Content of alpha-linolenic acid in human atrial tissue correlates with plasma levels of alpha-linolenic acid

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Resumé

Background: Marine omega-3 fatty acids have antiarrhythmic effects, but whether the plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) have similar effects is less documented. Some data suggest that intake of ALA may reduce sudden cardiac death (and presumably ventricular arrhythmias) but little is known about a possible effect of ALA on atrial arrhythmias including atrial fibrillation (AF). A possible effect of ALA on AF would probably be caused by incorporation of ALA into atrial tissue.
Aim of study: To compare plasma phospholipid levels of ALA to levels in atrial muscle tissue
Methods: Atrial tissue was obtained from 50 patients during cardiac surgery (valvular surgery and/or coronary artery bypass grafting) and plasma was sampled prior to skin incision. Fatty acid composition was determined in both atrial tissue and plasma phospholipids (49 samples available) by gas chromatography and ALA levels were compared by the Pearson correlation coefficient.
Results: There was a statistical significant correlation (r=0.54, 95% confidence interval: 0.30-0.71) between levels of ALA in plasma phospholipids and atrial tissue.
Conclusion: The content of ALA in plasma phospholipids is a short term indicator of intake of ALA and this correlated well with the content of ALA in atrial tissue. Atrial tissue is not readily available but this study shows that determination of plasma phospholipids may be useful to further investigate an antiarrhythmic effect of ALA on AF.
OriginalsprogEngelsk
Publikationsdato5 sep. 2016
StatusUdgivet - 5 sep. 2016
Begivenhed12th Congress of the International Society for the Study of Fatty Acids and Lipids - Stellenbosch University, Cape Town, Sydafrika
Varighed: 5 sep. 20169 sep. 2016
Konferencens nummer: 12
http://www.issfalcongress.com/

Konference

Konference12th Congress of the International Society for the Study of Fatty Acids and Lipids
Nummer12
LokationStellenbosch University
LandSydafrika
ByCape Town
Periode05/09/201609/09/2016
Internetadresse

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alpha-Linolenic Acid
Phospholipids
Atrial Fibrillation
Omega-3 Fatty Acids
Cardiac Arrhythmias
Sudden Cardiac Death
Coronary Artery Bypass
Gas Chromatography
Thoracic Surgery
Fatty Acids

Citer dette

Gu, J., Eschen, R. B., Andreasen, A., Schmidt, E. B., Andreasen, J. J., & Lundbye-Christensen, S. (2016). Content of alpha-linolenic acid in human atrial tissue correlates with plasma levels of alpha-linolenic acid. Poster præsenteret på 12th Congress of the International Society for the Study of Fatty Acids and Lipids, Cape Town, Sydafrika.
@conference{6b885ab8caad4790a3e645c6f9192505,
title = "Content of alpha-linolenic acid in human atrial tissue correlates with plasma levels of alpha-linolenic acid",
abstract = "Background: Marine omega-3 fatty acids have antiarrhythmic effects, but whether the plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) have similar effects is less documented. Some data suggest that intake of ALA may reduce sudden cardiac death (and presumably ventricular arrhythmias) but little is known about a possible effect of ALA on atrial arrhythmias including atrial fibrillation (AF). A possible effect of ALA on AF would probably be caused by incorporation of ALA into atrial tissue.Aim of study: To compare plasma phospholipid levels of ALA to levels in atrial muscle tissueMethods: Atrial tissue was obtained from 50 patients during cardiac surgery (valvular surgery and/or coronary artery bypass grafting) and plasma was sampled prior to skin incision. Fatty acid composition was determined in both atrial tissue and plasma phospholipids (49 samples available) by gas chromatography and ALA levels were compared by the Pearson correlation coefficient.Results: There was a statistical significant correlation (r=0.54, 95{\%} confidence interval: 0.30-0.71) between levels of ALA in plasma phospholipids and atrial tissue.Conclusion: The content of ALA in plasma phospholipids is a short term indicator of intake of ALA and this correlated well with the content of ALA in atrial tissue. Atrial tissue is not readily available but this study shows that determination of plasma phospholipids may be useful to further investigate an antiarrhythmic effect of ALA on AF.",
author = "Jiwei Gu and Eschen, {Rikke B{\"u}low} and Annette Andreasen and Schmidt, {Erik Berg} and Andreasen, {Jan Jesper} and S{\o}ren Lundbye-Christensen",
note = "Poster nr.. 36; null ; Conference date: 05-09-2016 Through 09-09-2016",
year = "2016",
month = "9",
day = "5",
language = "English",
url = "http://www.issfalcongress.com/",

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Gu, J, Eschen, RB, Andreasen, A, Schmidt, EB, Andreasen, JJ & Lundbye-Christensen, S 2016, 'Content of alpha-linolenic acid in human atrial tissue correlates with plasma levels of alpha-linolenic acid', 12th Congress of the International Society for the Study of Fatty Acids and Lipids, Cape Town, Sydafrika, 05/09/2016 - 09/09/2016.

