COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure

Loris Pironi; Denise Jezerski; Jacek Sobocki; Simon Lal; Tim Vanuytsel; Miriam Theilla; Anna S. Sasdelli; Cecile Chambrier; Konrad Matysiak; Umberto Aimasso; Henrik H. Rasmussen; Amelia Jukes; Marek Kunecki; David Seguy; Stéphane M. Schneider; Joanne Daniels; Florian Poullenot; Manpreet S. Mundi; Przemysław Matras; Marcin Folwarski; Adriana Crivelli; Nicola Wyer; Lars Ellegard; Lidia Santarpia; Marianna Arvanitakis; Corrado Spaggiari; Georg Lamprecht; Francesco W. Guglielmi; Antonella Lezo; Sabrina Layec; Esther Ramos Boluda; Anat Guz-Mark; Paolo Gandullia; Cristina Cuerda; Emma Osland; Maria I. Spagnuolo; Zeljko Krznaric; Luisa Masconale; Brooke Chapman; María Maíz-Jiménez; Paolo Orlandoni; Mariana Hollanda Martins da Rocha; M. Nuria Virgili-Casas; Maryana Doitchinova-Simeonova; Laszlo Czako; Andrè Van Gossum; Lorenzo D'Antiga; Looi C. Ee; Daruneewan Warodomwichit; Marina Taus; Sanja Kolaček; Ronan Thibault; Giovanna Verlato; Aurora E. Serralde-Zúñiga; José I. Botella-Carretero; Pilar Serrano Aguayo; Gabriel Olveira; Sirinuch Chomtho; Veeradej Pisprasert; Georgijs Moisejevs; Ana Zugasti Murillo; Ma Estrella Petrina Jáuregui; Marta Bueno Díez; Mohammad Shukri Jahit; Narumon Densupsoontorn; Ali Tamer; Giorgia Brillanti; Francisca Joly

doi:10.1016/j.clnesp.2023.03.008

COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure

Loris Pironi^*, Denise Jezerski, Jacek Sobocki, Simon Lal, Tim Vanuytsel, Miriam Theilla, Anna S. Sasdelli, Cecile Chambrier, Konrad Matysiak, Umberto Aimasso, Henrik H. Rasmussen, Amelia Jukes, Marek Kunecki, David Seguy, Stéphane M. Schneider, Joanne Daniels, Florian Poullenot, Manpreet S. Mundi, Przemysław Matras, Marcin FolwarskiAdriana Crivelli, Nicola Wyer, Lars Ellegard, Lidia Santarpia, Marianna Arvanitakis, Corrado Spaggiari, Georg Lamprecht, Francesco W. Guglielmi, Antonella Lezo, Sabrina Layec, Esther Ramos Boluda, Anat Guz-Mark, Paolo Gandullia, Cristina Cuerda, Emma Osland, Maria I. Spagnuolo, Zeljko Krznaric, Luisa Masconale, Brooke Chapman, María Maíz-Jiménez, Paolo Orlandoni, Mariana Hollanda Martins da Rocha, M. Nuria Virgili-Casas, Maryana Doitchinova-Simeonova, Laszlo Czako, Andrè Van Gossum, Lorenzo D'Antiga, Looi C. Ee, Daruneewan Warodomwichit, Marina Taus, Sanja Kolaček, Ronan Thibault, Giovanna Verlato, Aurora E. Serralde-Zúñiga, José I. Botella-Carretero, Pilar Serrano Aguayo, Gabriel Olveira, Sirinuch Chomtho, Veeradej Pisprasert, Georgijs Moisejevs, Ana Zugasti Murillo, Ma Estrella Petrina Jáuregui, Marta Bueno Díez, Mohammad Shukri Jahit, Narumon Densupsoontorn, Ali Tamer, Giorgia Brillanti, Francisca Joly

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Abstract

Background and aims
To investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN).

Methods
Period of observation: March 1st, 2020 March 1st, 2021. Inclusion criteria: patients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up.

Results
Sixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths.

Conclusions
In patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.

