TY - JOUR
T1 - Decoding the complexity of circular RNAs in cardiovascular disease
AU - Rai, Amit Kumar
AU - Lee, Brooke
AU - Hebbard, Carleigh
AU - Uchida, Shizuka
AU - Garikipati, Venkata Naga Srikanth
PY - 2021/9
Y1 - 2021/9
N2 - Circular RNAs (circRNAs) are a new class of covalently circularized noncoding RNAs widely expressed in the human heart. Emerging evidence suggests they have a regulatory role in a variety of cardiovascular diseases (CVDs). This review's current focus includes our understanding of circRNA classification, biogenesis, function, stability, degradation mechanisms, and their roles in various cardiovascular disease conditions. Our knowledge of circRNA, the relatively recent member of the noncoding RNA family, is still in its infancy; however, recent literature proposes circRNAs may be promising targets for the understanding and treatment of CVD.
AB - Circular RNAs (circRNAs) are a new class of covalently circularized noncoding RNAs widely expressed in the human heart. Emerging evidence suggests they have a regulatory role in a variety of cardiovascular diseases (CVDs). This review's current focus includes our understanding of circRNA classification, biogenesis, function, stability, degradation mechanisms, and their roles in various cardiovascular disease conditions. Our knowledge of circRNA, the relatively recent member of the noncoding RNA family, is still in its infancy; however, recent literature proposes circRNAs may be promising targets for the understanding and treatment of CVD.
KW - Cardiovascular Disease
KW - Circular RNA
KW - RNA binding proteins and micro RNA
UR - http://www.scopus.com/inward/record.url?scp=85110654070&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2021.105766
DO - 10.1016/j.phrs.2021.105766
M3 - Review article
SN - 1043-6618
VL - 171
JO - Pharmacological Research
JF - Pharmacological Research
M1 - 105766
ER -