@article{64ef3a4c70a24e54a285253e983c10c4,
title = "Comprehensive phage display viral antibody profiling using VirScan: potential applications in chronic immune-mediated disease",
abstract = "Phage immunoprecipitation sequencing (PhIP-Seq) is a high-throughput platform that uses programmable phage display for serology. VirScan, a specific PhIP-Seq library encoding viral peptides from all known human viruses, enables comprehensive quantification of past viral exposures. We review its use in immune-mediated diseases (IMDs), highlighting its utility in identifying viral exposures in the context of IMD development. Finally, we evaluate its potential for precision medicine by integrating it with other large-scale omics data sets.",
keywords = "Antibodies, Viral/immunology, Cell Surface Display Techniques/methods, Chronic Disease, High-Throughput Nucleotide Sequencing/methods, Humans, Immune System Diseases/immunology, Immunoprecipitation/methods, Peptide Library, Viruses/immunology, phage immunoprecipitation sequencing, viruses, PhIP-Seq, immune-mediated disease, VirScan",
author = "Shrewsbury, {Jed Valentiner} and Vitus, {Evangelin Shaloom} and Koziol, {Adam Leslie} and Anna Nenarokova and Tine Jess and Rahma Elmahdi",
year = "2024",
month = nov,
day = "19",
doi = "10.1128/jvi.01102-24",
language = "English",
volume = "98",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "11",
}