Content of alpha-linolenic acid in human atrial tissue correlates with plasma levels of alpha-linolenic acid. / Gu, Jiwei; Eschen, Rikke Bülow; Andreasen, Annette; Schmidt, Erik Berg; Andreasen, Jan Jesper; Lundbye-Christensen, Søren.

2016. Poster præsenteret på 12th Congress of the International Society for the Study of Fatty Acids and Lipids, Cape Town, Sydafrika.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

TY - CONF

T1 - Content of alpha-linolenic acid in human atrial tissue correlates with plasma levels of alpha-linolenic acid

AU - Gu, Jiwei

AU - Eschen, Rikke Bülow

AU - Andreasen, Annette

AU - Schmidt, Erik Berg

AU - Andreasen, Jan Jesper

AU - Lundbye-Christensen, Søren

N1 - Poster nr.. 36

PY - 2016/9/5

Y1 - 2016/9/5

N2 - Background: Marine omega-3 fatty acids have antiarrhythmic effects, but whether the plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) have similar effects is less documented. Some data suggest that intake of ALA may reduce sudden cardiac death (and presumably ventricular arrhythmias) but little is known about a possible effect of ALA on atrial arrhythmias including atrial fibrillation (AF). A possible effect of ALA on AF would probably be caused by incorporation of ALA into atrial tissue.Aim of study: To compare plasma phospholipid levels of ALA to levels in atrial muscle tissueMethods: Atrial tissue was obtained from 50 patients during cardiac surgery (valvular surgery and/or coronary artery bypass grafting) and plasma was sampled prior to skin incision. Fatty acid composition was determined in both atrial tissue and plasma phospholipids (49 samples available) by gas chromatography and ALA levels were compared by the Pearson correlation coefficient.Results: There was a statistical significant correlation (r=0.54, 95% confidence interval: 0.30-0.71) between levels of ALA in plasma phospholipids and atrial tissue.Conclusion: The content of ALA in plasma phospholipids is a short term indicator of intake of ALA and this correlated well with the content of ALA in atrial tissue. Atrial tissue is not readily available but this study shows that determination of plasma phospholipids may be useful to further investigate an antiarrhythmic effect of ALA on AF.

AB - Background: Marine omega-3 fatty acids have antiarrhythmic effects, but whether the plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) have similar effects is less documented. Some data suggest that intake of ALA may reduce sudden cardiac death (and presumably ventricular arrhythmias) but little is known about a possible effect of ALA on atrial arrhythmias including atrial fibrillation (AF). A possible effect of ALA on AF would probably be caused by incorporation of ALA into atrial tissue.Aim of study: To compare plasma phospholipid levels of ALA to levels in atrial muscle tissueMethods: Atrial tissue was obtained from 50 patients during cardiac surgery (valvular surgery and/or coronary artery bypass grafting) and plasma was sampled prior to skin incision. Fatty acid composition was determined in both atrial tissue and plasma phospholipids (49 samples available) by gas chromatography and ALA levels were compared by the Pearson correlation coefficient.Results: There was a statistical significant correlation (r=0.54, 95% confidence interval: 0.30-0.71) between levels of ALA in plasma phospholipids and atrial tissue.Conclusion: The content of ALA in plasma phospholipids is a short term indicator of intake of ALA and this correlated well with the content of ALA in atrial tissue. Atrial tissue is not readily available but this study shows that determination of plasma phospholipids may be useful to further investigate an antiarrhythmic effect of ALA on AF.

M3 - Poster

ER -

Gu J, Eschen RB, Andreasen A, Schmidt EB, Andreasen JJ, Lundbye-Christensen S. Content of alpha-linolenic acid in human atrial tissue correlates with plasma levels of alpha-linolenic acid. 2016. Poster præsenteret på 12th Congress of the International Society for the Study of Fatty Acids and Lipids, Cape Town, Sydafrika.