites or significant oedema. The mean Cr-51-EDTA plasma clearance was 82 mL/min (range 16-226). The plasma clearances determined by the two methods were highly correlated (r = 0.993). The plasma clearance was significantly higher when measured by Tc-99m-DTPA than by Cr-51-EDTA (p = 0.01), but the numerical difference was minimal (mean difference 1.4 mL/min; 95% limits of agreement (LOA) -6.6 to 9.4). The difference between the two methods was independent of the level of renal function. Similar results were found for one-sample GFR. No clinically relevant differences were found between the plasma clearance of Tc-99m-DTPA and that of Cr-51-EDTA. Therefore, Tc-99m-DTPA can replace Cr-51-EDTA when needed.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical & Laboratory Investigation
Vol/bind79
Udgave nummer7
Sider (fra-til)463-467
Antal sider5
ISSN0036-5513
DOI
StatusUdgivet - 2019

Citer dette

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title = "Comparison of simultaneous plasma clearance of 99mTc-DTPA and 51Cr-EDTA: can one tracer replace the other?",
abstract = "Both Tc-99m-DTPA and Cr-51-EDTA are widely used to determine glomerular filtration rate (GFR), but few direct comparative studies exist. The shortage of Cr-51-EDTA makes a direct comparison highly relevant. The aim of the study was to investigate if there is any clinically relevant difference between plasma clearance of Tc-99m-DTPA and Cr-51-EDTA. Patients textgreater= 18 years of age referred for routine GFR measurement by Cr-51-EDTA were prospectively enrolled. The two tracers (10 MBq Tc-99m-DTPA (CaNa3-DTPA) and 2.5 MBq Cr-51-EDTA) were intravenously injected at time zero. A standard 4-sample technique was applied with samples collected at 180, 200, 220 and 240 min, if the estimated GFR (eGFR) was textgreater= 30 mL/min. A comparison of single-sample GFR based on the 200 min sample was also conducted. Fifty-six patients were enrolled in the study. All patients had an estimated GFR textgreater30 mL/min/1.73 m(2). No patients suffered from ascites or significant oedema. The mean Cr-51-EDTA plasma clearance was 82 mL/min (range 16-226). The plasma clearances determined by the two methods were highly correlated (r = 0.993). The plasma clearance was significantly higher when measured by Tc-99m-DTPA than by Cr-51-EDTA (p = 0.01), but the numerical difference was minimal (mean difference 1.4 mL/min; 95{\%} limits of agreement (LOA) -6.6 to 9.4). The difference between the two methods was independent of the level of renal function. Similar results were found for one-sample GFR. No clinically relevant differences were found between the plasma clearance of Tc-99m-DTPA and that of Cr-51-EDTA. Therefore, Tc-99m-DTPA can replace Cr-51-EDTA when needed.",
author = "Andersen, {Trine B.} and Lars J{\o}dal and Nielsen, {Nikolaj S} and Petersen, {Lars J.}",
year = "2019",
doi = "10.1080/00365513.2019.1658217",
language = "English",
volume = "79",
pages = "463--467",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "0036-5513",
publisher = "Taylor & Francis",
number = "7",

}

TY - JOUR

T1 - Comparison of simultaneous plasma clearance of 99mTc-DTPA and 51Cr-EDTA

T2 - can one tracer replace the other?

AU - Andersen, Trine B.

AU - Jødal, Lars

AU - Nielsen, Nikolaj S

AU - Petersen, Lars J.

PY - 2019

Y1 - 2019

N2 - Both Tc-99m-DTPA and Cr-51-EDTA are widely used to determine glomerular filtration rate (GFR), but few direct comparative studies exist. The shortage of Cr-51-EDTA makes a direct comparison highly relevant. The aim of the study was to investigate if there is any clinically relevant difference between plasma clearance of Tc-99m-DTPA and Cr-51-EDTA. Patients textgreater= 18 years of age referred for routine GFR measurement by Cr-51-EDTA were prospectively enrolled. The two tracers (10 MBq Tc-99m-DTPA (CaNa3-DTPA) and 2.5 MBq Cr-51-EDTA) were intravenously injected at time zero. A standard 4-sample technique was applied with samples collected at 180, 200, 220 and 240 min, if the estimated GFR (eGFR) was textgreater= 30 mL/min. A comparison of single-sample GFR based on the 200 min sample was also conducted. Fifty-six patients were enrolled in the study. All patients had an estimated GFR textgreater30 mL/min/1.73 m(2). No patients suffered from ascites or significant oedema. The mean Cr-51-EDTA plasma clearance was 82 mL/min (range 16-226). The plasma clearances determined by the two methods were highly correlated (r = 0.993). The plasma clearance was significantly higher when measured by Tc-99m-DTPA than by Cr-51-EDTA (p = 0.01), but the numerical difference was minimal (mean difference 1.4 mL/min; 95% limits of agreement (LOA) -6.6 to 9.4). The difference between the two methods was independent of the level of renal function. Similar results were found for one-sample GFR. No clinically relevant differences were found between the plasma clearance of Tc-99m-DTPA and that of Cr-51-EDTA. Therefore, Tc-99m-DTPA can replace Cr-51-EDTA when needed.

AB - Both Tc-99m-DTPA and Cr-51-EDTA are widely used to determine glomerular filtration rate (GFR), but few direct comparative studies exist. The shortage of Cr-51-EDTA makes a direct comparison highly relevant. The aim of the study was to investigate if there is any clinically relevant difference between plasma clearance of Tc-99m-DTPA and Cr-51-EDTA. Patients textgreater= 18 years of age referred for routine GFR measurement by Cr-51-EDTA were prospectively enrolled. The two tracers (10 MBq Tc-99m-DTPA (CaNa3-DTPA) and 2.5 MBq Cr-51-EDTA) were intravenously injected at time zero. A standard 4-sample technique was applied with samples collected at 180, 200, 220 and 240 min, if the estimated GFR (eGFR) was textgreater= 30 mL/min. A comparison of single-sample GFR based on the 200 min sample was also conducted. Fifty-six patients were enrolled in the study. All patients had an estimated GFR textgreater30 mL/min/1.73 m(2). No patients suffered from ascites or significant oedema. The mean Cr-51-EDTA plasma clearance was 82 mL/min (range 16-226). The plasma clearances determined by the two methods were highly correlated (r = 0.993). The plasma clearance was significantly higher when measured by Tc-99m-DTPA than by Cr-51-EDTA (p = 0.01), but the numerical difference was minimal (mean difference 1.4 mL/min; 95% limits of agreement (LOA) -6.6 to 9.4). The difference between the two methods was independent of the level of renal function. Similar results were found for one-sample GFR. No clinically relevant differences were found between the plasma clearance of Tc-99m-DTPA and that of Cr-51-EDTA. Therefore, Tc-99m-DTPA can replace Cr-51-EDTA when needed.

U2 - 10.1080/00365513.2019.1658217

DO - 10.1080/00365513.2019.1658217

M3 - Journal article

VL - 79

SP - 463

EP - 467

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 0036-5513

IS - 7

ER -