Originalsprog	Engelsk
Tidsskrift	Clinical Nutrition ESPEN
Vol/bind	55
Sider (fra-til)	212-220
Antal sider	9
ISSN	2405-4577
DOI	https://doi.org/10.1016/j.clnesp.2023.03.008
Status	Udgivet - jun. 2023

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Citationsformater

Pironi, L., Jezerski, D., Sobocki, J., Lal, S., Vanuytsel, T., Theilla, M., Sasdelli, A. S., Chambrier, C., Matysiak, K., Aimasso, U., Rasmussen, H. H., Jukes, A., Kunecki, M., Seguy, D., Schneider, S. M., Daniels, J., Poullenot, F., Mundi, M. S., Matras, P., ... Joly, F. (2023). COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure. Clinical Nutrition ESPEN, 55, 212-220. Advance online publication. https://doi.org/10.1016/j.clnesp.2023.03.008

@article{3878d2ecca6c4f3bb9ea820c22266388,

title = "COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure",

abstract = "Background and aimsTo investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN).MethodsPeriod of observation: March 1st, 2020 March 1st, 2021. Inclusion criteria: patients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up.ResultsSixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths.ConclusionsIn patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.",

keywords = "COVID-19, Epidemiology, Home parenteral nutrition, Intestinal failure, Pandemic, SARS-CoV-2",

author = "Loris Pironi and Denise Jezerski and Jacek Sobocki and Simon Lal and Tim Vanuytsel and Miriam Theilla and Sasdelli, {Anna S.} and Cecile Chambrier and Konrad Matysiak and Umberto Aimasso and Rasmussen, {Henrik H.} and Amelia Jukes and Marek Kunecki and David Seguy and Schneider, {St{\'e}phane M.} and Joanne Daniels and Florian Poullenot and Mundi, {Manpreet S.} and Przemys{\l}aw Matras and Marcin Folwarski and Adriana Crivelli and Nicola Wyer and Lars Ellegard and Lidia Santarpia and Marianna Arvanitakis and Corrado Spaggiari and Georg Lamprecht and Guglielmi, {Francesco W.} and Antonella Lezo and Sabrina Layec and Boluda, {Esther Ramos} and Anat Guz-Mark and Paolo Gandullia and Cristina Cuerda and Emma Osland and Spagnuolo, {Maria I.} and Zeljko Krznaric and Luisa Masconale and Brooke Chapman and Mar{\'i}a Ma{\'i}z-Jim{\'e}nez and Paolo Orlandoni and {Martins da Rocha}, {Mariana Hollanda} and Virgili-Casas, {M. Nuria} and Maryana Doitchinova-Simeonova and Laszlo Czako and {Van Gossum}, Andr{\`e} and Lorenzo D'Antiga and Ee, {Looi C.} and Daruneewan Warodomwichit and Marina Taus and Sanja Kola{\v c}ek and Ronan Thibault and Giovanna Verlato and Serralde-Z{\'u}{\~n}iga, {Aurora E.} and Botella-Carretero, {Jos{\'e} I.} and Aguayo, {Pilar Serrano} and Gabriel Olveira and Sirinuch Chomtho and Veeradej Pisprasert and Georgijs Moisejevs and Murillo, {Ana Zugasti} and J{\'a}uregui, {Ma Estrella Petrina} and D{\'i}ez, {Marta Bueno} and Jahit, {Mohammad Shukri} and Narumon Densupsoontorn and Ali Tamer and Giorgia Brillanti and Francisca Joly",

year = "2023",

month = jun,

doi = "10.1016/j.clnesp.2023.03.008",

language = "English",

volume = "55",

pages = "212--220",

journal = "Clinical Nutrition ESPEN",

issn = "2405-4577",

publisher = "Elsevier",

}

Pironi, L, Jezerski, D, Sobocki, J, Lal, S, Vanuytsel, T, Theilla, M, Sasdelli, AS, Chambrier, C, Matysiak, K, Aimasso, U, Rasmussen, HH, Jukes, A, Kunecki, M, Seguy, D, Schneider, SM, Daniels, J, Poullenot, F, Mundi, MS, Matras, P, Folwarski, M, Crivelli, A, Wyer, N, Ellegard, L, Santarpia, L, Arvanitakis, M, Spaggiari, C, Lamprecht, G, Guglielmi, FW, Lezo, A, Layec, S, Boluda, ER, Guz-Mark, A, Gandullia, P, Cuerda, C, Osland, E, Spagnuolo, MI, Krznaric, Z, Masconale, L, Chapman, B, Maíz-Jiménez, M, Orlandoni, P, Martins da Rocha, MH, Virgili-Casas, MN, Doitchinova-Simeonova, M, Czako, L, Van Gossum, A, D'Antiga, L, Ee, LC, Warodomwichit, D, Taus, M, Kolaček, S, Thibault, R, Verlato, G, Serralde-Zúñiga, AE, Botella-Carretero, JI, Aguayo, PS, Olveira, G, Chomtho, S, Pisprasert, V, Moisejevs, G, Murillo, AZ, Jáuregui, MEP, Díez, MB, Jahit, MS, Densupsoontorn, N, Tamer, A, Brillanti, G & Joly, F 2023, 'COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure', Clinical Nutrition ESPEN, bind 55, s. 212-220. https://doi.org/10.1016/j.clnesp.2023.03.008

