TY - JOUR
T1 - Delta-cyclodextrin as novel chiral probe for enantiomeric separation by electromigration methods
AU - Wistuba, Dorothee
AU - Bogdanski, Anja
AU - Larsen, Kim Lambertsen
AU - Schurig, Volker
PY - 2006
Y1 - 2006
N2 - Native d-CD has been employed as chiral selector in CE and MEKC. To investigate the potential of the enantiodiscriminating properties of d-CD, negatively charged 5-dimethylamino-1-naphthalene-sulfonyl (dansyl)-, 2,4-dinitrophenyl (DNP)- and FMOC-derivatives of several amino acids, 1,1’-binaphthyl-2,2’-diylhydrogenphosphate, flavanones and three positively charged drugs have been selected as testing samples. Enantioresolution factors up to 4.82 have been observed. The results were compared with those achieved by the conventional running buffer additives a-, b- and g-CDs. For several examples a steady increase of enantioresolution with increasing degree of oligomerization has been detected.
AB - Native d-CD has been employed as chiral selector in CE and MEKC. To investigate the potential of the enantiodiscriminating properties of d-CD, negatively charged 5-dimethylamino-1-naphthalene-sulfonyl (dansyl)-, 2,4-dinitrophenyl (DNP)- and FMOC-derivatives of several amino acids, 1,1’-binaphthyl-2,2’-diylhydrogenphosphate, flavanones and three positively charged drugs have been selected as testing samples. Enantioresolution factors up to 4.82 have been observed. The results were compared with those achieved by the conventional running buffer additives a-, b- and g-CDs. For several examples a steady increase of enantioresolution with increasing degree of oligomerization has been detected.
U2 - 10.1002/elps.200600284
DO - 10.1002/elps.200600284
M3 - Journal article
SN - 0173-0835
VL - 27
SP - 4359
EP - 4363
JO - Electrophoresis
JF - Electrophoresis
IS - 21
ER -