Comprehensive phage display viral antibody profiling using VirScan: potential applications in chronic immune-mediated disease

Jed Valentiner Shrewsbury, Evangelin Shaloom Vitus, Adam Leslie Koziol, Anna Nenarokova, Tine Jess, Rahma Elmahdi

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Phage immunoprecipitation sequencing (PhIP-Seq) is a high-throughput platform that uses programmable phage display for serology. VirScan, a specific PhIP-Seq library encoding viral peptides from all known human viruses, enables comprehensive quantification of past viral exposures. We review its use in immune-mediated diseases (IMDs), highlighting its utility in identifying viral exposures in the context of IMD development. Finally, we evaluate its potential for precision medicine by integrating it with other large-scale omics data sets.

OriginalsprogEngelsk
Artikelnummere01102-24
TidsskriftJournal of Virology
Vol/bind98
Udgave nummer11
Antal sider19
ISSN0022-538X
DOI
StatusUdgivet - 19 nov. 2024

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