TY - JOUR

T1 - COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure

AU - Pironi, Loris

AU - Jezerski, Denise

AU - Sobocki, Jacek

AU - Lal, Simon

AU - Vanuytsel, Tim

AU - Theilla, Miriam

AU - Sasdelli, Anna S.

AU - Chambrier, Cecile

AU - Matysiak, Konrad

AU - Aimasso, Umberto

AU - Rasmussen, Henrik H.

AU - Jukes, Amelia

AU - Kunecki, Marek

AU - Seguy, David

AU - Schneider, Stéphane M.

AU - Daniels, Joanne

AU - Poullenot, Florian

AU - Mundi, Manpreet S.

AU - Matras, Przemysław

AU - Folwarski, Marcin

AU - Crivelli, Adriana

AU - Wyer, Nicola

AU - Ellegard, Lars

AU - Santarpia, Lidia

AU - Arvanitakis, Marianna

AU - Spaggiari, Corrado

AU - Lamprecht, Georg

AU - Guglielmi, Francesco W.

AU - Lezo, Antonella

AU - Layec, Sabrina

AU - Boluda, Esther Ramos

AU - Guz-Mark, Anat

AU - Gandullia, Paolo

AU - Cuerda, Cristina

AU - Osland, Emma

AU - Spagnuolo, Maria I.

AU - Krznaric, Zeljko

AU - Masconale, Luisa

AU - Chapman, Brooke

AU - Maíz-Jiménez, María

AU - Orlandoni, Paolo

AU - Martins da Rocha, Mariana Hollanda

AU - Virgili-Casas, M. Nuria

AU - Doitchinova-Simeonova, Maryana

AU - Czako, Laszlo

AU - Van Gossum, Andrè

AU - D'Antiga, Lorenzo

AU - Ee, Looi C.

AU - Warodomwichit, Daruneewan

AU - Taus, Marina

AU - Kolaček, Sanja

AU - Thibault, Ronan

AU - Verlato, Giovanna

AU - Serralde-Zúñiga, Aurora E.

AU - Botella-Carretero, José I.

AU - Aguayo, Pilar Serrano

AU - Olveira, Gabriel

AU - Chomtho, Sirinuch

AU - Pisprasert, Veeradej

AU - Moisejevs, Georgijs

AU - Murillo, Ana Zugasti

AU - Jáuregui, Ma Estrella Petrina

AU - Díez, Marta Bueno

AU - Jahit, Mohammad Shukri

AU - Densupsoontorn, Narumon

AU - Tamer, Ali

AU - Brillanti, Giorgia

AU - Joly, Francisca

PY - 2023/6

Y1 - 2023/6

N2 - Background and aimsTo investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN).MethodsPeriod of observation: March 1st, 2020 March 1st, 2021. Inclusion criteria: patients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up.ResultsSixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths.ConclusionsIn patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.

AB - Background and aimsTo investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN).MethodsPeriod of observation: March 1st, 2020 March 1st, 2021. Inclusion criteria: patients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up.ResultsSixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths.ConclusionsIn patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.

KW - COVID-19

KW - Epidemiology

KW - Home parenteral nutrition

KW - Intestinal failure

KW - Pandemic

KW - SARS-CoV-2

U2 - 10.1016/j.clnesp.2023.03.008

DO - 10.1016/j.clnesp.2023.03.008

M3 - Journal article

C2 - 37202049

AN - SCOPUS:85151783368

SN - 2405-4577

VL - 55

SP - 212

EP - 220

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

ER -