TY - JOUR
T1 - Confusion with the definition and diagnostic criteria for acute on chronic pancreatitis: review and recommendations
AU - Bouça-Machado, Tiago
AU - Andrea-Ferreira, Patrícia
AU - Pedersen, Jan Bech
AU - Mortensen, Michael Bau
AU - Novovic, Srdan
AU - Windsor, John A.
AU - Olesen, Søren Schou
AU - Drewes, Asbjørn Mohr
PY - 2022
Y1 - 2022
N2 - OBJECTIVES: Chronic pancreatitis (CP) is a fibroinflammatory disease complicated by episodes of acute inflammation (acute on chronic pancreatitis (ACP)). This entity is common, variably defined and can reflect different pathological mechanisms that requires different interventions. The aim of this study is to conduct a systematic review of how ACP is described, defined and diagnosed in the literature.METHODS: A systematic search was conducted from January 1993 to June 2020. All articles that used a term to describe ACP in adults were reviewed and definitions and diagnostic criteria were sought.RESULTS: After reviewing 2271 abstracts, 848 articles included a term to describe ACP. The most common descriptions were 'acute on/in CP' (374), 'acute exacerbation of CP' (345) and 'flare(-up) of CP' (43). Among the 848 articles, 14 included a pragmatic definition of ACP, and only 2 papers stated diagnostic criteria. These covered both acute inflammation and acute exacerbation of chronic abdominal pain.CONCLUSION: There is no universally accepted term, definition or diagnostic criteria for ACP. A consensus definition is needed to improve quality and comparability of future articles as well as clinical management.
AB - OBJECTIVES: Chronic pancreatitis (CP) is a fibroinflammatory disease complicated by episodes of acute inflammation (acute on chronic pancreatitis (ACP)). This entity is common, variably defined and can reflect different pathological mechanisms that requires different interventions. The aim of this study is to conduct a systematic review of how ACP is described, defined and diagnosed in the literature.METHODS: A systematic search was conducted from January 1993 to June 2020. All articles that used a term to describe ACP in adults were reviewed and definitions and diagnostic criteria were sought.RESULTS: After reviewing 2271 abstracts, 848 articles included a term to describe ACP. The most common descriptions were 'acute on/in CP' (374), 'acute exacerbation of CP' (345) and 'flare(-up) of CP' (43). Among the 848 articles, 14 included a pragmatic definition of ACP, and only 2 papers stated diagnostic criteria. These covered both acute inflammation and acute exacerbation of chronic abdominal pain.CONCLUSION: There is no universally accepted term, definition or diagnostic criteria for ACP. A consensus definition is needed to improve quality and comparability of future articles as well as clinical management.
KW - Acute pancreatitis
KW - chronic pancreatitis
KW - definition
KW - diagnosis
KW - inflammation
KW - pancreas
UR - http://www.scopus.com/inward/record.url?scp=85124347572&partnerID=8YFLogxK
U2 - 10.1080/00365521.2022.2035811
DO - 10.1080/00365521.2022.2035811
M3 - Journal article
C2 - 35119346
SN - 0036-5521
VL - 57
SP - 719
EP - 725
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 6
ER -