Publikationer pr. år
Publikationer pr. år
Jens Vinther Larsen*, Morten Hostrup Martinsen, Martin Bødtker Mortensen, Ib Christian Klausen, Berit Storgaard Hedegaard
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
INTRODUCTION: Numerous studies have shown that lowering of low-density lipoprotein-cholesterol (LDL-C) reduces the risk of cardiovascular disease (CVD). To optimise treatment, some patients are referred to a lipid clinic. The reduction in LDL-C achieved in a lipid clinic in contemporary practice is, however, not well described. The aim of the present study was to assess the LDL-C lowering effect among very high-risk patients with or without statin-associated muscle symptoms (SAMS) after treatment at a specialised lipid clinic endorsing European guidelines. METHODS: Medical records from 653 patients referred to our Lipid Clinic from 1 January 2013 to 1 May 2017 were examined retrospectively. Very high-risk patients were defined as either having CVD or diabetes mellitus Type 2 who were active smokers and/or had hypertension. The reduction in LDL-C and the number of patients reaching the LDL-C treatment target were investigated by comparing baseline data with the most recent values recorded. RESULTS: We identified 208 patients at a very high-risk for CVD. They obtained an LDL-C reduction of 23% corresponding to a reduction in LDL-C of 0.7 mmol/l (p < 0.001). The percentage of patients reaching their LDL-C goal increased from 13% to 32%. In patients who had experienced SAMS, LDL-C was reduced by 26% corresponding to a reduction in LDL-C of 0.9 mmol/l (p < 0.001), and the percentage of patients reaching their LDL-C goal increased from 8% to 23%. CONCLUSIONS: Very high-risk patients with or without SAMS obtained a clinically meaningful reduction in LDL-C of approximately 25% owing to their Lipid Clinic treatment.
Originalsprog | Engelsk |
---|---|
Artikelnummer | A08200610 |
Tidsskrift | Danish Medical Journal |
Vol/bind | 68 |
Udgave nummer | 1 |
Sider (fra-til) | 1-9 |
Antal sider | 9 |
ISSN | 1603-9629 |
Status | Udgivet - 1 jan. 2021 |
Publikation: Ph.d.-afhandling