TY - JOUR
T1 - Diabetes and osteoporosis - Treating two entities
T2 - A challenge or cause for concern?
AU - Rasmussen, Nicklas H.
AU - Vestergaard, Peter
N1 - Copyright © 2022. Published by Elsevier Ltd.
PY - 2022/9
Y1 - 2022/9
N2 - People with T1D and T2D have an increased risk of fractures than the general population, posing several significant pathophysiologic, diagnostic, and therapeutic challenges. The pathophysiology is still not fully elucidated, but it is considered a combination of increased skeletal fragility and falls. Diagnostics issues exist, as regular and even newer scan methods underestimate the true incidence of osteoporosis and thus the fracture risk. Therefore, co-managing diabetes and osteoporosis by using top-line strategies is essential to preserve bone health and minimize the risk of falls. The therapeutic focus should start with lifestyle implementation and physical exercise interventions to reduce diabetic complications, strengthen bones, and improve postural control strategies. In addition, osteoporosis should be treated according to current guidelines by including bisphosphonates and antidiabetic drugs that support bone health. Finally, potentially modifiable risk factors for falls should be managed.
AB - People with T1D and T2D have an increased risk of fractures than the general population, posing several significant pathophysiologic, diagnostic, and therapeutic challenges. The pathophysiology is still not fully elucidated, but it is considered a combination of increased skeletal fragility and falls. Diagnostics issues exist, as regular and even newer scan methods underestimate the true incidence of osteoporosis and thus the fracture risk. Therefore, co-managing diabetes and osteoporosis by using top-line strategies is essential to preserve bone health and minimize the risk of falls. The therapeutic focus should start with lifestyle implementation and physical exercise interventions to reduce diabetic complications, strengthen bones, and improve postural control strategies. In addition, osteoporosis should be treated according to current guidelines by including bisphosphonates and antidiabetic drugs that support bone health. Finally, potentially modifiable risk factors for falls should be managed.
KW - Fall
KW - Fractures
KW - Osteoporosis
KW - Skeletal fragility
KW - Type 1 diabetes
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85139246269&partnerID=8YFLogxK
U2 - 10.1016/j.berh.2022.101779
DO - 10.1016/j.berh.2022.101779
M3 - Review article
C2 - 36154803
SN - 1521-6942
VL - 36
JO - Best Practice & Research: Clinical Rheumatology
JF - Best Practice & Research: Clinical Rheumatology
IS - 3
M1 - 101779
ER -